Inherited Bleeding Disorders in the Newborn Infant

Barnard, Dorothy

doi:10.1016/s0095-5108(18)30922-9

Cited by 4 publications

(1 citation statement)

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“…The vitamin-K-dependent coagulation factors, prothrombin and factors VII, IX and X, have been shown to be low in the neonatal period [1][2][3]. Like other vitamin-K-dependent factors, protein C is produced in the liver and secreted into the blood circulation as an enzyme precursor of vitamin-K-depen dent serine protease with 9 y-carboxylglutamic acid residues, and closely related with the primary amino acid sequence in the other vitamin-K-dependent factors [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Protein C in the Neonatal Period

Takahashi

Kinoshita²,

Niinomi³

et al. 1989

Pathophysiol Haemos Thromb

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Protein-C activity and antigen were measured in 141 full-term infants during the first month of life. The levels of both protein-C activity and antigen were about one third the level for normal adults in cord blood, and significantly lower than the cord blood during the 1st to 2nd days of life. They increased with age progressively, but did not reach the lowest limit in normal adults even in the first month. The low ratio of protein-C activity and antigen was demonstrated in some infants within the first 4 days of life. The precipitin arc of neonatal infants, which had a discrepancy between protein-C activity and antigen levels, showed an anodal shift upon agarose gel electrophoresis in the presence of Ca²⁺. The abnormal protein C in the neonatal period may be regarded as protein induced by vitamin-K absence or antagonist.

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Section: Introductionmentioning

confidence: 99%