Hederagenin Upregulates PTPN1 Expression in Aβ-Stimulated Neuronal Cells, Exerting Anti-Oxidative Stress and Anti-Apoptotic Activities

Li, Ke; Wang, Yu; Ni, Hongzao

doi:10.1007/s12031-023-02160-9

Cited by 2 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By utilizing the Aβ-stimulated mouse hippocampal cell line HT22 cells and primary neuronal cells isolated from the mouse hippocampus to establish a cellular model of AD, HG alleviated the Aβ-induced increase in ROS accumulation and decline in SOD activity, and reduced the Aβ-induced elevation in the apoptotic rate and caspase-3 activity. The anti-oxidative stress and anti-apoptotic activities of HG were accomplished via promoting the activation of the PTPN1/AKT signaling ( Li et al, 2023 ).…”

Section: Effects and Mechanisms Of Hg And Its Derivativesmentioning

confidence: 99%

An updated review of the pharmacological effects and potential mechanisms of hederagenin and its derivatives

Zhang,

Li,

Liu

2024

Front. Pharmacol.

View full text Add to dashboard Cite

Hederagenin (HG) is a natural pentacyclic triterpenoid that can be isolated from various medicinal herbs. By modifying the structure of HG, multiple derivatives with superior biological activities and safety profiles have been designed and synthesized. Accumulating evidence has demonstrated that HG and its derivatives display multiple pharmacological activities against cancers, inflammatory diseases, infectious diseases, metabolic diseases, fibrotic diseases, cerebrovascular and neurodegenerative diseases, and depression. Previous studies have confirmed that HG and its derivatives combat cancer by exerting cytotoxicity, inhibiting proliferation, inducing apoptosis, modulating autophagy, and reversing chemotherapy resistance in cancer cells, and the action targets involved mainly include STAT3, Aurora B, KIF7, PI3K/AKT, NF-κB, Nrf2/ARE, Drp1, and P-gp. In addition, HG and its derivatives antagonize inflammation through inhibiting the production and release of pro-inflammatory cytokines and inflammatory mediators by regulating inflammation-related pathways and targets, such as NF-κB, MAPK, JAK2/STAT3, Keap1-Nrf2/HO-1, and LncRNA A33/Axin2/β-catenin. Moreover, anti-pathogen, anti-metabolic disorder, anti-fibrosis, neuroprotection, and anti-depression mechanisms of HG and its derivatives have been partially elucidated. The diverse pharmacological properties of HG and its derivatives hold significant implications for future research and development of new drugs derived from HG, which can lead to improved effectiveness and safety profiles.

show abstract

Section: Effects and Mechanisms Of Hg And Its Derivativesmentioning

confidence: 99%