Abstract:The changes in inhibin immunostaining in the gonads during the annual reproductive cycle of both sexes of the prairie dog are described. No inhibin immunostaining was found in primary or secondary follicles of the ovary. Theca and granulosa cells of preovulatory Graafian follicles found in January and February stained for inhibin. Corpora lutea of both pregnant and non-pregnant females stain more densely for inhibin than follicles. Inhibin staining is present in luteal cells for at least 4 months during regres… Show more
“…Inhibin (INH) is a dimeric glycoprotein hormone conserved among species (Foreman 2007) and synthesized in male mammals by both Sertoli cells (SCs) and Leydig cells (LCs) (Maddoks and Sharpe 1989;Hayes et al 1998). Inhibin is composed of an a-subunit and one or two possible b-subunits, b A or b B (Kommoss et al 2000).…”
Section: Introductionmentioning
confidence: 99%
“…Inhibin (INH) is a dimeric glycoprotein hormone conserved among species (Foreman 2007) and synthesized in male mammals by both Sertoli cells (SCs) and Leydig cells (LCs) (Maddoks and Sharpe 1989; Hayes et al. 1998).…”
Formalin-fixed, paraffin-embedded sections from 32 canine pairs of testes were immunohistochemically examined for Inhibin-α (INHα). Samples were subdivided into two groups (group 1, neonates; group 2, puppies and adults) and results statistically compared. Inhibin-α was significantly expressed only in Sertoli cells of neonatal testes, while in Leydig cells it was expressed without significant difference between groups. These results suggest that, in dogs, INHα expression switches from Sertoli to Leydig cells during testicular maturation and that, in adult, Leydig cells represent the main source of INHα.
“…Inhibin (INH) is a dimeric glycoprotein hormone conserved among species (Foreman 2007) and synthesized in male mammals by both Sertoli cells (SCs) and Leydig cells (LCs) (Maddoks and Sharpe 1989;Hayes et al 1998). Inhibin is composed of an a-subunit and one or two possible b-subunits, b A or b B (Kommoss et al 2000).…”
Section: Introductionmentioning
confidence: 99%
“…Inhibin (INH) is a dimeric glycoprotein hormone conserved among species (Foreman 2007) and synthesized in male mammals by both Sertoli cells (SCs) and Leydig cells (LCs) (Maddoks and Sharpe 1989; Hayes et al. 1998).…”
Formalin-fixed, paraffin-embedded sections from 32 canine pairs of testes were immunohistochemically examined for Inhibin-α (INHα). Samples were subdivided into two groups (group 1, neonates; group 2, puppies and adults) and results statistically compared. Inhibin-α was significantly expressed only in Sertoli cells of neonatal testes, while in Leydig cells it was expressed without significant difference between groups. These results suggest that, in dogs, INHα expression switches from Sertoli to Leydig cells during testicular maturation and that, in adult, Leydig cells represent the main source of INHα.
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