Inhibition Effect of Gold (III) Theophylline Nano-complex on ALT Enzyme Activity in Human Serumof Iraqi Patients with Liver Disease

Abstract

Introduction: The ultrasonic sonication approach was used to create an Au(III) nano complex with theophylline. Methods: To explore and suggest the structure of the nano complex, UV-Vis spectroscopy, Fourier transform infrared (FT-IR), and carbon hydrogen and nitrogen (CHN) elemental studies were used. The FE-SEM was used to prove the nanoscale of the prepared complex and was to be less than 20 nm. The effect of the gold nano complex (Au (THP)2(Cl)2) on alanine transaminase (ALT) activity in the serum of chronic liver disease patients was investigated. Results: Compared to the control group, the patients with chronic liver disease with and without nano complex had a significant rise in serum levels of ALT activity (P < 0.001). Furthermore, in individuals with chronic liver disease who received nano complex, the blood levels of ALT activity were significantly lower than those who did not receive nano complex. The reason is that the Au nano complex aggressively interacts with carboxylic groups of important enzymes and inactivates them; further, the Au nano complex had an inhibitory effect on serum ALT activity.