Inheritance of serum cholesterol and its relation to body weight in white mice

Eapen, K. J.; Goswami, Omkar; Pillai, Sandhya

doi:10.1007/bf02984164

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…The lack of phenotypic correlation between body mass and serum cholesterol concentration agrees with the findings of Dunnington et al (1977), but it is in contrast to those of Eapen et al (1971). Phenotypic correlations between body mass and serum cholesterol concentration of .37 for females and .45 for males were reported (Eapen et al, 1971).…”

Section: Discussionsupporting

confidence: 80%

“…Cholesterol concentrations for males and females (133.3 and 95.1 mg/dL) were greater than the values reported by Dunnington et al ( 198 l a ) in the control line of their selection experiment for cholesterol. However, the values in the present study were just 63 and 50% of the values reported by Eapen et al (1971) (Land, 1973;Joakimsen and Baker, 1977;Eisen, 1978 confounded with a counteracting negative maternal effect when mice are reared in larger litters. The positive phenotypic correlation ( .…”

Section: Discussioncontrasting

confidence: 66%

“…Phenotypic correlations between body mass and serum cholesterol concentration of .37 for females and .45 for males were reported (Eapen et al, 1971). The genetic relationship seems t o be positive and the environmental relationship negative between body mass and serum cholesterol, thus explaining phenotypic correlation estimates near zero.…”

Section: Discussionmentioning

confidence: 94%

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Serum cholesterol concentration of mice selected for litter size and its relationship to litter size and testis mass

Ribeiro

Kittok

Nielsen

1994

Journal of Animal Science

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This study assessed the genetic relationship between litter size and serum cholesterol concentration and between litter size and testis mass in mice. Mice were from a long-term experiment in which selection had occurred for 21 generations in three replicated lines per criterion of selection (LS = selection t o increase litter size based on number born; LC = unselected control). Thereafter, random mating within lines was practiced. Serum cholesterol concentrations were evaluated in female and male mice from two replicates at Generation 29 and one replicate at Generation 30. Body weights and blood samples were collected from primiparous females 8 d after weaning their pups. Data from males were collected as they came out of breeding cages. In addition, the testes were excised, stripped clean of connective tissue and the epididymides, and weighed. Means for body mass of females and males, serum cholesterol, number born, and testis mass were as follows: 35.2 vs 32.5 g ( P < .09), 33.9 vs 30.7 g ( P < .08), 117.5 vs 110.5 mg/dL ( P < .08), 14.0 vs 10.3 pups ( P < .04), and 126 vs 122 mg, respectively, for LS and LC. Serum cholesterol was greater in males than in females (133.3 vs 95.1 mg/dL; P < .001), but there was no interaction between sex and selection criterion. Serum cholesterol concentration was not correlated phenotypically t o number born or body mass, but it had a small negative relationship with testis mass. Therefore, we concluded that selection for litter size tended to increase serum cholesterol in addition to the increase in number born but did not change testis mass.

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Section: Discussionsupporting

confidence: 80%