Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study*1

Budoff, Matthew J.; Takasu, Junichiro; Flores, Ferdinand; Niihara, Yutaka; Lü, Bin; Lau, Benjamin H.S.; Rosén, Robert; Amagase, Harunobu

doi:10.1016/j.ypmed.2004.04.012

Cited by 110 publications

(124 citation statements)

References 33 publications

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“…There are a number of methodological considerations that are required for the evaluation of sequential imaging. A recent review of the relevant methodologies has recently been published by Taylor et al 143 Currently, there are only 4 randomized, controlled trials evaluating CACP progression, 130,142,144,145 and these types of studies have not yet been reported with MDCT. The theoretical ability of statin therapy to slow or reverse CACP has demonstrated mixed results in the available literature, raising some doubts about using this tool for tracking progression of atherosclerosis.…”

Section: Tracking Progression Of Subclinical Atherosclerosismentioning

confidence: 99%

Assessment of Coronary Artery Disease by Cardiac Computed Tomography

Budoff¹,

Achenbach²,

Blumenthal³

et al. 2006

Circulation

1,232

382

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Section: Tracking Progression Of Subclinical Atherosclerosismentioning

confidence: 99%

Assessment of Coronary Artery Disease by Cardiac Computed Tomography

Budoff¹,

Achenbach²,

Blumenthal³

et al. 2006

Circulation

1,232

382

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“…Aged garlic extracts (AGE), which have antioxidant properties, have the ability to reduce several cardiovascular risk factors, such as BP, serum cholesterol, and platelet aggregation and adhesion, while stimulating nitric oxide generation in endothelial cells (60). As a result, these may improve peripheral circulation.…”

Section: Other Interventionsmentioning

confidence: 99%

Reducing the Burden of Cardiovascular Calcification in Patients with Chronic Kidney Disease

Qunibi

2005

Journal of the American Society of Nephrology

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Patients with chronic kidney disease (CKD) have a higher burden of atherosclerotic coronary artery disease compared with age-and gender-matched individuals with normal renal function. Cardiovascular calcification (CVC), a marker of atherosclerosis, is also more prevalent in these patients and is associated with serious clinical consequences. The pathogenesis of CVC is complex and includes factors that promote calcification and others that inhibit calcification. Thus, multiple therapeutic interventions should be used simultaneously to reduce the burden of calcification in patients with CKD. Thus far, interventional attempts have focused on curtailing the effects of factors that promote calcification such as management of known traditional factors for atherosclerotic coronary artery disease and on adopting specific approaches to normalize mineral metabolism, deliver adequate dialysis, and control serum cholesterol level. By contrast, interventions that may bolster the effects of inhibitors of calcification have not yet been studied well but are beginning to attract attention. Ideally, the goal of interventions is not only to slow or halt progression of calcification but also to reverse pre-existing calcification. Whether this goal is achievable is not currently known. This review examines the potential of various therapeutic interventions in reducing the CVC burden in patients with CKD. Moreover, the review is intended to stimulate more research in this area because the efficacy of these interventions has not been examined in controlled clinical trials.

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“…Moreover, adherence to fibrinogen was potently inhibited at all levels of supplementation. Three clinical trials were related to coronary artery disease (CAD) patients: the effect of 4 ml/day of AGE was evaluated in 23 subjects [38], while Sobenin et al [39] investigated the effect of allicor (garlic powder) in 51 subjects, both during a period of one year. However, Williams et al [40] assessed 2.4 g/day of AGE only during two weeks.…”

Section: Resultsmentioning

confidence: 99%

“…The main outcomes of these studies consisted of BP, lipids profile, endothelial function, oxidative stress, inflammatory biomarkers, and coronary artery calcification (CAC), platelet aggregation and adhesion just as changes in 10 years prognostic risk of myocardial infarction and sudden death. Within lipids profile measured by the two interventions [38,39,40], LDLc and TC parameters were significantly decreased after allicor treatments [39]. Reduction of CAC progression was detected in the study that assessed it [38] (table 3).…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Carbohydrates, Active Lipids and Nitrogen Compounds

Pastor-Villaescusa

Rangel-Huerta²,

Aguilera³

et al. 2015

Ann Nutr Metab

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Background/Aims: The prevalence of cardiovascular diseases (CVD) is rising and it is the prime cause of death in all developed countries. Bioactive compounds (BACs) can play a role in CVD prevention and treatment. To examine the scientific evidence supporting BACs groups' efficacy in CVD prevention and treatment, we conducted a systematized review. Methods: All available information on Medline, LILACS and EMBASE; all randomized controlled trials (RCTs) with prospective, parallel or crossover designs in humans in which the BACs effect was compared with that of placebo/control. Vascular homeostasis, blood pressure, endothelial function, oxidative stress and inflammatory biomarkers were considered primary outcomes. Results: We selected 26 articles, verifying their quality based on the Scottish Intercollegiate Guidelines Network, establishing diverse quality levels of scientific evidence according to the design and bias risk of a study. Grades of recommendation were included, depending on the evidence strength of antecedents. Conclusions: Evidence shows that certain BACs' derivative from active lipids and nitrogen compounds, mainly from horse chestnut seed extract, sterol plants, allium derivatives, and certain doses of beta-glucans, can be helpful in decreasing the prevalence of CVD risk factors. However, further rigorous evidence is necessary to support and prove BACs' effect on CVD prevention and treatment.

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Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study*1

Cited by 110 publications

References 33 publications

Assessment of Coronary Artery Disease by Cardiac Computed Tomography

Assessment of Coronary Artery Disease by Cardiac Computed Tomography

Reducing the Burden of Cardiovascular Calcification in Patients with Chronic Kidney Disease

A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Carbohydrates, Active Lipids and Nitrogen Compounds

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