2011
DOI: 10.1155/2011/912925
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Abstract: Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to modulate the immune response, little is known about the effect of this substance on the inflammatory process. The aim of this work was to study the effects triggered by ouabain on inflammation and nociceptive models. Ouabain produced a reduction in the mouse p… Show more

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Cited by 54 publications
(53 citation statements)
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“…However, the mechanisms underlying Bufonis venenumand its effective ingredients-induced analgesia especially in cancer pain remain unclear. It was postulated that Bufonis venenum produced antinociception through inhibition of neuronal adenosine triphosphatase sodiumpotassium pump or Na + -K + ATPase [72], as its effective ingredients bufadienolides are a group of steroid hormones, which, like ouabain, inhibit Na + -K + ATPase [11,17,18,41] leading to antinociception [15,68]. Also, it was recently proposed that cinobufagin exerted antinociception via activation of the α-7 nicotinic acetylcholine receptor (α7-nAChR), since cinobufagin antinociception in the hot-plate, formalin and acetic acid writing tests were reversed by intraperitoneal administration of the specific α7-nAChR antagonist methyllycaconitine and intrathecal injection of the α7-nAChR gene silencer siRNA/α7-nAChR [82].…”
Section: Introductionmentioning
confidence: 99%
“…However, the mechanisms underlying Bufonis venenumand its effective ingredients-induced analgesia especially in cancer pain remain unclear. It was postulated that Bufonis venenum produced antinociception through inhibition of neuronal adenosine triphosphatase sodiumpotassium pump or Na + -K + ATPase [72], as its effective ingredients bufadienolides are a group of steroid hormones, which, like ouabain, inhibit Na + -K + ATPase [11,17,18,41] leading to antinociception [15,68]. Also, it was recently proposed that cinobufagin exerted antinociception via activation of the α-7 nicotinic acetylcholine receptor (α7-nAChR), since cinobufagin antinociception in the hot-plate, formalin and acetic acid writing tests were reversed by intraperitoneal administration of the specific α7-nAChR antagonist methyllycaconitine and intrathecal injection of the α7-nAChR gene silencer siRNA/α7-nAChR [82].…”
Section: Introductionmentioning
confidence: 99%
“…Recent studies have demonstrated that bufalin also exhibits a strong, dose-dependent anti-inflammatory effect on carrageenan-induced paw edema in rats by suppressing the activation of NF-κB and reducing the production of its downstream proinflammatory mediators during acute inflammation [13]. Additionally, the bufalin analogues, ouabain, and digoxin, also possess strong anti-inflammatory effects [41,42]. In this study, dexamethasone was used as a reference drug, and it showed similar activities as that of bufalin.…”
Section: Discussionmentioning
confidence: 99%
“…In the immune system, ouabain modulates the expression of several important receptors in lymphocytes and monocytes (35,36), impairs lymphocyte proliferation induced by mitogens (36) and induces cytokine secretion in PBMC (37,38). In addition, the in vivo administration of ouabain has been shown to reduce the amount of mature B lymphocytes in the spleen and prevent the inflammation induced by several substances in mice (39,40).…”
Section: Discussionmentioning
confidence: 99%