Inhibition by gomisin C (a lignan from <i>Schizandra chinensis</i>) of the respiratory burst of rat neutrophils

Wang, Jih P.; Raung, Shue L; Hsu, Mei F.; Chen, Chien C.

doi:10.1111/j.1476-5381.1994.tb17084.x

Cited by 50 publications

(41 citation statements)

References 52 publications

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“…241 Gomicin C, a lignin extract from Schizandra chinensis, decreases cytosolic calcium levels in intracellular stores and exhibits weak inhibitory action against NOX2. 242 Compounds, such as 6-aminonicotinamide, dearth the availability of electron donors, such as NADPH, and inhibit the pentose phosphate pathway, which precludes NOX activation. 243,244 Furthermore, NOX activation is also regulated through angiotensin II, platelet-derived growth factor and TGF, all of which are blocked through valsartan.…”

Section: Nox Inhibitorsmentioning

confidence: 99%

“…This molecule is potentially useful in pathological conditions because it completely inhibits superoxide production at a low concentration, even after the enzyme is activated. 242,249 Another plant-derived compound, Plumbagin, inhibits NOX4 oxidase activity and exerts anticarcinogenic and anti-atherosclerosis effects in animals. 250 The decreased activity of NOX4 has been demonstrated in plumbagin-treated human embryonic kidney 293 (HEK293) and brain tumor LN229 cells.…”

Section: Nox Inhibitorsmentioning

confidence: 99%

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NADPH oxidases: an overview from structure to innate immunity-associated pathologies

et al. 2014

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Section: Nox Inhibitorsmentioning

confidence: 99%

Section: Nox Inhibitorsmentioning

confidence: 99%

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

et al. 2014

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“…zi, 'five flavor berry') (family Magnoliaceae) is a medicinal plant whose fruits are commonly used in Asian traditional medicine for their sedative/hypnotic, hepatoprotective 1 and antioxidant 2 properties. In 1979, lignan phytoestrogens, known as 'Gomisins' , were first isolated as the active agents of SC.…”

mentioning

confidence: 99%

Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: ‘Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability’ by Park et al.

Alexander

Wang

2012

Hypertens Res

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“…SZ, which contains lignans, such as schizandrin and gomisin A, as main constituents, has been reported to have many biological properties, including hepatoprotective, anti-inflammatory and antitumor activites. [12][13][14][15] In preliminary experiments, SZ was found to inhibit the mouse passive cutaneous anaphylaxis reaction induced by the antigen-IgE complex. However, the antiallergic effect of these components remains to be thoroughly studied.…”

mentioning

confidence: 99%

Inhibitory Effect of Schizandrin on Passive Cutaneous Anaphylaxis Reaction and Scratching Behaviors in Mice

Bae

Trinh

Shin

et al. 2007

Biological & Pharmaceutical Bulletin

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These cells express surface membrane receptors, with high affinity and specificity for IgE. The interaction of antigenbound IgE in surface membrane receptors causes the release of histamine, prostaglandins, leukotrienes and cytokines. 4,5) These cytokines activate chemotaxis and phagocytosis of neutrophils and macrophages. Finally, cytokine-induced reactions cause tissue inflammation. These allergic diseases are now rapidly increasing chronic health problem in most countries.6) Antiallergic agents, such as anti-histamines, steroids and immunosuppressants, have been used against allergic diseases, such as allergic rhinitis, atopic dermatitis, asthma and food allergies, [7][8][9] but improving these diseases is very difficult. Therefore, herbal medicines have been advanced for allergic diseases, and their effectiveness has received increasing attention. 10,11) The fruit of Schizandra chinensis BAILL (SZ, Family Magnoliaceae) has frequently been used as a tonic and astringent agent in traditional Korean, Chinese and Japanese medicines. SZ, which contains lignans, such as schizandrin and gomisin A, as main constituents, has been reported to have many biological properties, including hepatoprotective, anti-inflammatory and antitumor activites. [12][13][14][15] In preliminary experiments, SZ was found to inhibit the mouse passive cutaneous anaphylaxis reaction induced by the antigen-IgE complex. However, the antiallergic effect of these components remains to be thoroughly studied.Therefore, to evaluate the antiallergic activity of SZ, a main constituent, schizandrin, was isolated from the fruit of SZ and its in vivo inhibitory activity against scratching behaviors and passive cutaneous anaphylaxis (PCA) investigated. (Fig. 1) was isolated from the fruits of SZ, according to the previous reports. 16,17) Animals The male ICR mice (20-25 g) and male Sprague-Dawley rats were supplied by the Orient Experimental Animal Breeding Center (Seoul, Korea). All animals were housed in wire cages at 20-22°C and 50Ϯ10% humidity, fed standard laboratory chow (Orient Experimental Animal Breeding Center, Seoul, Korea) and allowed water ad libitum. All procedures relating to the animals and their care conformed to the international guidelines 'Principles of Laboratory Animals Care' (NIH publication no. 85-23, revised 1985). MATERIALS AND METHODS MaterialsMeasurement of PCA Reaction An IgE-dependent cutaneous reaction was measured according to the previous method of Choo et al.18) The male ICR mice were intradermally injected, with 10 mg of anti-DNP IgE, into each of two dorsal skin sites that had been shaved 48 h earlier. The sites were outlined with a water-insoluble red marker. Forty-eight hours later each mouse received an injection of 200 ml of 3% Evans blue in PBS, containing 200 mg of DNP-HAS, via the tail vein. The test agents were orally or intraperitoneally administered 1 h prior to the DNP-HSA injection. Thirty minutes after the DNP-HSA injection, the mice were sacrificed, Pharmacy, Kyung Hee University;1, Hoegi, Korea: and ...

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Inhibition by gomisin C (a lignan from Schizandra chinensis) of the respiratory burst of rat neutrophils

Cited by 50 publications

References 52 publications

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: ‘Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability’ by Park et al.

Inhibitory Effect of Schizandrin on Passive Cutaneous Anaphylaxis Reaction and Scratching Behaviors in Mice

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