Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: ‘Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability’ by Park et al.

Alexander, J. Steven; Wang, Yuping

doi:10.1038/hr.2012.101

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…Recently, S. chinensis fruit extracts and the dibenzocyclooctadiene lignans contained in them have gained attention for their potential role in the treatment of cardiovascular diseases, such as hypertension and myocardial infarction (Alexander and Wang 2012; Chun et al 2014; Park et al 2012a), which corroborates the observed effects of this species in traditional settings. Scientific investigations of the molecular mechanisms behind the observed phenomena have revealed that S. chinensis fruit extracts and its lignans exert cardiovascular protective activity by controlling multiple signalling pathways involved in various biological processes, such as vascular contractility, fibrosis, inflammation, oxidative stress, and apoptosis (Chen et al 2013a; Chun et al 2014).…”

Section: Current Knowledge Of Bioactivities and Pharmacological Applimentioning

confidence: 62%

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

Szopa

Ekiert²

2016

Phytochem Rev

262

215

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Schisandra chinensis Turcz. (Baill.) is a plant species whose fruits have been well known in Far Eastern medicine for a long time. However, schisandra seems to be a plant still underestimated in contemporary therapy still in the countries of East Asia. The article presents latest available information on the chemical composition of this plant species. Special attention is given to dibenzo cyclooctadiene lignans. In addition, recent studies of the biological activity of dibenzocyclooctadiene lignans and schisandra fruit extracts are recapitulated. The paper gives a short resume of their beneficial effects in biological systems in vitro, in animals, and in humans, thus underlining their medicinal potential. The cosmetic properties are depicted, too. The analytical methods used for assaying schisandra lignans in the scientific studies and also in industry are also presented. Moreover, special attention is given to the information on the latest biotechnological studies of this plant species. The intention of this review is to contribute to a better understanding of the huge potential of the pharmacological relevance of S. chinensis.

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Section: Current Knowledge Of Bioactivities and Pharmacological Applimentioning

confidence: 62%

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

Szopa

Ekiert²

2016

Phytochem Rev

262

215

View full text Add to dashboard Cite

show abstract

“…Baill is widely applied in folk medicine of of the Russian Far East, Korea, Japan and northeastern China, and is often considered to be an example of a medicinal plant used as sedative and tonic agent in TCM (Hu et al ., ). Previous phytochemical studies showed that this family is a rich sources of lignans, characterized by schisandrin, schisandrol B, schisantherin A, deoxyschisandrin and schisandrin B as the main constituents responsible for treating disease (Alexander and Wang, ). Lignans present in the plant species under study possess a unique structure, and their biotransformation has not been elucidated in detail.…”

Section: Discussionmentioning

confidence: 99%

Profiling and identification of the absorbed constituents and metabolites of schisandra lignans by ultra‐performance liquid chromatography coupled to mass spectrometry

Sun

Zhang

et al. 2013

Biomedical Chromatography

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Schisandra chinensis Baill grows wild in Russia, China, Korea and Japan, and its fruit has been found to be effective in amnesia and insomnia. It is enriched in schisandra lignans (SL) that are major components responsible for therapeutic action. However, there are no reports on the biotransformation analysis of SL. An ultra-performance liquid chromatography/electrospray-ionization high-definition mass spectrometry (UPLC-Q-TOF-HDMS) method was developed to investigate the metabolism of SL in vivo. MS was performed on a Waters Micromass high-definition system with an electrospray ionization source in positive ion mode and automated MetaboLynx software analysis with excellent MS accuracy and enhanced MS data acquisition. An improved mass defect filter (MDF) method employing both drug and core structure filter templates was applied to the processing of UPLC-Q-TOF-HDMS data for the detection and structural characterization of metabolites. In this study, 30 metabolites were detected and identified in vivo, and demethylation and hydroxylation were confirmed as the primacy metabolic pathway for SL in rat plasma. In conclusion, the presently developed methodology was suitable for biotransformation research of SL and will find wide use in metabolic studies for other herbal medicines.

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“…However, there are few reports on the material basis and mechanism of S. chinensis impacting cardiovascular function. In recent years, S. chinensis fruit extracts have attracted attention because of their potential roles in treating cardiovascular diseases such as myocardial infarction and hypertension (Alexander & Wang, 2012; Panossian & Wikman, 2008; Park et al, 2012). Furthermore, aqueous extract, hexane extract, gomisin A, and gomisin J from S. chinensis have shown relaxant effects on isolated thoracic aorta and mesenteric arteries (Park et al, 2007, 2009, 2012; Rhyu et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Relaxation Effect of Schisandrol A on Isolated Thoracic Aorta and its Mechanism in Rats

Qiu,

Dong,

Wang

et al. 2023

Pharmacognosy Magazine

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Background Schisandra chinensis (S. chinensis) is a drug commonly used in the clinical treatment of cardiovascular diseases in Traditional Chinese Medicine. However, the specific components and mechanisms of its action are still unclear. We screened six kinds of lignans from S. chinensis with high content and found that schisandrol A and schisantherin A had a strong vasorelaxant effect. The purpose of this study was to investigate the relaxation and underlying mechanism of schisandrol A in the isolated thoracic aorta of rats. Materials and Methods Isolated rat endothelium-intact and endothelium-removed thoracic aorta strips were pre-constricted with phenylephrine (PE), and the relaxation of schisandrol A on the strips was observed. Then, the mechanism was explored by pre-incubating the strips with nitric oxide synthetase inhibitor Nɷ-nitro-l-arginine methyl ester (L-NAME), cyclooxygenase inhibitor (indomethacin), potassium channel blockers 4-aminopyridine (4-AP), barium chloride (BaCl2), tetraethylamine (TEA), and glibenclamide, respectively, and changing the calcium concentration in the bath. In addition, expressions of endothelial nitric oxide synthetase (eNOS) mRNA and protein in rat thoracic aorta were detected. Results Schisandrol A induced both endothelium-dependent and endothelium-independent relaxation of isolated thoracic aorta strips of rats, and the mechanism might be related to promoting the synthesis of NO, inhibiting Ca2+ release from the sarcoplasmic reticulum, and blocking the Ca2+ channels. Conclusion These discoveries may provide a theoretical basis for the traditional application of S. chinensis to treat cardiovascular disease.

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Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: ‘Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability’ by Park et al.

Cited by 12 publications

References 13 publications

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

Profiling and identification of the absorbed constituents and metabolites of schisandra lignans by ultra‐performance liquid chromatography coupled to mass spectrometry

Relaxation Effect of Schisandrol A on Isolated Thoracic Aorta and its Mechanism in Rats

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