Ingestions of benzydamine-containing vaginal preparations

Ballesteros, Salomé; Ramón, María Fátima; Martínez-Arrieta, Rosa

doi:10.1080/15563650801938670

Cited by 12 publications

(18 citation statements)

References 15 publications

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“…BH preparates are over-the-counter in many countries and misuse reports are increasing [ 5 , 6 ]. In Turkey, BH preparates could be sold without prescription but Ministry of Health of Turkey prohibited selling BH preparates without prescription in 2012 after increased number of abusing cases.…”

Section: Discussionmentioning

confidence: 99%

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Acute Psychotic Symptoms due to Benzydamine Hydrochloride Abuse with Alcohol

Acar

Kalkan

Çetin

et al. 2014

Case Reports in Psychiatry

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Benzydamine hydrochloride is a locally acting nonsteroidal anti-inflammatory drug. Benzydamine hydrochloride overdose can cause stimulation of central nervous system, hallucinations, and psychosis. We presented a young man with psychotic symptoms due to benzydamine hydrochloride abuse. He received a total dose of 1000 mg benzydamine hydrochloride with alcohol for its hallucinative effects. Misuse of benzydamine hydrochloride must be considered in differential diagnosis of first-episode psychosis and physicians should consider possibility of abuse in prescribing.

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Section: Discussionmentioning

confidence: 99%

“…Hallucinations were reported as a frequent symptom after ingestion of benzydamine-containing vaginal preparations [ 5 ]. Doğan et al reported a case report of visual hallucinations after BH overdose (total dose of 250 mg, 14.7 mg/kg) for suicide in a 11-year-old girl [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Psychotic Symptoms due to Benzydamine Hydrochloride Abuse with Alcohol

Acar

Kalkan

Çetin

et al. 2014

Case Reports in Psychiatry

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“…Он был синтезирован в Италии в 1964 г. и запущен в продажу в 1966 г. Бензидамин обладает болеутоляющим, противовоспалительным, местным анестезирующим и жаропонижающим свойствами [4]. Препараты бензидамина продаются во всем мире для симптоматического лечения ЛОР и гинекологических заболеваний [10]. Имеются сведения об антимикробном действии бензидамина, но они отрывочны и немногочисленны [11,12].…”

Section: бензидаминunclassified

Antibacterial Activity of Benzydamine Hydrochloride against Clinical Isolates of Bacteria, isolated from people in Russia and Spain

Владимирович¹,

Константиновна

Иванович

2019

Epidemiology and Vaccine Prevention

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Антибактериальная активность бензидамина гидрохлорида против клинических изолятов бактерий, выделенных от людей в России и Испании Резюме Цель. Изучить антибактериальную активность бензидамина гидрохлорида против клинических изолятов бактерий, выделенных в лечебных учреждениях России, и сравнить полученные данные с данными аналогичного исследования на клинических изолятах бактерий, выделенных в Испании. Материалы и методы. В исследовании использовали клинические изоляты бактерий, относящихся к типичным возбудителям инфекций в отоларингологии и гинекологии: Enterococcus spp., Escherichia coli, Klebsiella pneumoniae, Staphylococcus spp. и Streptococcus spp., выделенные от пациентов лечебных учреждений России; референс-штаммы Escherichia coli, Staphylococcus aureus и Streptococcus agalactiae, полученные из коллекции ATCC; а также штамм Lactobacillus acidophilus, выделенный из пробиотического препарата «Лактобактерин». Антибактериальную активность препарата бензидамина гидрохлорида определяли методом серийных разведений в агаре. Полученные результаты сравнивали с данными испанского исследования по изучению активности бензидамина против клинических изолятов и референс-штаммов, проведенного на базе микробиологического подраз

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“…Relatively little is known about the effects of BZY on the central nervous system. Symptoms such as hallucinations, dizziness and anxiety have been reported as a consequence of unintended systemic ingestion (Gómez‐López et al ; Ballesteros et al ; Settimi et al ; Acar et al ). Most important, there is evidence of recreational use of BZY in various countries, including Brazil, Italy, Poland and Turkey (Anand et al ; Opaleye et al , ; Settimi et al ; Balaban et al ; Barwina et al ).…”

Section: Introductionmentioning

confidence: 99%

Intravenous self‐administration of benzydamine, a non‐steroidal anti‐inflammatory drug with a central cannabinoidergic mechanism of action

et al. 2017

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Benzydamine (BZY) is a non-steroidal anti-inflammatory drug (NSAID) used for the topical treatment of inflammations of the oral and vaginal mucosa. Virtually nothing is known about the central pharmacological actions of BZY. Yet, there are reports of voluntary systemic overdosage of BZY in drug addicts, resulting in a euphoric, hallucinatory state. In the present study, we investigated the reinforcing properties of BZY in a rat selfadministration paradigm. We found that BZY has a powerful reinforcing effect and that this effect is greatly facilitated in animals that already had substance experience, having previously self-administered heroin and cocaine, indicating cross sensitization between BZY and other common drugs of abuse. We then assessed the effect of BZY on Prelimbic Cortexto-Nucleus Accumbens (PLCx-NAcc) glutamatergic transmission, using field recordings in rat parasagittal brain slices. BZY dose-dependently reduced both field excitatory post synaptic potential (fEPSP) amplitude and Paired Pulse Ratio (PPR), suggesting a presynaptic mechanism of action. Similarly to the in vivo paradigm, also the electrophysiological effects of BZY were potentiated in slices from animals that had undergone cocaine and heroin selfadministration. Furthermore, BZY-induced LTD-like responses in the PLCx-NAcc circuitry were significantly reduced in the presence of the CB1 receptor antagonist AM251. These findings provide firm evidence of the abuse liability of BZY and suggest a possible cannabinoidergic mechanism of action. Further research is needed in order to give insights into the molecular mechanism underlying BZY psychoactive and reinforcing effects, to better understand its abuse potential.3

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Ingestions of benzydamine-containing vaginal preparations

Abstract: This is the largest report of benzydamine ingestions. The outstanding feature was the high percentage of neurological manifestations in children and adults, mainly hallucinations, following the ingestion of an over-the-counter product.

Cited by 12 publications

References 15 publications

Acute Psychotic Symptoms due to Benzydamine Hydrochloride Abuse with Alcohol

Acute Psychotic Symptoms due to Benzydamine Hydrochloride Abuse with Alcohol

Antibacterial Activity of Benzydamine Hydrochloride against Clinical Isolates of Bacteria, isolated from people in Russia and Spain

Intravenous self‐administration of benzydamine, a non‐steroidal anti‐inflammatory drug with a central cannabinoidergic mechanism of action

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