Inhibition of 5-Lipoxygenase by Substituted 3,4-Dihydro-2H-1,4-thiazines

Regioselective and stereospecific synthesis of functionalized 3,4-dihydro-2H-1,4-thiazines by catalyst-free [3 + 3] annulation of pyridinium 1,4-zwitterionic thiolates and aziridines

“…1,4-Thiazines (thiomorpholines) and their oxidized derivatives are prevalent in various natural and synthetic pharmaceutical molecules, 1 exhibiting a broad range of biological properties such as antibacterial, 2 anti-inflammatory, 3 antioxidant 4 and 5-lipoxygenase inhibitory properties 5 (Fig. 1).…”