2007
DOI: 10.1007/s12041-007-0039-2
|View full text |Cite
|
Sign up to set email alerts
|

Prevalence of the exon 2 deletion of the COMMD1 gene in Australian Bedlington terriers

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
7
0

Year Published

2011
2011
2016
2016

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(7 citation statements)
references
References 12 publications
(10 reference statements)
0
7
0
Order By: Relevance
“…Two alleles were present in the Bedlington terrier population, and allele 2 cosegregated with BTCT. The frequency of the disease-associated allele was very high in the European, American, and Australian populations and varied from 0.31 to 0.5 (Holmes et al 1998; Lee et al 2007; Rothuizen et al 1999; Yuzbasiyan-Gurkan et al 1997). Whereas implementation of the microsatellite marker test in the breeding programs was an important step forward in decreasing the disease incidence within the Bedlington terrier populations, the search for the causal gene continued.…”
Section: Discovery Of the Copper Toxicosis Gene In The Bedlington Termentioning
confidence: 99%
See 1 more Smart Citation
“…Two alleles were present in the Bedlington terrier population, and allele 2 cosegregated with BTCT. The frequency of the disease-associated allele was very high in the European, American, and Australian populations and varied from 0.31 to 0.5 (Holmes et al 1998; Lee et al 2007; Rothuizen et al 1999; Yuzbasiyan-Gurkan et al 1997). Whereas implementation of the microsatellite marker test in the breeding programs was an important step forward in decreasing the disease incidence within the Bedlington terrier populations, the search for the causal gene continued.…”
Section: Discovery Of the Copper Toxicosis Gene In The Bedlington Termentioning
confidence: 99%
“…In an American Bedlington terrier pedigree, it was confirmed that C04107 allele 1 was linked to the exon 2 deletion, implying that direct analysis for the exon 2 deletion would be the only reliable genetic test for copper toxicosis in the Bedlington (Favier et al 2005; Lee et al 2007; van de Sluis et al 2003). The presence of the new haplotype in the American Bedlington terriers raised the question whether this haplotype had a different genetic origin, or occurred due to a recombination event between the microsatellite marker and the exon 2 deletion (van de Sluis et al 2003).…”
Section: Discovery Of the Copper Toxicosis Gene In The Bedlington Termentioning
confidence: 99%
“…In particular, MT-3 is specifically expressed in brain and exhibits enzyme activity as a growth inhibitory factor of neurons 11 . The fourth group includes a novel Cu-regulating protein that was recently characterized, i.e ., the Cu metabolism gene Murr1 (mouse U2af1-rs1 region 1) domain (Commd1) 12 13 . However, little is known about the actual role of Commd1 14 15 .…”
mentioning
confidence: 99%
“…39) The dysfunction of Commd1 causes Cu toxicosis that results from abnormal Cu accumulation in the liver of Bedlington terriers. [40][41][42][43][44][45] Whether Commd1 is directly or indirectly involved in Cu homeostasis is still a controversy.…”
Section: Introductionmentioning
confidence: 99%