2009
DOI: 10.1016/j.ijbiomac.2009.04.004
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Inhibition of ATPase activity of Escherichia coli ATP synthase by polyphenols

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Cited by 111 publications
(144 citation statements)
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“…Consequently, MccPDI activity correlates with the presence of a functional ATP synthase complex. To determine if a functional ATP synthase is required for susceptibility, we conducted competition experiments in the presence of a previously described ATP synthase inhibitor, the polyphenol resveratrol (8). Inhibition of ATP synthase activity resulted in reduced susceptibility to MccPDI (see Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Consequently, MccPDI activity correlates with the presence of a functional ATP synthase complex. To determine if a functional ATP synthase is required for susceptibility, we conducted competition experiments in the presence of a previously described ATP synthase inhibitor, the polyphenol resveratrol (8). Inhibition of ATP synthase activity resulted in reduced susceptibility to MccPDI (see Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Monocultures of each competing strain also were prepared as controls after inoculation into fresh M9 medium at the same dilution. The ATP synthase inhibitor resveratrol (Sigma-Alrich) was added at a final concentration of 25 g ml Ϫ1 to determine if a functional ATP synthase complex is required for susceptibility to MccPDI (8).…”
Section: Methodsmentioning
confidence: 99%
“…These microdomains sequester the polyphenol, as described recently for autocrine motility factor (AMF)/phosphoglucose isomerase (PGI)-paclitaxel (46), and therefore function as a platform that finely tunes up the tumor cell response to this agent, either directly by inducing cell-cycle arrest or cell death (47) or indirectly by sensitizing the cells to chemotherapeutic agents (11,15). This sensitization could involve the inhibition of the H þ -ATP synthase by resveratrol (48). Similarly to the proton pump inhibitor omeprazole (49), resveratrol could affect the lysosomal function and reduce cell environment acidity, thereby facilitating the drug activity (50).…”
Section: Discussionmentioning
confidence: 98%
“…1A), are known inhibitors of F 1 -ATPase, except that Bacillus PS3 F 1 is insensitive (21,25). We determined their effects on the bulk phase steady-state ATPase of E. coli wildtype F 1 as well as the modified complex that was engineered for direct observation of rotation behavior.…”
Section: Effects Of Piceatannol On Bulk Phasementioning
confidence: 99%