Ingestion of a natural mineral-rich water in an animal model of metabolic syndrome: effects in insulin signalling and endoplasmic reticulum stress

Pereira, Cidália; Passos, Emanuel; Severo, Mílton; Vito, I.; Wen, Xiao-Gang; Carneiro, Fátima; Gomes, Pedro; Monteiro, Rosário; Martins, Maria João

doi:10.1515/hmbci-2015-0033

Cited by 7 publications

(8 citation statements)

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“…Sirt1 has a role in glucocorticoid signaling. The disruption of endoplasmic reticulum homeostasis and impaired redox status can cause insulin resistance, which associates with hypertension [13,57,97,151,152,153]. Furthermore, El-Seweidy et al disclosed that the ingestion of a chloride-, sodium- and sulphate-rich as well as sulphurous, calcic and fluorurate mineral-rich water, for 7 weeks, improved glucose homeostasis in rats with streptozotocin-induced diabetes [74].…”

Section: Discussionmentioning

confidence: 99%

“…Although the etiology of MetSyn is still not entirely clear, it is known to involve complex interactions between genetic, metabolic and environmental factors [1,2,3,4,5,6,7,8,9]. Insulin resistance, altered redox state, endoplasmic reticulum stress, low grade pro-inflammatory state, hypercoagulable/prothrombotic state and endothelial dysfunction are also characteristics of the MetSyn [5,9,10,11,12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Syndrome Features: Is There a Modulation Role by Mineral Water Consumption? A Review

2019

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Metabolic syndrome (MetSyn) promotes, among others, the development of atherosclerotic cardiovascular disease and diabetes. Its prevalence increases with age, highlighting the relevance of promoting precocious MetSyn primary prevention and treatment with easy-to-implement lifestyle interventions. MetSyn features modulation through mineral water consumption was reviewed on Pubmed, Scopus and Google Scholar databases, using the following keywords: metabolic syndrome, hypertension, blood pressure (BP), cholesterol, triglycerides, apolipoprotein, chylomicron, very low-density lipoprotein, low-density lipoprotein, high-density lipoprotein (HDL), glucose, insulin, body weight, body mass index, waist circumference (WC), obesity and mineral(-rich) water. Twenty studies were selected: 12 evaluated BP, 13 assessed total-triglycerides and/or HDL-cholesterol, 10 analysed glucose and/or 3 measured WC. Mineral waters were tested in diverse protocols regarding type and composition of water, amount consumed, diet and type and duration of the study. Human and animal studies were performed in populations with different sizes and characteristics. Distinct sets of five studies showed beneficial effects upon BP, total-triglycerides, HDL-cholesterol and glucose. WC modulation was not reported. Minerals/elements and active ions/molecules present in mineral waters (and their pH) are crucial to counterbalance their inadequate intake and body status as well as metabolic dysfunction and increased diet-induced acid-load observed in MetSyn. Study characteristics and molecular/physiologic mechanisms that could explain the different effects observed are discussed. Further studies are warranted for determining the mechanisms involved in the putative protective action of mineral water consumption against MetSyn features.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome Features: Is There a Modulation Role by Mineral Water Consumption? A Review

2019

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“…The expression of both proteins was significantly higher in liver tissue of rats receiving mineral water compared to rats receiving tap water [ 49 ]. In addition, the amount of phosphorylated insulin receptor substrate (IRS), the active form of the substrate that forwards the insulin signal, was elevated in liver tissues of rats receiving mineral water compared with rats receiving tap water [ 50 ]. This indicates increased insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Prevention and Therapy of Type 2 Diabetes—What Is the Potential of Daily Water Intake and Its Mineral Nutrients?

et al. 2017

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We aim to present an overview of the possible influence of drinking water in general and mineral water in particular in improving glycemic parameters in persons with or without type 2 diabetes. We performed a literature search that produced 15 randomized controlled trials (RCTs) on this topic with mainly small sample sizes. We also discuss relevant observational and animal studies as well as the effects of important supplements in mineral water such as hydrogencarbonate and magnesium. There is low evidence for the positive effects of water or mineral water in improving glycemic parameters in diabetic and non-diabetic persons, and the results are heterogenous, making it difficult to reach an unequivocal conclusion. Meta-analyses of prospective cohort studies and other observational studies, studies with animal models and interventional studies using hydrogencarbonate and magnesium supplements suggest a probable positive effect of drinking water and mineral water in particular on glycemic parameters, supporting the positive results found in some of the RCTs, especially those substituting diet beverages or caloric beverages with water, or those using bicarbonate and magnesium-rich water. Regarding the high prevalence, the associated suffering and the resulting health expenditures of type 2 diabetes, it is imperative to conduct larger and more rigorous trials to answer the question whether drinking water or mineral water can improve glycemic parameters in diabetic and non-diabetic persons.

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“…The expression of both proteins was significantly higher in liver tissue of rats receiving mineral water compared to rats receiving tap water [35]. Besides, the amount of phosphorylated insulin receptor substrate (IRS), the active form of the substrate that forwards the insulin signal, was elevated in liver tissues of rats receiving mineral water compared with rats receiving tap water [36]. This indicates increased insulin sensitivity.…”

Section: Effect Of Mineral Rich Water In An Animal Modelmentioning

confidence: 98%

Preventing Diabetes—What Is the Potential of Daily Water Intake and Its Mineral Nutrients?

Naumann¹,

Biehler²,

Lüty³

et al. 2017

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To address the question whether there is evidence that drinking water in general or mineral water in particular is effective in preventing diabetes; we performed a literature search of randomized controlled trials (PubMed). The search resulted in very few trials (N = 9) investigating this topic: one trial investigates the effect of increasing water consumption on glycemic control in diabetic patients; two trials investigate the effect of drinking water with a meal in diabetic patients; while six trials compare the effect of mineral rich water with that of low mineralized water on glucose metabolism in healthy subjects. There is evidence that increasing water consumption can improve glucose metabolism and randomized controlled trials with mineral water suggest that waters containing relevant amounts of magnesium can exert an additional effect. The role of bicarbonate; which is present in all the mineral waters used in the trials; will be discussed. Future research needs to investigate the effect of mineral water in prediabetic individuals or individuals with impaired glycemic control.

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Ingestion of a natural mineral-rich water in an animal model of metabolic syndrome: effects in insulin signalling and endoplasmic reticulum stress

Cited by 7 publications

References 74 publications

Metabolic Syndrome Features: Is There a Modulation Role by Mineral Water Consumption? A Review

Metabolic Syndrome Features: Is There a Modulation Role by Mineral Water Consumption? A Review

Prevention and Therapy of Type 2 Diabetes—What Is the Potential of Daily Water Intake and Its Mineral Nutrients?

Preventing Diabetes—What Is the Potential of Daily Water Intake and Its Mineral Nutrients?

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Ingestion of a natural mineral-rich water in an animal model of metabolic syndrome: effects in insulin signalling and endoplasmic reticulum stress

Cited by 7 publications

References 74 publications

Metabolic Syndrome Features: Is There a Modulation Role by Mineral Water Consumption? A Review

Metabolic Syndrome Features: Is There a Modulation Role by Mineral Water Consumption? A Review

Prevention and Therapy of Type 2 Diabetes—What Is the Potential of Daily Water Intake and Its Mineral Nutrients?

Preventing Diabetes&mdash;What Is the Potential of Daily Water Intake and Its Mineral Nutrients?

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Preventing Diabetes—What Is the Potential of Daily Water Intake and Its Mineral Nutrients?