Inhibition of aldose reductase by Aegle marmelos and its protective role in diabetic cataract

Srinivas, V.; Kumar, P. Anil; Naik, Ramavat Ravindar; Sridhar, G. R.; Kumar, Manjesh; Gopal, V.; Raju, T.

doi:10.1016/j.jep.2013.06.025

Cited by 37 publications

(25 citation statements)

References 31 publications

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“…70,74 Oxidative stress is considered one of the early causes in the pathway of cataract development. 3,[5][6][7][8][9] AR inhibitors include plant extracts [9][10][11]49 or synthetic compounds. 75 Some of the synthetic agents are used in the clinic.…”

Section: Discussionmentioning

confidence: 99%

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Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast

Mirsky

Cohen

Eliaz

et al. 2016

Exp Biol Med (Maywood)

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Diabetes leads to many complications; among them is the development of cataract. Hyperglycemia brings to increased polyol concentration in the lens, to glycation of lens proteins, and to elevated level of ROS (Reactive Oxygen Species) causing oxidative stress. The glucose tolerance factor (GTF) was found by several groups to decrease hyperglycemia and oxidative stress both in diabetic animals and humans. The aim of our study was to explore the damages induced by high glucose to the eye lens and to assess the protective effects of GTF both in vivo and in vitro. The in vivo study included control healthy rats, streptozotocin (STZ) diabetic untreated rats, and STZ diabetic rats orally treated with 15 doses of GTF. The diabetic untreated rats developed cataracts, whereas the development of cataract was totally or partially prevented in GTF treated animals. In vitro studies were done on bovine lenses incubated for 14 days. Half of the lenses were incubated in normal glucose conditions, and half in high glucose conditions (450 mg%). To one group of the normal or high glucose condition GTF was added. The optical quality of all the lenses was measured daily by an automated scanning laser system. The control lenses, whether with or without GTF addition, did not show any reduction in their quality. High glucose conditions induced optical damage to the lenses. Addition of GTF to high glucose conditions prevented this damage. High glucose conditions affected the activity of aldose reductase and sodium potassium ATPase in lens epithelial cell. Addition of GTF decreased the destructive changes induced by high glucose conditions. The amount of soluble cortical lens proteins was decreased and structural changes were detected in lenses incubated in high glucose medium. These changes could be prevented when GTF was added to high glucose medium. Our findings demonstrate the anticataractogenic potential of GTF.

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Section: Discussionmentioning

confidence: 99%

“…[6][7][8] Several studies presented the major role of polyol in diabetic cataract development. [9][10][11] All of the above cause a reduction in lens transparency and the development of cataract. Much effort has been invested in development of anticataract medications.…”

Section: Introductionmentioning

confidence: 99%

Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast

Mirsky

Cohen

Eliaz

et al. 2016

Exp Biol Med (Maywood)

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“…The leaf extract was also reported to regenerate pancreatic islets in diabetic rats; although the mechanisms for these activities are not fully understood. 1,[4][5][6] Free radicals are generated in the body due to oxidative stress developed during normal metabolic processes or upon exposure to various environmental or chemical factors which subsequently damage the macromolecules like DNA, proteins and lipids. Oxidative stress is one of the contributing factors of various diseases like cancer and diabetes.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Leaf Extract of Aegle marmelos Correa ex Roxb.

Kumar¹,

Bodla²,

Bansal³

2016

Phcogj

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Introduction: Leaf extracts of Aegle marmelos are reported to have hypoglycemic and anticancer effects. While a lot of information is available about the antioxidant activity of fruit of A. marmelos not much information is available about the antioxidant activity of the leaf of A. marmelos. Objective: The primary objective if this study was to ascertain the antioxidant activity of leaf extract of A. marmelos (AME). Methods: AME was evaluated for total phenolic content (TPC) and total flavonoid content (TFC) by Folin-Ciocalteau reagent method and by aluminium chloride method, respectively. Antioxidant activity of AME was assessed by FRAP assay, DPPH assay, ABTS cation scavenging activity and by reducing power determination. Results: High levels of TPC and TFC were found in AME which showed antioxidant activity comparable to vitamin C. Significant correlation

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“…[27] A. marmelos extract does inhibition of aldose reductase and shows its protective role in diabetic cataract. [28] It also shows in vitro inhibitory effects on intestinal α-glucosidase and pancreatic α-amylase. [29] Its LE also prevents secondary complications in STZ-induced diabetic rats due to the presence of limonene as a potent antiglycating agent.…”

Section: Aegle Marmelosmentioning

confidence: 99%

Untitled

2016

IJGP

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The present review explains the use of natural plant products for therapeutics of diabetes. It is a serious metabolic disorder that imposes multiple effects on human health. Although diabetes is curable, an erratic lifestyle always make panic and causes disease severity if proper medication is not being made available. Several ethnomedicines have been used by local people in form of crude extracts prepared from flowers, fruits, and roots of endemic plant species for cure of diabetes. There is a common usage of herbal parts for preparation of concoctions, syrups, vegetables, juices, green tea, from leaves, and roots for therapeutic purposes. This article explains antidiabetic effects of various plant secondary metabolites such as anthraquinones, flavonoids, secoiridoids, iridoids, flavanones, biophenols, triterpenes, benzoic acid derivatives, isochromans, and phytosterols. Daily meals containing good nutraceuticals such as protein and fiber can replace carbohydrate food that is a main source of glucose. Mainly, herbal foods rich in flavanols and polyphenols show hypoglycemic effects and can be used in the prevention of diabetes-induced vascular dysfunctions. Antidiabetic plant natural products restore insulin level and increase utilization of external glucose. Herbal dietary supplementation having diverse antioxidants, fibers, minerals, and antiglycants show inhibitory activity against α-amylase and α-glycosidase can easily control carbohydrate metabolism in humans. No doubt plant origin natural products can be used as alternative medicine for treatment of diabetes, but they must need proper composition and formulation before being used.

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Inhibition of aldose reductase by Aegle marmelos and its protective role in diabetic cataract

Cited by 37 publications

References 31 publications

Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast

Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast

Antioxidant Activity of Leaf Extract of Aegle marmelos Correa ex Roxb.

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