Inhibition of 11β-hydroxysteroid dehydrogenase by bioflavonoids and their interaction with furosemide and gossypol

Guo, Jun; Reidenberg, Marcus M.

doi:10.1016/s0022-2143(98)90022-1

Cited by 18 publications

(4 citation statements)

References 23 publications

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“…According to several workers (Zhang & Wang, 1997;Guo & Reidenberg, 1998;Wang et al, 2002), flavonoids inhibit the action of 11βHSD2. This enzyme, localized to mineralocorticoid target cells in the kidney, colon and parotid glands as well as to the pancreas and placenta (Mercer & Krozowski, 1992;Brown et al, 1993;Albiston et al, 1994) was identified as the enzymatic "gatekeeper" that catalyses the conversion of the active glucocorticoid into the inactive form, thus excluding active glucocorticoids from the non-specific mineralocorticoid receptors which display little inherent specificity for their normal ligand, aldosterone (Krozowski & Funder, 1983;Arriza et al, 1987).…”

Section: Discussionmentioning

confidence: 98%

“…Since glucocorticoids induce the expression of milk proteins such as casein and lactalbumin (Ono & Oka, 1980), the postpartum decrease in 11βHSD2 activity, and hence increased active glucocorticoids, is a prerequisite for the endocrine induction of lactation (Quirk et al, 1990). The report by several workers that flavonoids inhibit the activity of 11βHSD2 (Zhang & Wang, 1997;Guo & Reidenberg, 1998;Wang et al, 2002) suggests that consumption of aqueous extract of HS, reported to be rich in flavonoids (Dafallah & Al-Mustafa, 1996;Appel, 2003;Adigun et al, 2006), during lactation, further increases the concentration of active glucocorticoids. This may explain the increased corticosterone level as observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Mechanism of delayed puberty in rats whose mothers consumedHibiscus sabdariffaduring lactation

Iyare¹,

Adegoke²,

Nwagha³

2010

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Mechanism of delayed puberty in rats whose mothers consumedHibiscus sabdariffaduring lactation

Iyare¹,

Adegoke²,

Nwagha³

2010

Pharmaceutical Biology

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“…In the present study, there was increased maternal plasma glucocorticoid level possibly due to the osmotic and nutrient stresses in the HS dams as a result of the HS-induced increase in plasma Na + concentration (Iyare and Adegoke, 2008). In addition, the flavonoids in the HS extract have been shown to inhibit the activity of 11βOHSD-2 (Wand et al, 2002;Guo and Reidenberg, 1998;Zhang and Wang, 1997;Lee et al, 1996). This greatly reduces the conversion of the active glucocorticoid to the inactive form and thus increases the level of glucocorticoid reaching the foetus.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of the delayed puberty onset in offspring of rats that consumed aqueous extract of hibiscus sabdariffa during pregnancy

Iyare¹,

Adegoke²

2010

Nig. J. Phys Sci

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Summary: Consumption of extracts of Hibiscus sabdariffa (family: malvaceae) during pregnancy has been shown to cause maternal malnutrition which has been linked to various adverse conditions like increased postnatal weight gain, delayed puberty onset and elevated body weight and body mass index at onset of puberty in the female offspring. The present study was designed to investigate the possible mechanism underlying this. Eighteen in-bred pregnant Sprague-Dawley rats were on day 1 of pregnancy, randomly divided into three groups of six animals each. Group A (control) was given tap water to drink. Group B was given 0.6g extract/100ml while Group C was given 1.8g extract/100ml as their drinking solution. All groups received normal rat chow and their drinking solution ad libitum. Fluid and food intake and dam weights were measured daily throughout pregnancy. On gestational day 18, blood sample was withdrawn from each rat for estimation of plasma Na ion and corticosterone levels. On the day of delivery, the solutions of the extracts of Hibiscus sabdariffa were withdrawn and replaced with tap water. After 21 days, the pups were weaned to tap water and food ad libitum. Pups weight and age and body mass index at onset of puberty were measured. The results of the present study showed that the increased postnatal weight gain, delayed puberty onset and elevated body mass index at onset of puberty in the offspring of rats that consumed HS during pregnancy was associated with elevated maternal plasma Na ion and corticosterone levels during pregnancy.

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“…The increase in body weight could be attributed to the following: the developing foetuses of the Hs dams might have mustered adaptive mechanisms to safeguard their growth and development [19,20], and/or the malnutrition in the Hs dams that started early in pregnancy may have prompted placental development that may have favoured elevated nutrient delivery to the growing foetuses [21][22][23], lastly, the flavonoid constituent of Hs might have directly influenced the growth of the foetuses, as flavonoids have demonstrated direct growth promoting effect [24]. Moreover, the flavonoids in the Hs extract could have inhibited the activity of 11β-hydroxysteroid dehydrogenase type 2 (11βHSD-2) [25][26][27]. This greatly reduces the conversion of the active glucocorticoid to the inactive form and thus increases the level of glucocorticoid reaching the foetus.…”

Section: Discussionmentioning

confidence: 99%

Effect of perinatal administration of flavonoid-rich extract from Hibiscus sabdariffa to feed-restricted rats, on offspring postnatal growth and reproductive development

Chukwu¹,

Emelike

Konyefom

et al. 2021

Current Issues in Pharmacy and Medical Sciences

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Developmental programming is a process where stimulus or insult acting during critical periods of growth and development might permanently alter tissue anatomy and physiology so as to produce adverse effects in adult life. Most forms of exposure include maternal nutrient deprivation, nutrient excess, exogenous glucocorticoid excess and endogenous glucocorticoid due to maternal stress. Hibiscus sabdariffa (Hs) are highly rich in phenolic compounds with marked physiological activities, the sweetened aqueous extract of Hs, commonly known as “Zobo’ in Nigeria, is consumed by humans including pregnant and lactating mothers. This study aimed at determining effects of perinatal administration of flavonoid-rich extract from Hs to feed-restricted rats, on offspring postnatal growth and reproductive development. Twenty-five pregnant female rats were used. Rats were randomly placed into five groups of five rats per group (one animal per cage): Group I (Normal control); Group II (feed-restricted control); Group III (5 mg/kg extract + 70% feed-restricted diet); Group IV (10 mg/kg extract + 70% feed-restricted diet); Group V (20 mg/kg extract + 70% feed-restricted diet). Dams were allowed to nurse only 8 pups. Pups were weaned to ad libitum feed and water and were observed daily for puberty onset. Weights, lengths and body mass index (BMI) of pups were measured at delivery, weaning and puberty onset. At onset of puberty in each of the rats, blood samples were collected for determination of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol and testosterone. Reproductive organs were excised and weighed for histology. The extract caused significant increase in postnatal weight, length and BMI of offspring at birth, weaning and puberty onset and significantly delayed puberty onset in both sexes. There was significant increase in absolute and relative weights of testes and ovaries with alterations in histology. This study has shown that maternal consumption of flavonoid-rich extract of Hs during pregnancy and lactation may accelerate offspring postnatal growth with delay in onset of puberty.

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Inhibition of 11β-hydroxysteroid dehydrogenase by bioflavonoids and their interaction with furosemide and gossypol

Cited by 18 publications

References 23 publications

Mechanism of delayed puberty in rats whose mothers consumedHibiscus sabdariffaduring lactation

Mechanism of delayed puberty in rats whose mothers consumedHibiscus sabdariffaduring lactation

Mechanism of the delayed puberty onset in offspring of rats that consumed aqueous extract of hibiscus sabdariffa during pregnancy

Effect of perinatal administration of flavonoid-rich extract from Hibiscus sabdariffa to feed-restricted rats, on offspring postnatal growth and reproductive development

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