Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits

Dongare, Vandana; Kulkarni, Chaitanya A.; Kondawar, M. S.; Magdum, C. S.; Haldavnekar, Vivek S.; Arvindekar, Akalpita U.

doi:10.1016/j.foodchem.2011.11.005

Cited by 60 publications

(38 citation statements)

References 23 publications

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“…The efficacy of TA is mediated by improving the glycemic control mechanisms and increasing insulin secretion from remnant pancreatic b-cells. Our study showed that TA improved the biochemical and histopathological changes associated with diabetes and results obtained are in accordance with the existing reports [14]. The persistent supra-physiological level of glucose nonenzymatically reacts with Hb to form increased HbA1c which is a standard biochemical marker for the diagnosis of ambient glycemia during a period of 3-month [34].…”

Section: Discussionsupporting

confidence: 91%

“…The hypoglycemic activity of TA is almost comparable to that of glibenclamide treated group. This correlates well with the previous reports that TA possesses hypoglycemic properties [14].…”

Section: Groupssupporting

confidence: 93%

“…F. vulgare is a well-known medicinal plant traditionally used for its antioxidant, anti-inflammatory, antigenotoxic, antipyretic, and anti-carcinogenic properties [10e13]. Prolonged treatment with the petroleum ether fraction of the F. vulgare extract confirmed the improvement in blood glucose, lipid profile, HbA1c and other parameters in streptozotocin-induced diabetic rats [14]. TA is known for flavoring, alcoholic beverage production and pharmaceutical formulations [15] and its safety certification has been issued by the United States Food and Drug Administration (FDA-US) [16].…”

Section: Introductionmentioning

confidence: 99%

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Trans-anethole, a terpenoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats

et al. 2015

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Section: Discussionsupporting

confidence: 91%

“…The hypoglycemic activity of TA is almost comparable to that of glibenclamide treated group. This correlates well with the previous reports that TA possesses hypoglycemic properties [14].…”

Section: Groupssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Trans-anethole, a terpenoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats

et al. 2015

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“…70,74 Oxidative stress is considered one of the early causes in the pathway of cataract development. 3,[5][6][7][8][9] AR inhibitors include plant extracts [9][10][11]49 or synthetic compounds. 75 Some of the synthetic agents are used in the clinic.…”

Section: Discussionmentioning

confidence: 99%

Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast

Mirsky

Cohen

Eliaz

et al. 2016

Exp Biol Med (Maywood)

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Diabetes leads to many complications; among them is the development of cataract. Hyperglycemia brings to increased polyol concentration in the lens, to glycation of lens proteins, and to elevated level of ROS (Reactive Oxygen Species) causing oxidative stress. The glucose tolerance factor (GTF) was found by several groups to decrease hyperglycemia and oxidative stress both in diabetic animals and humans. The aim of our study was to explore the damages induced by high glucose to the eye lens and to assess the protective effects of GTF both in vivo and in vitro. The in vivo study included control healthy rats, streptozotocin (STZ) diabetic untreated rats, and STZ diabetic rats orally treated with 15 doses of GTF. The diabetic untreated rats developed cataracts, whereas the development of cataract was totally or partially prevented in GTF treated animals. In vitro studies were done on bovine lenses incubated for 14 days. Half of the lenses were incubated in normal glucose conditions, and half in high glucose conditions (450 mg%). To one group of the normal or high glucose condition GTF was added. The optical quality of all the lenses was measured daily by an automated scanning laser system. The control lenses, whether with or without GTF addition, did not show any reduction in their quality. High glucose conditions induced optical damage to the lenses. Addition of GTF to high glucose conditions prevented this damage. High glucose conditions affected the activity of aldose reductase and sodium potassium ATPase in lens epithelial cell. Addition of GTF decreased the destructive changes induced by high glucose conditions. The amount of soluble cortical lens proteins was decreased and structural changes were detected in lenses incubated in high glucose medium. These changes could be prevented when GTF was added to high glucose medium. Our findings demonstrate the anticataractogenic potential of GTF.

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“…No reports on toxicity. (Dongare et al, 2012). The plant is not toxic at therapeutic doses (Shah et al, 1991 Decoctions of this species has antioxidant and acetylcholinester ase inhibitory capacity (Ferreira et al, 2006).…”

Section: The Most Reported Plants Have the Highest Uv Valuesmentioning

confidence: 99%

An ethnomedicinal survey of a Tashelhit-speaking community in the High Atlas, Morocco

Teixidor‐Toneu

Martin²,

Ouhammou

et al. 2016

Journal of Ethnopharmacology

116

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ethnomedicinal survey of a Tashelhitspeaking community in the High Atlas, Morocco, Journal of Ethnopharmacology, http://dx.doi.org/10. 1016/j.jep.2016.05.009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ABSTRACT Ethnopharmacological relevanceTraditional knowledge about medicinal plants from a poorly studied region, the High Atlas in Morocco, is reported here for the first time; this permits consideration of efficacy and safety of current practices whilst highlighting species previously not known to have traditional medicinal use. Aim of the studyOur study aims to document local medicinal plant knowledge among Tashelhit speaking communities through ethnobotanical survey, identifying preferred species and new medicinal plant citations and illuminating the relationship between emic and etic ailment classifications. Materials and methodsEthnobotanical data were collected using standard methods and with prior informed consent obtained before all interactions, data were characterized using descriptive indices and medicinal plants and healing strategies relevant to local livelihoods were identified.Results 151 vernacular names corresponding to 159 botanical species were found to be used to treat 36 folk ailments grouped in 14 biomedical use categories. Thirty-five (22%) are new medicinal plant records in Morocco, and 26 described as used for the first time anywhere. Fidelity levels (FL) revealed low specificity in plant use, particularly for the most commonly reported plants. Most plants are used in mixtures. Plant use is driven by local concepts of disease, including "hot" and "cold" classification and beliefs in supernatural forces. 2 ConclusionLocal medicinal plant knowledge is rich in the High Atlas, where local populations still rely on medicinal plants for healthcare. We found experimental evidence of safe and effective use of medicinal plants in the High Atlas; but we highlight the use of eight poisonous species.

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Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits

Cited by 60 publications

References 23 publications

Trans-anethole, a terpenoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats

Trans-anethole, a terpenoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats

Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast

An ethnomedicinal survey of a Tashelhit-speaking community in the High Atlas, Morocco

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