Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

Abstract

An unprecedented alendronate loading capacity was achieved in UiO-66 nanoparticles thanks to the inherent drug anchorages of Zr–O clusters therein.

Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

“…Zhu et al used Zr-based UiO-66 NMOFs (∼70 nm cubical shape by TEM) to deliver Alendronate (AL), a bisphosphate anticancer drug. 161 Cytotoxicity assays in HepG2 and MCF-7 cells showed that AL-UiO-66 NMOFs induced enhanced cell killing than free AL. The delivery of camptothecin (CPT) and its derivative Topotecan (TPT) was achieved by ZIF-8 (∼70 nm) 162 and MIL-100 (∼50−100 nm), 163 respectively.…”

Ag2CO3/UiO-66(Zr) composite with enhanced visible-light promoted photocatalytic activity for dye degradation

“…UiO-66 not only possesses the excellent properties as other MOFs, but also exhibits higher thermostability and chemical stability, thus it has been extensively researched in the fields of catalysis, hydrogen generation, gas storage, drug delivery, etc. [47][48][49][50][51]. Moreover, UiO-66 also demonstrates excellent structural stability in water [52,53], and such stability can even be preserved after modification of active functional groups or introduction of missing-linker defects [54,55].…”

Zn2+‐Triggered Drug Release from Biocompatible Zirconium MOFs Equipped with Supramolecular Gates

“…[ 22 ] The promising mechanical, biocompatible characteristics, and extremely low toxicity of Zr compounds boost the burgeoning biomedical applications of Zr-containing agents, [ 23 ] and signifi cantly Zr-based MOFs possess a wide array of potential applications in controlled drug delivery and storage. [24][25][26] The emergence of pillarenes (or pillararenes) [27][28][29][30][31][32] has been one of the most signifi cant achievements in supramolecular chemistry and materials science over the past 7 years. The superior structures, facile functionalization, and typical host-guest properties of pillarenes stimulated a tremendous upsurge of interest in artifi cial transmembrane channels, [ 33,34 ] drug nanocarriers, [35][36][37][38][39][40] gas sorption, [ 41,42 ] MOFs, [ 43 ] sensing and detection, [ 44 ] stabilization of nanoparticles, biological applications, [ 45,46 ] etc.…”