Inhibition of AGEs formation by natural products

Nagai, Ryoji; Shirakawa, Jun; Ohno, Rei-ichi; Moroishi, Narumi; Nagai, Mime

doi:10.1007/s00726-013-1487-z

Cited by 46 publications

(38 citation statements)

References 31 publications

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“…The assembly process for immunoreaction-related biocathode was first monitored by impedance spectroscopy of the GN/GCE, Ab 1 /GN/GCE and BOD/CNT/mAb 2 /CML/Ab 1 /GN/GC using K 4 Fe(CN) 6 as electrochemical redox probe, as shown in Figure 2A. The GN/ GCE shows the lowest resistance (R et ), indicating the highly conductive GN can form good electronic and ionic conduction pathways between the electrode and electrolyte.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Carbon Nanotube–Bilirubin Oxidase Bioconjugate as a New Biofuel Cell Label for Self-Powered Immunosensor

et al. 2014

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We demonstrated a biofuel cells (BFCs)-based self-powered sensing system for the detection of Nε-(carboxymethyl)lysine (CML), in which the bilirubin oxidase (BOD)-carbon nanotube (CNT) bioconjugate modified with antibody acted as a biocatalyst for enhancing O2 reduction in the biocathode, as well as the transducing enzyme for signaling magnification. With an increase in the concentration of CML, the amount of BOD labels on biocathode surface increases, thus leading to the higher output of the as-prepared BFCs. This novel BFCs-based self-powered sensor showed a wide linear range for analyzing CML from 1 nM to 100 μM with a detection limit of 0.2 nM, which was 50 times more sensitive than that determined from the conventional ELISA. Most importantly, our new self-powered sensing platform can determine the level of CML in serum samples from multiple healthy donors and multiple sclerosis patients, being well in accordance with that from the commercial ELISA analysis.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Carbon Nanotube–Bilirubin Oxidase Bioconjugate as a New Biofuel Cell Label for Self-Powered Immunosensor

et al. 2014

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“…This is evidenced by the higher dAGE values of samples grilled at There are many strategies to reduce the dAGE intake. Some herbs, condiments and spices, have been reported to have intrinsic antiglycation activity [6,18]. For example, pre-treatment of meats with lemon, vinegar or with any acidic marinade before cooking has a significant effect in preventing the excessive increase of dAGE content.…”

Section: Dietary Agesmentioning

confidence: 99%

Advanced Glycation End Products (Ages) in Food: Focusing on Mediterranean Pasta

Abate¹,

Delbarba²,

Marziano³

et al. 2015

J Nutr Food Sci

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Advanced glycation end products, also known as glycotoxins, are a diverse group of highly oxidant compounds with pathogenic significance in aged-chronic disease, including diabetes, cardiovascular disease and neurodegenerative disease. They are produced physiologically in the body when reducing sugar binds to a free amino acid group of macromolecules. Thus conditions such as hyperglycemia and/or oxidative stress can favor AGE product formation, contributing to ageing processes and the exacerbation of pathological states. Beside endogenous AGEs, dietary AGE intake contributes significantly to the body AGE pool. It assumes that if dietary AGE intake gets lower, any chronic disease, such as diabetes and cardiovascular disease can be ameliorated, and even cured. For this reason, recently great attention has been made on the identification and quantification of AGE products in the consumed foods. Here we reviewed some knowledge, found in literature, concerning the formation of AGEs in food, their gastrointestinal absorption, and their toxic effects. In addition original data on AGE content in the Mediterranean pasta was discussed in relation to their production processes and cooking time.

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“…Several other lifestyle habits, including the type of food consumed, levels of exercise, amount of sleep, and degree of stress have been associated with varying levels of AGE load in the body [15,16]. Phytochemical constituents in plant based foods-including flavonoids, some carotenoids, cinnamic acid derivatives, and stilbene derivatives-have also shown promise as AGE controlling agents [17,18]. The mechanisms of action of these natural AGE inhibitors include inhibition of α-amylase, α-glucosidase, aldose reductase, sorbitol dehydrogenase, and NF-κβ activities, as well as inhibition of glucose absorption.…”

Section: Introductionmentioning

confidence: 99%

Iridoids are natural glycation inhibitors

West¹,

Deng²,

Uwaya³

et al. 2016

Glycoconj J

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Glycation of amino acid residues in proteins leads to the eventual formation of advanced glycation end products (AGEs). AGE formation significantly influences human health and the aging process. AGE accumulation rates may be slowed by modifications to lifestyle or by pharmacological strategies. But the use of therapeutic drugs is not an appropriate means of controlling AGEs within the general population. However, phytochemical constituents in plant-based foods exhibit anti-glycation activities and may be more appropriate for general consumption. Among these phytochemicals are iridoids. The anti-AGE potential of iridoids has been demonstrated in vitro and in vivo, while also revealing possible mechanisms of action. Inclusion of iridoid food sources in the diet may be a useful component of strategies intended to mitigate AGE accumulation within the body.

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Inhibition of AGEs formation by natural products

Cited by 46 publications

References 31 publications

Carbon Nanotube–Bilirubin Oxidase Bioconjugate as a New Biofuel Cell Label for Self-Powered Immunosensor

Carbon Nanotube–Bilirubin Oxidase Bioconjugate as a New Biofuel Cell Label for Self-Powered Immunosensor

Advanced Glycation End Products (Ages) in Food: Focusing on Mediterranean Pasta

Iridoids are natural glycation inhibitors

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