Ingested Maple Syrup Evokes a Possible Liver-Protecting Effect—Physiologic and Genomic Investigations with Rats

Abstract

Rats fed a 20%-maple syrup diet (maple syrup group) for 11 d showed significantly lower values of the hepatic function markers than those fed a 20%-sugar mix syrup diet (control). The reason was suggested by a DNA microarray analysis which revealed that the expression of genes for the enzymes of ammonia formation were down-regulated in the liver of the maple syrup group.

Development and UFLC-MS/MS Characterization of a Product-Specific Standard for Phenolic Quantification of Maple-Derived Foods

“…To date, maple-derived foods are being quantified for phenolic contents based on the widely used industrial standard, namely, gallic acid equivalents (GAEs), by the Folin-Ciocalteu assay (further discussed below). 6, 7, 11, 15, 17, 19 In addition, to date, there are no chemically characterized product-specific standard/s available for the authentication of maple products.…”

Administration of a maple syrup extract to mitigate their hepatic inflammation induced by a high-fat diet: a transcriptome analysis

“…We have shown that maple syrup has a significant liver-ameliorating function in male Wistar rats. 1) In detail, rats have been fed a modified AIN93G diet in which sucrose powder (10%) and β-cornstarch (10%) are substituted with sucrose solution (20%) as a control and also fed maple syrup instead of the sucrose solution for comparison. Our conclusion is that the maple syrup diet compared with the standard diet can significantly reduce the levels of the serum-organ impairment markers AST and LDH.…”

“…This may be the first report that have shown a health benefit of maple syrup found to confer a liver-protecting effect in animals. 1) Nagai et al 2) have reported that oral administration of maple sugar results in lowering plasma glucose levels in 30-and 60-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Apostolidis et al 3) showed that a butanol extract of maple syrup inhibits α-glucosidase in vitro, possibly by preventing elevation of plasma glucose levels in maple syrup-fed OLETF rats.…”

Metabolic activity of tree saps of different origin towards cultured human cells in the light of grade correspondence analysis and multiple regression modeling

“…Recent in vivo study in rats indicated that maple syrup may improve liver function through downregulation of genes involved in ammonia formation [30]. Yoo and colleagues demonstrated that sap obtained from Acer pictum Thunb.…”