Strain differences in response to dietary cholesterol by JAX rabbits: Correlation with esterase patterns

Zutphen, L.F.M. van; Fox, R. R.

doi:10.1016/0021-9150(77)90070-3

Cited by 58 publications

(22 citation statements)

References 26 publications

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“…This substantiates earlier reports (Van Zutphen and Fox, 1977;Van Zutphen and Den Bieman, 1981) which suggest that plasma esterase patterns predict the susceptibility to dietary cholesterol. However, the results obtained with the Wistar rats are not completely in line with those found in the inbred strains.…”

Section: Discussionsupporting

confidence: 92%

“…The cholesterolemic response was low in 6 out of 7 inbred rat strains displaying the Es-1 zone, whereas absence of the enzyme was associated with the development of high degrees of hypercholesterolemia after cholesterol feeding in 2 out of 3 inbred rat strains (Van Zutphen and Den Bieman, 1981). Similar results were obtained in a study with six inbred strains of rabbits (Van Zutphen and Fox, 1977) where the cholesterolemic response to dietary cholesterol correlated with the Est-2 genotype. The Est-2 locus of the rabbit is assumed to be homologous with the Es-1 locus in the rat (Fox and Van Zutphem 1979).…”

Section: Experiments With Humanssupporting

confidence: 79%

“…Plasma esterases may also be involved in cholesterol metabolism. In inbred strains of rabbits (Van Zutphen and Fox, 1977) and rats (Okamoto et aL, 1972;Van Zutphen and Den Bierman, 1981) it was found that variation in the response of plasma cholesterol level to dietary cholesterol was associated with a genetically determined variation in plasma esterases. A fast moving esterase zone was present in the plasma zymogram of hyporesponsive strains, but not in that of hyperresponsive strains.…”

Section: Introductionmentioning

confidence: 99%

“…The esterase pattern after gel electrophoresis (Van Zutphen and Fox, 1977;Van Zutphen and Den Bieman, 1981) only gives qualitative information. Therefore, the present study was carried out in an attempt to correlate absolute levels of plasma total :[:Correspondence to be addressed to: Dr. A. C. Beynen, Department of Laboratory Animal Science, State University, Yalelaan 1, 3508 TD Utrecht, The Netherlands.…”

Section: Introductionmentioning

confidence: 99%

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Arylesterase activities in the plasma of rats, rabbits and humans on low- and high-cholesterol diets

Beynen

Weinans

Katan

1984

Comparative Biochemistry and Physiology Part B: Comparative Bio

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Abstract--1. Arylesterase activities were measured with fl-naphthylpropionate and/or ~-naphthylacetate as substrate in the plasma of rats, rabbits and humans on low-and high-cholesterol diets.2. The plasma esterase activities measured with ~-naphthylacetate were similar in rats, rabbits and humans. With fl-naphthylpropionate as a substrate, rabbits were found to have a markedly higher esterase activity than rats and humans.3. Basal plasma esterase activity was significantly higher in an inbred rat strain which is hyporesponsive to dietary cholesterol than in a hyperresponsive strain.4. In rats, but not in humans and rabbits, plasma esterase activity was significantly increased by a high-cholesterol diet.5. In individual humans and random-bred rabbits and rats there was no association between initial plasma total esterase activity and the subsequent plasma cholesterol response to cholesterol feeding.6. We suggest that arylesterases are associated with cholesterol metabolism and with the response to dietary cholesterol in rats; evidence for such a role in rabbits and humans is, however, inconclusive.

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Section: Discussionsupporting

confidence: 92%

Section: Experiments With Humanssupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Arylesterase activities in the plasma of rats, rabbits and humans on low- and high-cholesterol diets

Beynen

Weinans

Katan

1984

Comparative Biochemistry and Physiology Part B: Comparative Bio

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“…33 The effect is much greater than the differences among inbred and recombinant strains of mice 34 and among swine with apoB variants. 35 Physiological mechanisms associated with dietary responsiveness have been studied extensively in squirrel monkeys, 36 African green monkeys, 37 rhesus monkeys, 38 and baboons, 3 but no single gene affecting responsiveness to dietary cholesterol has been identified in any nonhuman primate.…”

Section: Nature Of the Major Locus For Cholesterol Responsivenessmentioning

confidence: 99%

Two Major Loci Control Variation in β-Lipoprotein Cholesterol and Response to Dietary Fat and Cholesterol in Baboons

Rainwater

Kammerer

Hixson

et al. 1998

ATVB

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Abstract-We explored the genetic control of cholesterolemic responses to dietary cholesterol and fat in 575 pedigreed baboons. We measured cholesterol in ␤-lipoproteins (low density lipoprotein cholesterol [LDLC]) in blood drawn from baboons while they were consuming a baseline (low in cholesterol and fat) diet, a high-saturated fat (lard) diet, and a high-cholesterol, high-saturated fat diet. In addition to baseline levels (LDLC Base ), we analyzed two variables for diet response: LDLC RF , which represents the LDLC response to increasing dietary fat (ie, high-fat diet minus baseline), and LDLC RC , which represents the LDLC response to increasing dietary cholesterol level (ie, high-cholesterol, high-fat diet minus high-fat diet). Heritabilities (h 2 ) of the 3 traits were 0.59 for LDLC Base , 0.14 for LDLC RF , and 0.59 for LDLC RC . In addition, LDLC Base and LDLC RC had a significant genetic correlation (ie, G ϭ0.54), suggesting that 1 or more genes exert pleiotropic effects on the 2 traits. Segregation analyses detected a single major locus that accounted for nearly all genetic variation in LDLC RC and some genetic variation in LDLC Base and LDLC RF and confirmed the presence of a different major locus that influences LDLC Base alone. Preliminary linkage analyses indicated that neither locus was linked to the LDL receptor gene, a likely candidate locus for LDLC. Detection of these major loci with large effects on the LDLC response to dietary cholesterol in a nonhuman primate offers hope of detecting and ultimately identifying similar loci that determine LDLC variation in human populations. (Arterioscler Thromb Vasc Biol. 1998;18:1061-1068.)

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A Genetic and Correlation Analysis of Liver Cholesterol Concentration in Rat Recombinant Inbred Strains Fed a High Cholesterol Diet

Bottger

Lankhorst

Lith

et al. 1998

Biochemical and Biophysical Research Communications

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Strain differences in response to dietary cholesterol by JAX rabbits: Correlation with esterase patterns

Cited by 58 publications

References 26 publications

Arylesterase activities in the plasma of rats, rabbits and humans on low- and high-cholesterol diets

Arylesterase activities in the plasma of rats, rabbits and humans on low- and high-cholesterol diets

Two Major Loci Control Variation in β-Lipoprotein Cholesterol and Response to Dietary Fat and Cholesterol in Baboons

A Genetic and Correlation Analysis of Liver Cholesterol Concentration in Rat Recombinant Inbred Strains Fed a High Cholesterol Diet

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