Inhaled disodium cromoglycate (DSCG) as maintenance therapy in children with asthma: a systematic review

Tasche, Marjolein

doi:10.1136/thorax.55.11.913

Cited by 106 publications

(50 citation statements)

References 46 publications

(32 reference statements)

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“…Sustained-release theophylline has only weak anti-inflammatory and controller efficacy (Evidence B) [110-112, 115, 116] and cromones (nedocromil sodium and sodium cromoglycate) have comparatively low efficacy (Evidence A) [281][282][283][284].…”

Section: Treatment Steps For Achieving Controlmentioning

confidence: 99%

Global strategy for asthma management and prevention: GINA executive summary

Bateman

Ss²,

Barnes³

et al. 2008

European Respiratory Journal

2,643

2,301

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Asthma is a serious health problem throughout the world. During the past two decades, many scientific advances have improved our understanding of asthma and ability to manage and control it effectively. However, recommendations for asthma care need to be adapted to local conditions, resources and services. Since it was formed in 1993, the Global Initiative for Asthma, a network of individuals, organisations and public health officials, has played a leading role in disseminating information about the care of patients with asthma based on a process of continuous review of published scientific investigations. A comprehensive workshop report entitled ''A Global Strategy for Asthma Management and Prevention'', first published in 1995, has been widely adopted, translated and reproduced, and forms the basis for many national guidelines. The 2006 report contains important new themes. First, it asserts that ''it is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained,'' and recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions. The importance of the patient-care giver partnership and guided self-management, along with setting goals for treatment, are also emphasised.

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Section: Treatment Steps For Achieving Controlmentioning

confidence: 99%

Global strategy for asthma management and prevention: GINA executive summary

Bateman

Ss²,

Barnes³

et al. 2008

European Respiratory Journal

2,643

2,301

View full text Add to dashboard Cite

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“…With its three-to fourtimes-daily dosing requirement, its use has decreased in recent years. A review of 24 randomized studies by Tasche et al [17] found insufficient evidence that disodium cromoglycate has a beneficial effect as maintenance treatment in children with asthma.…”

Section: Anti-inflammatory Medicationsmentioning

confidence: 98%

Management of asthma in young children

Sockrider

2002

Curr Allergy Asthma Rep

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Asthma and recurrent airway symptoms in a young child can result in significant morbidity and reduced quality of life. There is significant variability in asthma severity. Even for those who will "outgrow" asthma, regular problems can be minimized with appropriate pharmacotherapy, education, and environmental control. Success with primary prevention through environmental control for children at high risk for asthma has been limited. Avoidance of passive tobacco smoke exposure has primary and secondary prevention benefits. An inhaled short-acting bronchodilator should be available for use as needed. Patients with regular symptoms should receive maintenance anti-inflammatory medication. Add-on therapy can be considered for those with inadequate control on inhaled corticosteroid. Physicians should regularly review drug delivery technique and compliance and provide all patients with a written asthma action plan to guide symptom monitoring and medication use. Physicians should also establish a partnership with the child and family, providing self-management training to enhance skills and confidence.

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“…Following the First Poster, a more detailed description of the systematic review was published in Thorax in 2000 [12].…”

Section: The Thorax Papermentioning

confidence: 99%

Sodium cromoglicate: an ineffective drug or meta‐analysis misused?

Stevens¹,

Edwards

Howell

2007

Pharmaceutical Statistics

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Sodium cromoglicate (SCG) has been available since around 1970 for the treatment of asthma and other allergic disorders in both adults and children. It has been approved for use around the world. Over the period of its development, a number of different formulations were introduced. In 1999, a systematic review of SCG use in childhood asthma was carried out and reported initially as a poster. Further systematic reviews and papers followed from the same authors and finally a Cochrane Collaboration review was published in 2003. All concluded that SCG was ineffective in paediatric asthma. Both the British Thoracic Society Guidelines for the treatment of paediatric asthma and the Model List of Essential Drugs of the WHO now reflect these conclusions. This paper looks carefully at the conclusions of these systematic reviews and raises concerns about the interpretation of the results. These failed to take adequate account of the changes with time in both the formulations used and the age groups examined, and also failed to take adequate note of the totality of information available over all end-points. One primary end-point was based on only four out of the 24 studies included in the review. Rather than having no effect, it is demonstrated that a considerable body of evidence favours SCG compared to placebo and, far from being ineffective, the drug appears to be effective particularly in older children. This article replaces a previously published version. DOI: 10.1002/pst.258.

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Inhaled disodium cromoglycate (DSCG) as maintenance therapy in children with asthma: a systematic review

Cited by 106 publications

References 46 publications

Global strategy for asthma management and prevention: GINA executive summary

Global strategy for asthma management and prevention: GINA executive summary

Management of asthma in young children

Sodium cromoglicate: an ineffective drug or meta‐analysis misused?

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