Inhibition of Atherosclerosis by Angiotensin II Type 1 Receptor Antagonists

Peters, Stefan

doi:10.1007/s40256-013-0017-4

Cited by 7 publications

(9 citation statements)

References 30 publications

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“…responses and oxidative stress of various cell types such as endothelium, VSMCs, and macrophages, within atherosclerotic plaques (27,28). AngII upregulates the expression of various pro-inflammatory mediators in VSMCs including TNF-α, MCP-1, IL-6 and nitric oxide synthase (29).…”

Section: Discussionmentioning

confidence: 99%

Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-γ activity and reducing oxidative stress

Yang

et al. 2017

International Journal of Molecular Medicine

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Angiotensin II (AngII)-induced production of inflammatory factors and proliferation in vascular smooth muscle cells (VSMCs) play an important role in the progression of atherosclerotic plaques. Growing evidence has demonstrated that activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) effectively attenuates AngII-induced inflammation and intercellular reactive oxygen species (iROS) production. Curcumin (Cur) inhibits inflammatory responses by enhancing PPAR-γ activity and reducing oxidative stress in various tissues. The aim of the present study was to ascertain whether Cur inhibits AngII-induced inflammation and proliferation, and its underlying molecular mechanism, in VSMCs. Enzyme-linked immunosorbent assay (ELISA) and real-time PCR were used to measure the protein and mRNA expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Nitric oxide (NO) production was measured by Griess reaction. Western blot analysis and a DNA-binding assay were used to measure PPAR-γ activity. iROS production was measured using the DCFH-DA method. In rat VSMCs, Cur attenuated AngII‑induced expression of IL-6 and TNF-α mRNA and protein in a concentration-dependent manner, inhibited NO production by suppressing inducible NO synthase (iNOS) activity, and suppressed proliferation of VSMCs. This was accompanied by increased PPAR-γ expression and activation in Cur-pretreated VSMCs. GW9662, a PPAR-γ antagonist, reversed the anti-inflammatory effect of Cur. Moreover, Cur attenuated AngII-induced oxidative stress by downregulating the expression of p47phox, which is a key subunit of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. In conclusion, Cur inhibited the expression of IL-6 and TNF-α, decreased the production of NO, and suppressed the proliferation of VSMCs, by elevating PPAR-γ activity and suppressing oxidative stress, leading to attenuated AngII-induced inflammatory responses in VSMCs.

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Section: Discussionmentioning

confidence: 99%

Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-γ activity and reducing oxidative stress

Yang

et al. 2017

International Journal of Molecular Medicine

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“…Neointima was composed of various characteristic lesions, such as fibrous tissue, proteoglycan-rich tissue, approved by pathologic examination of restenosis in bare-metal stent (BMS) and in DES in tissue samples obtained by atherectomy [ 20 ]. In the other hand, ARBs inhibit atherosclerosis as reduced plaque burden in atherosclerotic vessels and reduced incidence of in-stent restenosis [ 21 ]. In this concept of anti-inflammatory and anti-proliferative effect of ARBs toward atherosclerosis and neointimal growth, our present study assessed difference of neointimal characterization in use of long term ARBs by OCT.…”

Section: Discussionmentioning

confidence: 99%

“…Available data suggest that the beneficial effects of ARBs on atherosclerosis cannot be considered a class effect. Losartan and candesartan have not shown any effect on atherosclerosis or on in-stent restenosis, but valsartan, olmesartan and telmisartan appear to have a significant beneficial effect [ 21 ]. Also, various types of DES were used, from first generation (SES) to second generation (EES, BES, ZES), limiting this study that second-generation DES lead to a lower percentage of uncovered and malapposed struts, as well as a lower incidence of intra-stent thrombi, compared with first-generation DES [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of angiotensin receptor blockers on neointimal characteristics in angina patients requiring stent implantation: optical coherence tomography analysis

Cho

Hong

Lim

2017

BMC Cardiovasc Disord

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BackgroundAngiotensin receptor blockers (ARBs) are known for its anti-inflammatory and anti-proliferative effects. The aim of the study was to evaluate long-term effects of ARBs on morphologic characteristics of stent restenosis in patients with coronary artery disease requiring stent implantation by optical coherence tomography (OCT).MethodsPatients with coronary artery disease having history of drug-eluting stent implantation (n = 407) were analyzed on the basis of ARB therapy as the ARB group (n = 162) and the non-ARB group (n = 245). Neointimal characterizations were performed at lesions with diameter stenosis >30% with OCT in each group. Major adverse cardiovascular events (MACEs), lumen area, stent area, neointimal area, neointimal thickness, nonapposed struts, uncovered struts, and intraluminal mass between two groups were also observed.ResultsMore patients in the ARB group revealed homogeneous and layered neointimal pattern (44.9% vs. 35.6%, P < 0.001, and 16.8% vs. 10.6%, P < 0.001, respectively), and whereas patients in the non-ARB group revealed heterogeneous neointimal pattern (1.1% vs. 7.6%, P < 0.001). Mean neointimal area (1.09 ± 1.00 mm2 vs. 1.38 ± 1.24 mm2) and mean neointimal thickness (140.6 ± 112.0 μm vs. 189.6 ± 423.1 μm) with OCT were smaller in the ARB group when compared to the non-ARB group. Percentage of covered stents was significantly higher in the ARB group when compared to the Non-ARB group (97.3% vs. 92.6%, P = 0.015). Other factors such as follow-up % diameter stenosis, late lumen loss, binary restenosis, MACEs, various neointimal characteristics analyzed by image analyzing software did not show significant differences.ConclusionThe use of ARBs after drug-eluting stent implantation demonstrated difference in neointimal characteristics, less amount of neointimal area and fewer number of uncovered stent struts during the follow-up OCT, indicating the anti-proliferative and anti-inflammatory effects of ARBs.

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“…However, the level of NO did not change ( in animal models of atherosclerosis [19]. In atheromatous plaque 157 area where macrophages and foam cells, also, accumulate, high 158 concentrations of tissue ACE will produce large amounts of Ang II.…”

Section: Genementioning

confidence: 97%

“…The incidence of coronary heart disease is 17 usually low, where the population of plasma cholesterol levels are 18 low [1]. 19 Atherosclerosis is considered a chronic and progressive disease 20 that may be induced by the injury of the arterial endothelium, 21 proliferation of vascular smooth muscle cells (VSMC), and 22 accumulation of lipids in vessel walls. It is often associated with 23 hypertension, elevated low-density lipoprotein (LDL) and de-24 creased high-density lipoprotein (HDL) levels, and diabetes 25 mellitus [2,3].…”

Section: Q2mentioning

confidence: 99%

The effect of angiotensin-converting enzyme inhibition on inflammatory and angiogenic factors in hypercholesterolemia

Mahmoudabady

Kazemi

Rezaee

et al. 2015

Pharmacological Reports

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Inhibition of Atherosclerosis by Angiotensin II Type 1 Receptor Antagonists

Cited by 7 publications

References 30 publications

Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-γ activity and reducing oxidative stress

Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-γ activity and reducing oxidative stress

Effects of angiotensin receptor blockers on neointimal characteristics in angina patients requiring stent implantation: optical coherence tomography analysis

The effect of angiotensin-converting enzyme inhibition on inflammatory and angiogenic factors in hypercholesterolemia

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