Inhibition of Arterial Myogenic Responses by a Mixed Aqueous Extract of Salvia Miltiorrhiza and Panax Notoginseng (PASEL) Showing Antihypertensive Effects

Baek, Eun Bok; Yoo, Hae Young; Park, Su Jung; Chung, Young-Shin; Hong, Eun-Kyung; Kim, Sung Joon

doi:10.4196/kjpp.2009.13.4.287

Cited by 12 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, we also demonstrated that SABP attenuated SBP significantly on SHRs, which is consistent with previously report [24]. Ang II and ET-1 are two of the strongest substantial agents to induce vascular contraction.…”

Section: Discussionsupporting

confidence: 81%

Mixed Aqueous Extract of Salvia Miltiorrhiza Reduces Blood Pressure through Inhibition of Vascular Remodelling and Oxidative Stress in Spontaneously Hypertensive Rats

Zhang

et al. 2016

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Salvia miltiorrhiza (SM) contains four major aqueous active ingredients, which have been isolated, purified and identified as danshensu (DSS), salvianolic acid A (Sal-A), salvianolic acid B (Sal-B) and protocatechuic aldehyde (PAL), totally abbreviated as SABP. Although SM is often used to treat various cardiovascular diseases in traditional Chinese medicine, the efficacy and function of optimal compatibility ratio of SM's active ingredients (SABP) in the prevention and treatment of cardiovascular diseases remain uncertain. This study investigated antihypertensive effect and underlying mechanisms of SABP vs. SM lyophilized powder (SMLP) in spontaneously hypertensive rats (SHR) and to establish the ratio of the optimal compatibility of DSS, Sal-A, Sal-B and PAL in improving cardiovascular functions. Methods: The SHRs were treated with either SABP or SMLP and their systolic blood pressures (SBP) were monitored. The isolated thoracic aorta of SHRs was segregated for immunohistochemistry, Hematoxylin-Eosin stain and mRNA and protein expression of NOX4, TGF-β1, Col-I, ET-1, α-SMA and Smad7. Moreover, the adventitial fibroblasts (AFs) were isolated and cultured from SD rats' aorta and the reactive oxygen species (ROS) production was determined after SABP or SMLP treatment. Results: SABP, but not SMLP, significantly reduced SBP, which were accompanied by the inhibited morphological changes in the thoracic aorta and the reduced mRNA and protein expression of NOX4, TGF-β1, Col-I, ET-1 and α-SMA, but the increased Smad 7 expression in SHRs. Moreover, SABP also resulted in a decreased ROS production in AFs of SD rats. Conclusions: These results indicate that SABP, but not SMLP, treatment potently inhibits hypertension through improvements of vascular remodeling and oxidative stress. The present study provides new evidence that the efficacy and function from optimal compatibility ratio of SM active ingredients is much better than its lyophilized powder, which represents a strategy to develop SM's new beneficial effect in improving cardiovascular functions.

show abstract

Section: Discussionsupporting

confidence: 81%

Mixed Aqueous Extract of Salvia Miltiorrhiza Reduces Blood Pressure through Inhibition of Vascular Remodelling and Oxidative Stress in Spontaneously Hypertensive Rats

Zhang

et al. 2016

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…In addition, the blood pressure lowering activity of P. ginseng is due to promotion of vascular endothelial cell-derived nitric oxide (NO) secretion [32,34]. Furthermore, a mixed aqueous extract of salvia miltiorrhiza and P. notoginseng demonstrated anti-hypertensive effects by inhibition of arterial myogenic responses [35]. The collective observations indicate that ginseng normalizes blood pressure and improves blood circulation.…”

Section: Efficacy Of Adjusting Blood Pressurementioning

confidence: 99%

Cardiovascular Diseases and Panax ginseng: A Review on Molecular Mechanisms and Medical Applications

Kim

2012

Journal of Ginseng Research

210

142

View full text Add to dashboard Cite

“…Pharmacological studies indicated that Danshen improved blood microcirculation, dilated coronary arteries, inhibited platelet aggregation and protected the myocardium against ischemia (Zhou et al, 2005;Baek et al, 2009). Sanqi had effectiveness in antagonizing thrombosis, dilating blood vessels and decreasing the ischemia-induced injury of myocardium (Gao et al, 1992;Ng, 2006).…”

Section: Introductionmentioning

confidence: 96%

Proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury

Yue

Xie

Song

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Inhibition of Arterial Myogenic Responses by a Mixed Aqueous Extract of Salvia Miltiorrhiza and Panax Notoginseng (PASEL) Showing Antihypertensive Effects

Cited by 12 publications

References 19 publications

Mixed Aqueous Extract of Salvia Miltiorrhiza Reduces Blood Pressure through Inhibition of Vascular Remodelling and Oxidative Stress in Spontaneously Hypertensive Rats

Mixed Aqueous Extract of Salvia Miltiorrhiza Reduces Blood Pressure through Inhibition of Vascular Remodelling and Oxidative Stress in Spontaneously Hypertensive Rats

Cardiovascular Diseases and Panax ginseng: A Review on Molecular Mechanisms and Medical Applications

Proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury

Contact Info

Product

Resources

About