Ingested manganese chloride as a contrast agent for magnetic resonance imaging

Cory, David A.; Schwartzentruber, Douglas J.; Mock, Bruce H.

doi:10.1016/0730-725x(87)90485-1

Cited by 64 publications

(44 citation statements)

References 14 publications

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“…Although research has established that diminished cardiac performance in heart failure is due to abnormal intracellular Ca 2þ handling, to the best of the authors' knowledge no technique exists to directly observe in vivo intracellular Ca 2þ efflux fluctuations across the plasma membrane (8,9 comparable to Ca 2þ . Mn 2þ also shortens the proton magnetization longitudinal relaxation time constant (T 1 ) during manganese-enhanced magnetic resonance imaging (MEMRI) (10,11). Furthermore, Mn 2þ enters the viable myocardial tissue via the Ltype voltage-gated Ca 2þ channels (12)(13)(14).…”

Section: Introductionmentioning

confidence: 98%

Assessing manganese efflux using SEA0400 and cardiac T₁‐mapping manganese‐enhanced MRI in a murine model

et al. 2009

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The sodium-calcium exchanger (NCX) is one of the transporters contributing to the control of intracellular calcium (Ca(2+)) concentration by normally mediating net Ca(2+) efflux. However, the reverse mode of the NCX can cause intracellular Ca(2+) concentration overload, which exacerbates the myocardial tissue injury resulting from ischemia. Although the NCX inhibitor SEA0400 has been shown to therapeutically reduce myocardial injury, no in vivo technique exists to monitor intracellular Ca(2+) fluctuations produced by this drug. Cardiac manganese-enhanced MRI (MEMRI) may indirectly assess Ca(2+) efflux by estimating changes in manganese (Mn(2+)) content in vivo, since Mn(2+) has been suggested as a surrogate marker for Ca(2+). This study used the MEMRI technique to examine the temporal features of cardiac Mn(2+) efflux by implementing a T(1)-mapping method and inhibiting the NCX with SEA0400. The change in (1)H(2)O longitudinal relaxation rate, Delta R(1), in the left ventricular free wall, was calculated at different time points following infusion of 190 nmol/g manganese chloride (MnCl(2)) in healthy adult male mice. The results showed 50% MEMRI signal attenuation at 3.4 +/- 0.6 h post-MnCl(2) infusion without drug intervention. Furthermore, treatment with 50 +/- 0.2 mg/kg of SEA0400 significantly reduced the rate of decrease in Delta R(1). At 4.9-5.9 h post-MnCl(2) infusion, the average Delta R(1) values for the two groups treated with SEA0400 were 2.46 +/- 0.29 and 1.72 +/- 0.24 s(-1) for 50 and 20 mg/kg doses, respectively, as compared to the value of 1.27 +/- 0.28 s(-1) for the control group. When this in vivo data were compared to ex vivo absolute manganese content data, the MEMRI T(1)-mapping technique was shown to effectively quantify Mn(2+) efflux rates in the myocardium. Therefore, combining an NCX inhibitor with MEMRI may be a useful technique for assessing Mn(2+) transport mechanisms and rates in vivo, which may reflect changes in Ca(2+) transport.

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Section: Introductionmentioning

confidence: 98%

Assessing manganese efflux using SEA0400 and cardiac T₁‐mapping manganese‐enhanced MRI in a murine model

et al. 2009

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“…A variety of natural contrast agents has been described as intraluminal contrast agents [15,16]. Moreover, there are biphasic contrast agents (positive in T1 weighted sequences and negative in T2 weighted sequences), and most of these are manganese-based (Mn) substances [13,17].…”

Section: Introductionmentioning

confidence: 99%

Use of pineapple juice with gadopentetate dimeglumine as a negative oral contrast for magnetic resonance cholangiopancreatography: a multicentric study

2011

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We evaluated the efficacy of pineapple juice with gadopentetate dimeglumine as a negative oral contrast agent for magnetic resonance cholangiopancreatography (MRCP). Images were obtained before and after the intake of a negative oral contrast agent. Images obtained from six different areas of the biliary tree were analyzed by three different radiologists, who were blind to the exams; scores regarding image quality were given to each area. The statistical analysis showed a significant difference between images before and after the use of the contrast agent (P < 0.001) for the three radiologists (R1-R3). Mean scores given by radiologists before the intake of the contrast agent were 2.49 ± 0.42 (R1), 2.62 ± 0.32 (R2), and 2.22 ± 0.46 (R3). After the intake, mean scores were 3.38 ± 0.62 (R1), 3.48 ± 0.55 (R2), and 2.89 ± 0.69 (R3). The ducts that showed the highest scores were the common bile duct and duct of Wirsung, the distal portion of the common bile duct and the cystic duct. We suggest herein that the contrast agent pineapple juice with gadopentate dimeglumine constitutes an efficient negative oral contrast agent for MRCP, for it efficiently eliminates the signal of the digestive tube in MRCP images.

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“…Mn 2+ has been used as a contrast agent in MRI as Mn 2+ is a calcium analogue and is also paramagnetic (Mendonca-Dias, Gaggelli et al 1983;Burnett, Goldstein et al 1984;Geraldes, Sherry et al 1986;Cory, Schwartzentruber et al 1987;Fornasiero, Bellen et al 1987). In MRI, Mn2+ enhancement has been effective for trans-synaptic neuronal tract tracing enabling the in vivo mapping of neuronal tracts (Pautler, Silva et al 1998;Pautler and Koretsky 2002;Saleem et al 2002;Pautler, Mongeau et al 2003;Chuang and Koretsky 2006).…”

Section: Introductionmentioning

confidence: 99%

In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease

et al. 2007

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Axonopathy is a pronounced attribute of many neurodegenerative diseases. In Alzheimer's Disease (AD), axonal swellings and degeneration are prevalent and may contribute to the symptoms of AD senile dementia. Current limitations in identifying the contribution of axonal damage to AD include the inability to detect when this damage occurs in relation to other identifiers of AD because of the invasiveness of existing methods. To overcome this, we further developed the MRI methodology Manganese Enhanced MRI (MEMRI) to assess in vivo axonal transport rates. Prior to amyloid-beta (Aβ) deposition, the axonal transport rates in the Tg2576 mouse model of AD were normal. As Aβlevels increased and before plaque formation, we observed a significant decrease in axonal transport rates of the Tg2576 mice compared to controls. After plaque formation, the decline in the transport rate in the Tg2576 mice became even more pronounced. These data indicate that in vivo axonal transport rates decrease prior to plaque formation in the Tg2576 mouse model of AD.

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Ingested manganese chloride as a contrast agent for magnetic resonance imaging

Cited by 64 publications

References 14 publications

Assessing manganese efflux using SEA0400 and cardiac T₁‐mapping manganese‐enhanced MRI in a murine model

Assessing manganese efflux using SEA0400 and cardiac T₁‐mapping manganese‐enhanced MRI in a murine model

Use of pineapple juice with gadopentetate dimeglumine as a negative oral contrast for magnetic resonance cholangiopancreatography: a multicentric study

In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease

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Ingested manganese chloride as a contrast agent for magnetic resonance imaging

Cited by 64 publications

References 14 publications

Assessing manganese efflux using SEA0400 and cardiac T1‐mapping manganese‐enhanced MRI in a murine model

Assessing manganese efflux using SEA0400 and cardiac T1‐mapping manganese‐enhanced MRI in a murine model

Use of pineapple juice with gadopentetate dimeglumine as a negative oral contrast for magnetic resonance cholangiopancreatography: a multicentric study

In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease

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Assessing manganese efflux using SEA0400 and cardiac T₁‐mapping manganese‐enhanced MRI in a murine model

Assessing manganese efflux using SEA0400 and cardiac T₁‐mapping manganese‐enhanced MRI in a murine model