Inhibition of antigen-induced histamine release by ouabain

Okazaki, Tadao; Ilea, Viorel S.; Okazaki, Atsuyuki; Wicher, Konrad; Reisman, Robert E.; Arbesman, Carl E.

doi:10.1016/0091-6749(76)90061-0

Cited by 18 publications

(9 citation statements)

References 20 publications

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“…This report deals with attempts to use an ionophore and 48/80, both of which cause histamine release by increasing mast cell calcium levels, as pharmacological tools to define the role of the membrane surface active agents, chlorpromazine and lidocaine in the inhibition of histamine release and 45Ca++ flux. It differs from previous reports [12,13], because it expands the profile of L and C and shows a dose response for inhibition curve in both L and C which shows that 45Ca flux and histamine release are inhibited by similar concentrations of L and C.…”

Section: Introductioncontrasting

confidence: 77%

“…In cellular immunity, effector function of cytotoxic lymphocytes, mitogeninduced lymphocyte aggregation and blast transformation could be inhibited by lidocaine and chlorpromazine [10,11]. In immediate hypersensitivity reactions, lidocaine, tetracaine and chlorpromazine have been shown to inhibit both antigen-antibody and 48/80-induced release of mediator of anaphylaxis [12][13][14]24]. This report deals with attempts to use an ionophore and 48/80, both of which cause histamine release by increasing mast cell calcium levels, as pharmacological tools to define the role of the membrane surface active agents, chlorpromazine and lidocaine in the inhibition of histamine release and 45Ca++ flux.…”

Section: Introductionmentioning

confidence: 98%

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Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine

Johnson

Miller

1979

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We studied the effects of lidocaine (L) and chlorromazine (C), two compounds known to affect the binding of calcium to cell membranes, on histamine release and calcium uptake by purified mast cells upon challenge with the ionophore A23,187 or with compound 48/80. At low concentrations L and C inhibited the Ca++ flux as well as histamine release while higher concentration caused enhancement in this function. Evidence was obtained that L 10(-4) M may displace Ca++ from the cell membranes.

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Section: Introductioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 98%

Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine

Johnson

Miller

1979

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“…During dextran-induced paw edema, the increased vascular permeability is dependent on mast cell degranulation as well as on the action of histamine, serotonin, bradykinin, and PGE 2 on the vascular endothelium, which causes leakage of fluid and proteins into the interstitium. The same process is induced by the synthetic 48/80 compound [33][34][35][36][37][38]. In the present study, the Riparin B promoted the significant reduction of paw edema induced for histamine, serotonin, bradykinin, PGE 2 , and 48/80 compound.…”

Section: Discussionsupporting

confidence: 58%

Riparin B, a Synthetic Compound Analogue of Riparin, Inhibits the Systemic Inflammatory Response and Oxidative Stress in Mice

et al. 2015

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The aim of our study was to evaluate the anti-inflammatory, anti-nociceptive, and anti-oxidant action of Riparin B in vivo. We performed experiments in which we induced paw edema by carrageenan and other mediators, carrageenan-induced peritonitis and the level of myeloperoxidase (MPO) activity, pro-inflammatory cytokines (TNF-α and IL-1β), malondialdehyde (MDA) acid, and glutathione (GSH) from the peritoneal fluid. We also performed behavior tests such as acetic acid-induced writhing, formalin-induced linking, and the hot plate test. Among the doses tested of the Riparin B (1, 3, and 10 mg/kg), the dose of 10 mg/kg showed the strongest effect, and this dose was able to reduce the paw edema induced by carrageenan, dextran, histamine serotonin, bradykinin, 48/80, and PGE2. Similarly, the Riparin B in the same dose reduced cell migration and significantly decreased the nociception induced by formalin and acetic acid and reversed the parameters of the oxidative stress. Thus, we can infer that Riparin B exhibits anti-inflammatory, anti-nociceptive, and anti-oxidant actions in vivo.

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“…A controversy exists regarding the role played by ouabain on mast cell degranulation. Stimulatory and inhibitory effects were reported [43, 44]. Some data have also demonstrated that ouabain had no effect on mast cell degranulation [45].…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

Vasconcelos

Leite

Carneiro

et al. 2011

Mediators of Inflammation

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Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to modulate the immune response, little is known about the effect of this substance on the inflammatory process. The aim of this work was to study the effects triggered by ouabain on inflammation and nociceptive models. Ouabain produced a reduction in the mouse paw edema induced by carrageenan, compound 48/80 and zymosan. This anti-inflammatory potential might be related to the inhibition of prostaglandin E2, bradykinin, and mast-cell degranulation but not to histamine. Ouabain also modulated the inflammation induced by concanavalin A by inhibiting cell migration. Besides that, ouabain presented antinociceptive activity. Taken these data together, this work demonstrated, for the first time, that ouabain presented in vivo analgesic and anti-inflammatory effects.

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Inhibition of antigen-induced histamine release by ouabain

Cited by 18 publications

References 20 publications

Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine

Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine

Riparin B, a Synthetic Compound Analogue of Riparin, Inhibits the Systemic Inflammatory Response and Oxidative Stress in Mice

Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

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