Inherited copper toxicosis in Bedlington terriers

Robertson, H. M.; Studdert, Virginia P.; Reuter, R

doi:10.1111/j.1751-0813.1983.tb05971.x

Cited by 21 publications

(15 citation statements)

References 6 publications

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“…Affected dogs may exhibit various clinical signs associated with liver disease, and, in addition, a few have intravascular haemolysis (Hardy and Stevens 1977;Twedt et a1 1979). Robertson et a/ (1983) have recently described copper storage disease in 4 Bedlington terriers in Australia and we report here an additional case in which the presenting complaint was intravascular haemolysis.…”

Section: Introductionmentioning

confidence: 73%

Copper storage disease with intravascular haemolysis in a Bedlington terrier

1983

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A 5-year-old male Bedlington terrier was found to have haemoglobinuria from intravascular haemolysis. The owners reported also recent vomiting, occasional diarrhoea, reduced activity and increased drinking and urination. A diagnosis of inherited copper storage disease, as previously described in this breed, was established by demonstrating characteristic light and electron microscopic changes and copper content of 7, 717 micrograms/g in biopsied liver. Treatment by chelation with d-penicillamine and a low copper diet was instituted and the dog remains well 10 months later. Intravascular haemolysis is rare in dogs and an uncommon finding in Bedlington terriers with copper storage disease.

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Section: Introductionmentioning

confidence: 73%

Copper storage disease with intravascular haemolysis in a Bedlington terrier

1983

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“…The most common toxic injury causing CH in dogs is a consequence of hepatic copper (Cu) excess . Copper‐associated CH (CuCH) may develop in any breed, including mixed breeds, but the Bedlington Terrier (BT), Dalmatian, Labrador Retriever (LR), Doberman Pinscher, and West Highland White Terrier are predisposed.…”

Section: Etiologymentioning

confidence: 99%

ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs

Webster

Cullen

Penninck

et al. 2019

Veterinary Internal Medicne

198

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This consensus statement on chronic hepatitis (CH) in dogs is based on the expert opinion of 7 specialists with extensive experience in diagnosing, treating, and conducting clinical research in hepatology in dogs. It was generated from expert opinion and information gathered from searching of PubMed for manuscripts on CH, the Veterinary Information Network for abstracts and conference proceeding from annual meetings of the American College of Veterinary Medicine and the European College of Veterinary Medicine, and selected manuscripts from the human literature on CH. The panel recognizes that the diagnosis and treatment of CH in the dog is a complex process that requires integration of clinical presentation with clinical pathology, diagnostic imaging, and hepatic biopsy. Essential to this process is an index of suspicion for CH, knowledge of how to best collect tissue samples, access to a pathologist with experience in assessing hepatic histopathology, knowledge of reasonable medical interventions, and a strategy for monitoring treatment response and complications.

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“…Inherited copper toxicosis was first identified in Bedlington terrier in USA, in 1975(Hardy et al 1975 and has since been reported in other countries including Australia (Eriksson 1983;Robertson et al 1983;Kelly et al 1984). This disease is an inherited autosomal recessive disorder characterized by a progressive accumulation of copper, predominantly in the liver (Hardy 1984;Johnson et al 1980).…”

Section: Introductionmentioning

confidence: 93%