Inhalable curcumin formulations by supercritical technology

Kurniawansyah, Firman; Mammucari, Raffaella; Foster, Neil R.

doi:10.1016/j.powtec.2015.04.083

Cited by 37 publications

(15 citation statements)

References 29 publications

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“…Crude curcumin had several strong characteristic peaks at 2 θ = 8.8°, 12.1°, 14.3°, 17.2°, 18.0°, 21.1°, 23.1°, 24.4°, 25.5°, 27.2°, and 28.8°. Similar diffraction peaks were observed in the literature for crude curcumin powder 23,25 . These sharp peaks indicate the crystalline structure of crude curcumin.…”

Section: Resultssupporting

confidence: 88%

“…In addition, ARISE is based on atomization of curcumin mixture into a vessel pressurized with CO 2 . Feed solution is composed of curcumin/polyvinylpyrrolidone (PVP), hydroxypropyl-β-cyclodextrin (HPβCD), or both in organic solvents like methanol, ethanol or acetone 23 . Furthermore, SEDS process is based on precipitation of curcumin from acetone solution in SC-CO 2 .…”

Section: Resultsmentioning

confidence: 99%

“…After exploring the new opportunities offered by supercritical fluid technology, and especially the green processing by SC-CO 2 technology, there has been several efforts to decrease the size of curcumin using SC-CO 2 . So far, solid lipid particles by Particles Generated from Gas Saturated Solution (PGSS) 22 , micronization by Atomized Rapid Injection Solvent Extraction (ARISE) 23,24 , loading nanofibrous silk fibroin by Solution-Enhanced Dispersion via SC-CO 2 (SEDS) 25 , and Precipitation by Pressure Reduction of Gas-Expanded Liquids (PPRGEL) 26 have been employed to decrease the size of curcumin using SC-CO 2 . However, the difficulty in controlling the particle size, the use of organic solvents like acetone, and limited number of food-grade chemicals used during the production are still significant drawbacks of the current techniques.…”

Section: Introductionmentioning

confidence: 99%

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A novel and green nanoparticle formation approach to forming low-crystallinity curcumin nanoparticles to improve curcumin’s bioaccessibility

Ubeyitogullari

Ciftci

2019

Sci Rep

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Health-promoting effects of curcumin are well-known; however, curcumin has a very low bioavailability due to its crystalline structure. The main objective of this study was to develop a novel green nanoparticle formation method to generate low-crystallinity curcumin nanoparticles to enhance the bioavailability of curcumin. Nanoporous starch aerogels (NSAs) (surface area of 60 m2/g, pore size of 20 nm, density of 0.11 g/cm3, and porosity of 93%) were employed as a mold to produce curcumin nanoparticles with the help of supercritical carbon dioxide (SC-CO2). The average particle size of the curcumin nanoparticles was 66 nm. Impregnation into NSAs decreased the crystallinity of curcumin and did not create any chemical bonding between curcumin nanoparticles and the NSA matrix. The highest impregnation capacity was 224.2 mg curcumin/g NSA. Curcumin nanoparticles significantly enhanced the bioaccessibility of curcumin by 173-fold when compared to the original curcumin. The concentration of curcumin in the bioaccessible fraction was improved from 0.003 to 0.125 mg/mL by impregnation of curcumin into NSAs (42-fold). This is a novel approach to produce food grade curcumin nanoparticles with reduced crystallinity and maximize the utilization of curcumin due to increased bioaccessibility.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A novel and green nanoparticle formation approach to forming low-crystallinity curcumin nanoparticles to improve curcumin’s bioaccessibility

Ubeyitogullari

Ciftci

2019

Sci Rep

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“…Unprocessed curcumin has not shown any absorbance at these conditions, while other authors have measured 0.006 µg/ml after dissolution for 12h in water [39] and 0.5 µg/ml after dissolved in saline solution and centrifuged at 12,000 rpm for 10 min (25 °C) [36]. The different conditions and method used explain the different results obtained.…”

Section: Drug Apparent Solubilitymentioning

confidence: 83%

“…The atomized rapid injection solvent extraction (ARISE) method has also been applied for the coprecipitation of curcumin in ternary composites with PVP and cyclodextrins, with very few experiments being carried out with the binary CURC/PVP. As the intended application was pulmonary delivery, microparticles were produced and in some of the images presented it was possible to distinguish curcumin crystals in a porous structure, which indicate that the materials precipitated separately [36][37][38]. Although there are similarities between the SAS and ARISE processes in terms of the role of sc-CO 2 , differences between the mixing mechanism can lead to different results.…”

Section: Take Down Policymentioning

confidence: 99%

Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process

Matos

Prosapio

et al. 2019

Journal of CO2 Utilization

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The poor solubility of curcumin (CURC) in aqueous media leads to a low bioavailability, which prevents its application in pharmaceutical formulations. In this work, the Supercritical Antisolvent process (SAS) was used to produce coprecipitates of CURC and poly (vinyl pyrrolidone) (PVP) from mixtures of ethanol and acetone. The effects of operating parameters: pressure, temperature, solution concentration, drug/polymer mass ratio and solution flow rate were analysed for a 70-30 (v/v) acetone-ethanol mixture. It was found that the composition of acetone in the solvent mixture is the parameter that affects particle size and curcumin recovery the most. The thermal behaviour, crystallinity, molecular interactions, apparent solubility, release profile of the coprecipitates and possible degradation of curcumin were investigated. The results showed that the SAS process is effective in preparing amorphous formulations of CURC/PVP with an apparent solubility of more than 600 times higher than that of the physical mixture of the raw compounds.

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Nano‐in‐Micro Sildenafil Dry Powder Formulations for the Treatment of Pulmonary Arterial Hypertension Disorders: The Synergic Effect of POxylated Polyurea Dendrimers, PLGA, and Cholesterol

Restani

Pires

Baptista

et al. 2020

Part & Part Syst Charact

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POXylated polyurea dendrimer nanoparticles (PURE G4 OOx 48 ) are loaded with sildenafil (SDF) by a supercritical carbon dioxide-assisted (scCO 2 ) impregnation. Further supercritical CO 2 -assisted spray drying (SASD) leads to hybrid nano-in-micro dry powder formulations that are investigated aiming at efficient pulmonary delivery of SDF in pulmonary arterial hypertension treatment. This is the first report of the production of poly(D,L-lactide-coglycolide)-cholesterol (PLGA-Chol) microparticles processed by SASD. The optimized formulation of nano-in-microparticles is composed of PLGA, Chol, and PURE G4 OOx 48 , loaded with SDF solutions in a 77:23 ratio (PLGA-Chol:dendrimer, w/w). The dry powders are fully characterized and found to be highly biodegradable and biocompatible, and the SDF release profile evaluates under different pH values. The median mass average diameter (MMAD) of the nano-in-micro systems varies between 2.57 and 5 µm and the fine particle fraction (FPF) between 36% and 29% for PURE G4 OMeOx 48 [PLGA-Chol] and PURE G4 OEtOx 48 [PLGA-Chol], respectively. The data validate the potential use of these new formulations in inhalation therapy. In vitro studies are also carried out in order to evaluate the effect of the free drug in cell viability and formulations cytotoxicity.

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Inhalable curcumin formulations by supercritical technology

Cited by 37 publications

References 29 publications

A novel and green nanoparticle formation approach to forming low-crystallinity curcumin nanoparticles to improve curcumin’s bioaccessibility

A novel and green nanoparticle formation approach to forming low-crystallinity curcumin nanoparticles to improve curcumin’s bioaccessibility

Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process

Nano‐in‐Micro Sildenafil Dry Powder Formulations for the Treatment of Pulmonary Arterial Hypertension Disorders: The Synergic Effect of POxylated Polyurea Dendrimers, PLGA, and Cholesterol

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