Inhibition growth of pomegranate seeds extract against streptococcus sanguis: the cause of recurrent aphthous stomatitis

Setiadhi, Riani; Sufiawati, Irna; Zakiawati, Dewi; Nur’aeny, Nanan; Hidayat, Wahyu; Firman, Dani Rizali

doi:10.15562/jdmfs.v2i1.452

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…e lyophilized powder was diluted in distilled water on the day of treatment. e treated doses used for PgSE were as previously reported [42]. Each rat received 40 mg/kg body weight in a total volume of 1 ml by stomach tube during the experimental period.…”

Section: Preparation Of Pomegranate Extract (Pgse)mentioning

confidence: 99%

Pomegranate Seeds Extract Possesses a Protective Effect against Tramadol-Induced Testicular Toxicity in Experimental Rats

Minisy

Shawki

Omri

et al. 2020

BioMed Research International

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Tramadol is a centrally acting opioid analgesic that is extensively used. The chronic exposure to tramadol induces oxidative stress and toxicity especially for patients consuming it several times a day. Previously, we and others reported that tramadol induces testicular damage in rats. This study was conducted to investigate the possible protective effect of pomegranate seed extract (PgSE) against tramadol-induced testicular damage in adult and adolescent rats. Male rats were orally treated with tramadol or in a combination with PgSE for three weeks. Testes were then dissected and analyzed. Histological and ultrastructural examinations indicated that tramadol induced many structural changes in the testes of adult and adolescent rats including hemorrhage of blood vessels, intercellular spaces, interstitial vacuoles, exfoliation of germ cells in lumen, cell apoptosis, chromatin degeneration of elongated spermatids, and malformation of sperm axonemes. Interestingly, these abnormalities were not observed in tramadol/PgSE cotreated rats. The morphometric analysis revealed that tramadol disrupted collagen metabolism by elevating testicular levels of collagen fibers but that was protected in tramadol/PgSE cotreatment at both ages. In addition, DNA ploidy revealed that S phase of the cell cycle was diminished when adult and adolescent rats were treated with tramadol. However, the S phase had a normal cell population in the cotreated adult rats, but adolescent rats had a lower population than controls. Furthermore, the phytochemistry of PgSE revealed a high content of total polyphenols and total flavonoids within this extract; besides, the DPPH free radical scavenging activity was high. In conclusion, this study indicated that PgSE has a prophylactic effect against tramadol-induced testicular damage in both adult and adolescent ages, although the tramadol toxicity was higher in adolescent age to be completely protected. This prophylactic effect might be due to the high antioxidant compounds within the pomegranate seeds.

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Section: Preparation Of Pomegranate Extract (Pgse)mentioning

confidence: 99%

Pomegranate Seeds Extract Possesses a Protective Effect against Tramadol-Induced Testicular Toxicity in Experimental Rats

Minisy

Shawki

Omri

et al. 2020

BioMed Research International

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“…Pomegranate peel extract has been proven in numerous studies to have antibacterial, antifungal (Foss et al, 2014; Singh et al, 2019), antiprotozoal Dell'Agli et al, 2009; El‐Sherbini & Shoukry, 2012; Amer et al, 2015), anthelminthic, and antioxidant properties (Boonmasawai et al, 2013; Castagna et al, 2022; Dkhil, 2013; Kaiaty et al, 2021; Saptarini & Mustarichie, 2021). Only a few studies have so far been published about the possible health benefits of pomegranate seeds, including their antibacterial (Setiadhi et al, 2017), antioxidants, anti‐inflammatory properties (Basiri, 2015; Fadavi et al, 2006; Lansky & Newman, 2007; Pedriali et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

In vitro studies for antiparasitic activities of Punica granatum extract

Al‐Shaebi,

Al‐Quraishy,

Maodaa

et al. 2023

Microscopy Res & Technique

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Because of the drug resistance, medicinal plants are used more frequently than coccidiostats to treat and control coccidiosis. Punica granatum is a powerful antioxidant with a variety of medicinal uses. This study used an in vitro experiment to investigate how different P. granatum from Yemen (Y) and Egypt (E) sources affected oocyst sporulation and served as an anthelminthic effector. In contrast to PGE and mebendazole, PGY (200 mg/mL) has the shortest time to paralyze and death the earthworm Eisenia fetida in this investigation. In addition, the treated worm groups' cuticle thickness and shrinkage in comparison to the control group were assessed and contrasted. Eimeria papillata is used as a model protozoan parasite in anticoccidial assays. This study shows that P. granatum affects oocysts sporulation in a dose‐dependent manner, with maximal percentages of 100% (PGY) and 48.60% (PGE) at 96 h for P. granatum concentrations of 200 mg/mL. Inhibition (%) was compared to various detergents, as well as positive and negative controls. According to our research, the P. granatum extract had powerful anthelmintic and anticoccidial properties, with the potency changing according to the environmental conditions of each fruit source.Research Highlights Habitat of the plant is useful for production and accumulation of some secondary metabolites in plants which be effective for the therapeutic uses. Different parameters in the environmental ecosystem affecting variation in chemical compositions and biological activity of P. granatum.

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“…8 The phytochemical screening proved that pomegranate seeds extract contains phenolic, flavonoids, alkaloids, saponins and tannins. 11 Alkaloids are an alkaline organic containing nitrogen (N) generally derived from plants as the secondary metabolism, commonly found in the leaves, twigs, seeds, and bark. Alkaloids have strong physiological effects on humans.…”

Section: Introductionmentioning

confidence: 99%

Identification of active component in red pomegranate (punica granatum L.) seeds ethanolic extract

Setiadhi¹,

Sufiawati²,

Hidayat³

2019

J Dentomaxillofac Sci

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Objective: Pomegranate (punica granatum l.) have many benefits for health and used as traditional medicine. The pomegranate seeds are rich in antioxidants, namely flavonoids and tannins as well as alkaloid which is an antibacterial. The Aim of this study was to identify the pure isolate/active component of red pomegranate seeds ethanolic extract. Material and Methods: Two-ways TLC of the purified crystals which were obtained from the hexan fraction of ethanolic extract red pomegranate seeds, were used to make sure there was only 1 active compound of red pomegranate seeds. The isolate was identified using dragendorff, Mg and HCl, NaOH, Bunchard, Liebermen, FeCL 3 and HCl concentrated reagents. active compound of red pomegranate seeds. The isolate was identified using dragendorff, Mg and HCl, NaOH, Bunchard, Lieberme using dragendorff, Mg and HCl, NaOH, Bunchard, Liebermen, FeCL 3 and HCl concentrated reagents. Results: Isolate identification test using dragendorf reagents showed positive result (an orange-coloured). Conclusion: The pure isolate/active component of red pomegranate seeds is alkaloid.

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Inhibition growth of pomegranate seeds extract against streptococcus sanguis: the cause of recurrent aphthous stomatitis

Cited by 6 publications

References 2 publications

Pomegranate Seeds Extract Possesses a Protective Effect against Tramadol-Induced Testicular Toxicity in Experimental Rats

Pomegranate Seeds Extract Possesses a Protective Effect against Tramadol-Induced Testicular Toxicity in Experimental Rats

In vitro studies for antiparasitic activities of Punica granatum extract

Identification of active component in red pomegranate (punica granatum L.) seeds ethanolic extract

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