Inhibiting microRNA-142–5p improves learning and memory in Alzheimer’s disease rats via targeted regulation of the PTPN1-mediated Akt pathway

Liang, Weiwei; Xie, Zhuojun; Liao, D; Liu, Ying; Li, Zhengyu; Zhao, Yuanru; Li, Xiaobo; Dong, Manli

doi:10.1016/j.brainresbull.2022.02.016

Cited by 9 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also discovered a significant decrease in hsa-miR-142-5p expression in male AD patients. Hsa-miR-142-5p had been previously related to spatial learning and memory in AD animal models [64,65][65,66], suggesting a potential target for AD treatment.…”

Section: Discussionmentioning

confidence: 99%

The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

Llera-Oyola,

Carceller,

Andreu

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Alzheimer's disease (AD) is the most frequent cause of dementia and its incidence is expected to rise as the life expectancy of the population increases. Sex-based differences in AD development have been described, although there are still uncertainties on the role of biological sex in molecular mechanisms of the disease. The study of sex-specific expression profiles of regulatory elements, such as microRNAs (miRNAs), could contribute to a more accurate diagnosis and treatment of the disease. Methods: We conducted a systematic review identifying five studies of microRNA expression in AD that incorporated the biological sex of the samples published in the Gene Expression Omnibus (GEO) repository. Differential expression analyses were performed for each study, considering both disease and biological sex of patients. Subsequently, results were integrated with a meta-analysis methodology. Finally, functional enrichment of the meta-analyses results was performed to establish an association between altered miRNA expression and relevant terms of the Gene Ontology (GO). Results: Meta-analyses of miRNAs expression in blood samples revealed 16 and 22 miRNAs altered in females and males, respectively. Moreover, 9 miRNAs were commonly overexpressed in both sexes, unveiling common miRNAs dysregulation profiles. In contrast, functional enrichment revealed sex-differences in biological processes altered. In males, most of the affected processes were related to ubiquitination, regulation of different kinase activities and apoptotic processes; but in females were linked to RNA splicing and translation. Meta-analyses of brain samples also revealed some alterations in miRNAs expression (6 in females and 4 in males). The unique miRNA altered in both sexes (miR-767-5p) was underexpressed in both males and females. Nonetheless, the functional enrichment analysis did not reveal any affected biological process. Conclusions: Sex-specific meta-analyses allowed for the detection of differentially expressed miRNAs in females and males. Identification of deregulated miRNAs highlighted the relevance of the sex information in biomedical data. Further studies centered on miRNA regulation should meet criteria for comparability and standardization of information.

show abstract

Section: Discussionmentioning

confidence: 99%

The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

Llera-Oyola,

Carceller,

Andreu

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…MiR‐429‐SOX2 axis and miR‐429‐BCL‐2 axis promoted cell apoptosis in Aβ 25‐35 ‐induced primary mouse cortical neurons 80 . Similarly, the expression level of miR‐142‐5p was increased in the AD animal models (APPswe/PS1dE9 double transgenic mice and injection of Aβ 42 oligomer once into the lateral ventricle of rats) 81,82 . BAI3 was a direct target of miR‐142‐5p, 81 and PTPN1 was also a direct target of miR‐142‐5p 82 .…”

Section: Abnormally Expressed Ncrnas In Ad Animal Models In Regulatin...mentioning

confidence: 92%

“… 82 MiR‐142‐5p‐PTPN1 axis and MiR‐142‐5p‐BAI3 axis promoted cell apoptosis in AD rats and Aβ 42 ‐induced HT‐22 cells, respectively. 81 , 82 In contrast, miR‐107 was downregulated in APP/PS1 double transgenic mice 83 and 6‐hydroxydopamine (6‐OHDA)‐insulted mice. 84 PDCD10 was a direct target of miR‐107.…”

Section: Abnormally Expressed Ncrnas In Ad Animal Models In Regulatin...mentioning

confidence: 93%

“… 80 Similarly, the expression level of miR‐142‐5p was increased in the AD animal models (APPswe/PS1dE9 double transgenic mice and injection of Aβ 42 oligomer once into the lateral ventricle of rats). 81 , 82 BAI3 was a direct target of miR‐142‐5p, 81 and PTPN1 was also a direct target of miR‐142‐5p. 82 MiR‐142‐5p‐PTPN1 axis and MiR‐142‐5p‐BAI3 axis promoted cell apoptosis in AD rats and Aβ 42 ‐induced HT‐22 cells, respectively.…”

Section: Abnormally Expressed Ncrnas In Ad Animal Models In Regulatin...mentioning

confidence: 97%

“…BAI3 was a direct target of miR‐142‐5p, 81 and PTPN1 was also a direct target of miR‐142‐5p 82 . MiR‐142‐5p‐PTPN1 axis and MiR‐142‐5p‐BAI3 axis promoted cell apoptosis in AD rats and Aβ 42 ‐induced HT‐22 cells, respectively 81,82 . In contrast, miR‐107 was downregulated in APP/PS1 double transgenic mice 83 and 6‐hydroxydopamine (6‐OHDA)‐insulted mice 84 .…”

Section: Abnormally Expressed Ncrnas In Ad Animal Models In Regulatin...mentioning

confidence: 99%

See 2 more Smart Citations

NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease

Li,

Jin,

Tan

et al. 2023

CNS Neurosci Ther

View full text Add to dashboard Cite

AimsThe aim of this review is to systematically summarize and analyze the noncoding RNAs (ncRNAs), especially microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), in the cell apoptosis among Alzheimer's disease (AD) in recent years to demonstrate their value in the diagnosis and treatment of AD.MethodsWe systematically summarized in vitro and in vivo studies focusing on the ncRNAs in the regulation of cell apoptosis among AD in PubMed, ScienceDirect, and Google Scholar.ResultsWe discover three patterns of ncRNAs (including ‘miRNA‐mRNA’, ‘lncRNA‐miRNA‐mRNA’, and ‘circRNA‐miRNA‐mRNA’) form the ncRNA‐based regulatory networks in regulating cell apoptosis in AD.ConclusionsThis review provides a future diagnosis and treatment strategy for AD patients based on ncRNAs.

show abstract

Hederagenin Upregulates PTPN1 Expression in Aβ-Stimulated Neuronal Cells, Exerting Anti-Oxidative Stress and Anti-Apoptotic Activities

Li,

Wang,

2023

J Mol Neurosci

View full text Add to dashboard Cite

Inhibiting microRNA-142–5p improves learning and memory in Alzheimer’s disease rats via targeted regulation of the PTPN1-mediated Akt pathway

Cited by 9 publications

References 33 publications

The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

The role of microRNAs in understanding sex-based differences in Alzheimer’s disease

NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease

Hederagenin Upregulates PTPN1 Expression in Aβ-Stimulated Neuronal Cells, Exerting Anti-Oxidative Stress and Anti-Apoptotic Activities

Contact Info

Product

Resources

About