Inhaled Cisplatin Deposition and Distribution in Lymph Nodes in Stage II Lung Cancer Patients

Darwiche, Kaid; Krauss, Leslie; Huang, Haidong; Zachariadis, George A.; Katsavou, Anna; Hohenforst-Schmidt, Wolfgang; Papaiwannou, Antonis; Vogl, Thomas J.; Freitag, Lutz; Stamatis, G; Zarogoulidis, Konstantinos

doi:10.2217/fon.13.111

Cited by 31 publications

(40 citation statements)

References 30 publications

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“…Previous work illustrates the use of this technology for NP detection in biological tissues. For example in lung cancer, the deposition patterns of cisplatin aerosol therapy in surgically resected stage II lymph nodes was analyzed using hyperspectral imaging [100]. Hyperspectral imaging was also used to analyze the morphology and particle distribution of liposomes encapsulating recombinant human epidermal growth factor [101].…”

Section: Setup For Experimental Evaluationmentioning

confidence: 99%

Evaluation of uptake and distribution of gold nanoparticles in solid tumors

2015

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Although nanotherapeutics offer a targeted and potentially less toxic alternative to systemic chemotherapy in cancer treatment, nanotherapeutic transport is typically hindered by abnormal characteristics of tumor tissue. Once nanoparticles targeted to tumor cells arrive in the circulation of tumor vasculature, they must extravasate from irregular vessels and diffuse through the tissue to ideally reach all malignant cells in cytotoxic concentrations. The enhanced permeability and retention effect can be leveraged to promote extravasation of appropriately sized particles from tumor vasculature; however, therapeutic success remains elusive partly due to inadequate intra-tumoral transport promoting heterogeneous nanoparticle uptake and distribution. Irregular tumor vasculature not only hinders particle transport but also sustains hypoxic tissue kregions with quiescent cells, which may be unaffected by cycle-dependent chemotherapeutics released from nanoparticles and thus regrow tumor tissue following nanotherapy. Furthermore, a large proportion of systemically injected nanoparticles may become sequestered by the reticuloendothelial system, resulting in overall diminished efficacy. We review recent work evaluating the uptake and distribution of gold nanoparticles in pre-clinical tumor models, with the goal to help improve nanotherapy outcomes. We also examine the potential role of novel layered gold nanoparticles designed to address some of these critical issues, assessing their uptake and transport in cancerous tissue.

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Section: Setup For Experimental Evaluationmentioning

confidence: 99%

Evaluation of uptake and distribution of gold nanoparticles in solid tumors

2015

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“…Until now there is only one study that was performed for early stage operable lung cancer with the concept to check the infiltration of the mediastinal lymph nodes from aerosol cisplatin. In this study the aerosol cisplatin was administered before curative surgery [29].…”

Section: Lung Cancer Treatmentmentioning

confidence: 99%

Drug development of Lung Diseases by way of Drug Repurposing; What a Pulmonary Physician can do in the Laboratory

Tsiouda¹,

Hohenforst-Schmidt²,

Sardeli³

et al. 2018

J. Biomed

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Lung diseases are very common among several patients such as; asthma, chronic obstructive pulmonary disease, lung cancer, cystic fibrosis and pulmonary fibrosis. In many of these diseases we already have inhalation therapies, however; for others we have only systematic administration. There are also diseases of the lung that cause pulmonary hypertension and architectural damage to the lung such as; emphysema and bronchiectasis. Several of the drugs currently administered intravenously are being investigated whether they could be transformed and delivered as aerosol therapy. We will present the methodology that can be used and has been used for several drugs.

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“…In an effort to deliver efficiently the necessary drug concentration to the tumor site and prevent systemic adverse effects, the concept of administering local treatment for lung cancer has been explored. Aerosol chemotherapy with cisplatin9, carboplatin8, gemcitabine16, 17, paclitaxel18, doxorubicin19, 20, 5-Fluoracil21 and bevasizumab22 administration has been investigated for safety and efficacy. One of the major parameters was the safety of these agents in the respiratory airways and lung parenchyma, since several of these agents are known to cause adverse effects 23.…”

Section: Introductionmentioning

confidence: 99%

“…Several aerosol production systems have been investigated in an effort to identify the ``ideal`` combination of aerosol generator (jet-nebulizer, ultrasound nebulizer), residual cup design and residual cup loading for several chemotherapeutic agents 14, 25. It has been also observed that the aerosol chemotherapy agents are transported from the alveoli to the system and lymphatic circulation 8, 9. Efficient drug absorption is depended on two major mechanisms the passive and the active transportation.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Aerosol Cisplatin Chemotherapy with Gene Therapy Expressing ABC10 protein in Respiratory System

Hohenforst-Schmidt¹,

Linsmeier²,

Kioumis³

et al. 2014

J. Cancer

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Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. We included the following groups to our work: a) control, b) aerosol vector, c) aerosol vector plus cisplatin, d) aerosol cisplatin, e) intratumoral cisplatin administration, f) intratumoral vector plus cisplatin administration. The results indicate that the aerosol cisplatin group had a long term survival with the intratumoral cisplatin group following. The enhancement of the ABCA family locally to the respiratory system prior to the aerosol cisplatin administration can be used safely and efficiently. Future treatment design of local therapies should include the investigation of local transporters and genes.

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Inhaled Cisplatin Deposition and Distribution in Lymph Nodes in Stage II Lung Cancer Patients

Cited by 31 publications

References 30 publications

Evaluation of uptake and distribution of gold nanoparticles in solid tumors

Evaluation of uptake and distribution of gold nanoparticles in solid tumors

Drug development of Lung Diseases by way of Drug Repurposing; What a Pulmonary Physician can do in the Laboratory

Enhancement of Aerosol Cisplatin Chemotherapy with Gene Therapy Expressing ABC10 protein in Respiratory System

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