The effect of angiotensin-converting enzyme inhibition on inflammatory and angiogenic factors in hypercholesterolemia

Mahmoudabady, Maryam; Kazemi, N Mohammadian Khabbaz; Rezaee, Seyed Abdolrahim; Soukhtanloo, Mohammad; Hosseini, Mahmoud

doi:10.1016/j.pharep.2015.01.008

Cited by 13 publications

(9 citation statements)

References 34 publications

(14 reference statements)

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“…RAS has also been linked to the pathophysiology hypercholesterolemiainduced systemic inflammation. Ang II was found to enhance monocytes migration and pro-inflammatory cytokine levels throughout hypercholesterolemia [27]. In addition, Ang II is known to promote and regulate the formation of ROS and NO [28].…”

Section: Discussionmentioning

confidence: 99%

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries

et al. 2020

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Objectives: This study explores the protective role of losartan (LT) against oxidative and inflammatory damages in different physiological systems including heart, liver, and kidney tissue in hypercholesterolemic rats. Methods: After induction of hypercholesterolemia by high cholesterol diet for 6 weeks, LT was administered for 4 weeks. In serum, the levels of lipoproteins, aminotransferases, creatine kinases, urea, apoptosis, and inflammatory markers were measured. In cardiac, hepatic, and renal tissues, lipid peroxidation product and GSH as well as antioxidant enzymatic activities were assayed. Finally, histopathological assessment evaluated the structural damage in cardiac, hepatic, and renal tissues. Results: Serum markers of cardiac, hepatic, and renal toxicities including creatine kinases, aminotransferases, and urea were attenuated by LT in hypercholesterolemic animals. Moreover, LT markedly corrected the elevated levels of lipoproteins, apoptosis, and inflammatory biomarkers. Hypercholesterolemia-induced lipid peroxidation, low GSH levels, and diminished activities of antioxidant enzymes were prominently improved in LT treated animals. Histopathological alterations by hypercholesterolemia in heart, liver, and kidney tissues were ameliorated by LT. Conclusion: This study confirmed the pathological enrollment of renin-angiotensin system in hypercholesterolemia-associated metabolic alterations. LT had a significant cardiac, hepatic, and renal protective role against these impairments through down-regulation of oxidative damage, inflammation and necrosis.

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Section: Discussionmentioning

confidence: 99%

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries

et al. 2020

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“…RAS was also linked to the pathophysiology hypercholesterolemia-induced systemic inflammation. Ang II was found to enhance monocytes migration pro-inflammatory cytokine levels throughout hypercholesterolemia [25]. Hypercholesterolemia is known to promote renal formation of free radicals leading to cellular injury and inflammation [37,38].…”

Section: Resultsmentioning

confidence: 99%

Renin Angiotensin System Blockage by Losartan Neutralize Hypercholesterolemia-Induced Inflammatory and Oxidative Injuries

Alsaad

Alasmari

Abuohashish

et al. 2020

Preprint

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Background: Hypercholesterolemia induces several metabolic diseases via oxidative and pro-inflammatory pathways. Renin angiotensin system (RAS) contributes to the pathogenesis of hypercholesterolemia-associated metabolic changes. Therefore, this study aims to explore the protective role of losartan (LT) against oxidative and inflammatory damages in different physiological systems including heart, liver and kidney tissues in hypercholesterolemic rats. Methods: After induction of hypercholesterolemia by high cholesterol diet for 6 weeks, LT was administered for 4 weeks. In serum samples, the levels of lipoproteins, aminotransferases, creatine kinases, urea, apoptosis and inflammatory markers were measured. In cardiac, hepatic and renal tissues, lipid peroxidation product and glutathione as well as antioxidant enzymatic activities were assayed. Finally, histopathological assessment evaluated the structural damage in in cardiac, hepatic and renal tissues. Results: Serum markers of cardiac, hepatic and renal toxicities including creatine kinases, aminotransferases and urea were attenuated by LT in hypercholesterolemic animals. Moreover, LT markedly corrected the elevated levels of lipoproteins, apoptosis and inflammatory biomarkers. Hypercholesterolemia-induced lipid peroxidation, low glutathione levels and diminished activities of antioxidant enzymes were prominently improved in LT treated animals. Histopathological alterations by hypercholesterolemia in heart, liver and kidney tissues were ameliorated by LT. Conclusion: This study confirmed the pathological enrolment of renin-angiotensin system in hypercholesterolemia-associated metabolic alterations. LT had a significant cardiac, hepatic and renal protective role against these impairments through down-regulation of oxidative damage, inflammation and necrosis.

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“…Angiotensin receptor II can promote monocyte migration and local pro-inflammatory cytokine release. Furthermore, because Ang II promotes and regulates the generation of ROS and NO, inhibiting Ang II receptor type 1 (AT1R) could result in a significant reduction in systemic inflammation and oxidative stress (Mahmoudabady et al 2015). According to de Gracia et al (2000), losartan blocks the activity of systemic Ang II, thereby preventing L-NAME from causing hypertension.…”

Section: Discussionmentioning

confidence: 99%

Repercussions of pathway inhibition response of Panaxginseng fractions ameliorate cardiac dysfunction in hypertensive model rats

Ali

Shalaby

Ragab

et al. 2022

ijhs

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This study examined the preventive and therapeutic benefits of various Panax ginseng fractions against NG-nitro-L-arginine methyl ester (L-NAME)-induced hypertension in rats. Rats injected with L-NAME plus vehicle exhibited persistently elevated SBP, serum concentrations of the cardiac injury biomarkers creatine kinase (CK), CK-MB, and troponin, total cholesterol, triglyceride (TG), low-density lipoprotein (LDL), and interleukin (IL)-6, but lower high-density lipoprotein (HDL) compared to the vehicle control group. Furthermore, L-NAME disrupted the normal histological structure and function of rat cardiac tissue. All ginseng fractions and losartan restored SBP to a normal level, reversed the changes in CK, CK-MB, troponin, total cholesterol, TG, HDL, and LDH, and preserved normal myocardial histology, with the WGF demonstrating the greatest cardioprotective and antihypertensive effects. Compounds within multiple ginseng fractions, but especially the aqueous fraction, possess potent and effective antihypertensive, antilipidemic, anti-inflammatory, and cardioprotective properties.

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The effect of angiotensin-converting enzyme inhibition on inflammatory and angiogenic factors in hypercholesterolemia

Abstract: Captopril, an ACE inhibitor, improves hyperlipidemia and prevents from overexpression of genes for VEGF and VCAM-1, that are implicated in the inflammation and angiogenesis.

Cited by 13 publications

References 34 publications

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries

Renin Angiotensin System Blockage by Losartan Neutralize Hypercholesterolemia-Induced Inflammatory and Oxidative Injuries

Repercussions of pathway inhibition response of Panaxginseng fractions ameliorate cardiac dysfunction in hypertensive model rats

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