Ingestion and Excretion of Aluminum in Foods and Pharmaceuticals.

Matsushima, Fumiko; Meshitsuka, Shunsuke

doi:10.1265/jjh.56.528

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…The dietary intake of aluminum is 5 to 10 mg/ day. 21,22) The daily intake of water is about 2 liters and the amount of aluminum in drinking water is only 10% or less, compared with a total dietary intake of aluminum. It is unlikely that aluminum in drinking water is a risk factor of the Alzheimer's disease based on this value alone.…”

Section: Chemical Species and Daily Intake Of Aluminummentioning

confidence: 99%

A Risk of Alzheimer's Disease and Aluminum in Drinking Water

2002

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The epidemiological studies on the relation between Alzheimer's disease and aluminum in drinking water are reviewed. In descriptive studies, case-control studies, and also cohort studies aluminum in drinking water turned out to be positive for the senile dementia of Alzheimer type. Negative results were obtained in the studies of presenile dementia or alminum levels lower than 0.1 mg/L. Aluminum is the third abundant element on earth, therefore, exposure to aluminum is inevitable in daily life. It is known that as over 95% of cases with Alzheimer's disease are sporadic, some environmental factors are expected to be etiological. Aluminum has been so far studied as a candidate for a neurotoxic factor. It is not known why attention has been given to only aluminum in drinking water as the cause of the neuro-degenerative disease other than aluminum in foods or medications, and how aluminum acts as a toxicant in brain. Nonetheless, reduction of aluminum in drinking water is recommended, as well as investigations on the mechanism of neurotoxicity of aluminum to find out the way to be free from the fear of aluminum.

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Section: Chemical Species and Daily Intake Of Aluminummentioning

confidence: 99%

A Risk of Alzheimer's Disease and Aluminum in Drinking Water

2002

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“…The existence of this pollutant in nature and its various sources make exposure to this metal inevitable in human life (Unniram Parambil et al, 2022). For the general population, the main route of Al exposure is oral, since this metal is consumed through drinking water, freshly prepared natural sources (fresh fruits, vegetables, and meat), commercially processed foods and in infant formulas (Kazi et al, 2009; Matsushima & Meshitsuka, 2001). In addition, this metal is also found in packaging, antacids, vaccines, antiperspirants, kidney dialysis, parenteral nutrition, and cosmetics (Darbre et al, 2011; de Oliveira et al, 2010; El‐Sayed et al, 2011; Shaw et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia

Gomes

Lima

Costa

et al. 2023

Cell Biology International

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Several pollutants can alter neonatal prostatic development predisposing this gland to diseases. The toxicity and endocrine disrupting potential of aluminum has been reported in many organs, but little is known about its effects on the prostate. This study aimed to evaluate the effects that aluminum neonatal exposure can cause in the male ventral prostate and in the female prostate of adult and senile gerbils. Male and female pups were treated orally with aluminum chloride (10 mg/kg) from the 1st to the 14th day life. After treatment, the animals were aged until they reached 90 days or 1 year of life. The prostate glands were dissected out and submitted to morphological, immunohistochemical and ultrastructural analyses. Ventral prostates of adult males showed moderate hyperplasia and increased epithelial proliferation not associated with androgen receptor (AR) deregulation. On the other hand, senile males showed intense prostatic hyperplasia, and increased cell proliferation and epithelial AR regulation. Additionally, at both ages, there was a reduction in the prostate secretory function. The morphological changes observed in the female prostate were like those found in males. However, in adult females, prostatic hyperplasia was accompanied by a lower regulation of AR and estrogen receptor alpha, while in senile females, intense hyperplastic growth was associated with an increase in estrogen receptor alpha and a reduction in stromal AR. These results demonstrate that aluminum chloride neonatal exposure alters the hormonal regulation of the male and female prostate, inducing tissue damage that occurs in adulthood and intensifies during aging.

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