Ingenious pH-sensitive etoposide loaded folic acid decorated mesoporous silica-carbon dot with carboxymethyl-βcyclodextrin gatekeeper for targeted drug delivery and imaging

Shirani, Marziyeh Poshteh; Rezaei, Behzad; Khayamian, Taghi; Dinari, Mohammad; Shamili, Fazileh Hosseini; Ramezani, Mohammad; Alibolandi, Mona

doi:10.1016/j.msec.2018.07.043

Cited by 28 publications

(11 citation statements)

References 51 publications

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“…Folate receptor is overexpressed in 4T1 cells, but rarely expressed in HepG2 cells, so 4T1 cells and HepG2 cells were selected for experiment [36,37,38,39]. Herein, cytotoxicity of FA-PEG-Pam/CaP/NDs and its reference formulations was evaluated on HepG2 and 4T1 cells by the MTT assay.…”

Section: Resultsmentioning

confidence: 99%

A Valid Bisphosphonate Modified Calcium Phosphate-Based Gene Delivery System: Increased Stability and Enhanced Transfection Efficiency In Vitro and In Vivo

Zhao

Chen

et al. 2019

Pharmaceutics

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Calcium phosphate (CaP) nanoparticles, as a promising vehicle for gene delivery, have been widely used owing to their biocompatibility, biodegradability and adsorptive capacity for nucleic acids. Unfortunately, their utility in vivo has been profoundly restricted due to numerous technical barriers such as the lack of tissue specificity and limited transfection efficiency, as well as uncontrollable aggregation over time. To address these issues, an effective conjugate folate-polyethylene glycol-pamidronate (shortened as FA-PEG-Pam) was designed and coated on the surface of CaP/NLS/pDNA (CaP/NDs), forming a versatile gene carrier FA-PEG-Pam/CaP/NDs. Inclusion of FA-PEG-Pam significantly reduced the size of CaP nanoparticles, thus inhibiting the aggregation of CaP nanoparticles. FA-PEG-Pam/CaP/NDs showed better cellular uptake than mPEG-Pam/CaP/NDs, which could be attributed to the high-affinity interactions between FA and highly expressed FR. Meanwhile, FA-PEG-Pam/CaP/NDs had low cytotoxicity and desired effect on inducing apoptosis (71.1%). Furthermore, FA-PEG-Pam/CaP/NDs showed admirable transfection efficiency (63.5%) due to the presence of NLS peptides. What’s more, in vivo studies revealed that the hybrid nanoparticles had supreme antitumor activity (IR% = 58.7%) among the whole preparations. Altogether, FA-PEG-Pam/CaP/NDs was expected to be a hopeful strategy for gene delivery.

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Section: Resultsmentioning

confidence: 99%

A Valid Bisphosphonate Modified Calcium Phosphate-Based Gene Delivery System: Increased Stability and Enhanced Transfection Efficiency In Vitro and In Vivo

Zhao

Chen

et al. 2019

Pharmaceutics

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“…Applying NaBH 4 as reductive agent led to the formation of nanoparticles in a range of 2–4 nm, its particles smaller than the unmodified MIL-100 (>20 nm). MOF was synthesized by linking 4-carboxy-phenylacetylene (PA) species to form an organometallic bond with Au(I) . The linking PA to hydroxo, oxo 8-fold hexa-zirconium(IV)-aqua nodes of NU-1000 was carried out by solvent-assisted ligand installation (SALI) incorporation.…”

Section: Synthesismentioning

confidence: 99%

MOFs as Versatile Catalysts: Synthesis Strategies and Applications in Value-Added Compound Production

et al. 2023

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Catalysts played a crucial role in advancing modern human civilization, from ancient times to the industrial revolution. Due to high cost and limited availability of traditional catalysts, there is a need to develop cost-effective, high-activity, and nonprecious metal-based electrocatalysts. Metal−organic frameworks (MOFs) have emerged as an ideal candidate for heterogeneous catalysis due to their physicochemical properties, hybrid inorganic/organic structures, uncoordinated metal sites, and accessible organic sections. MOFs are high nanoporous crystalline materials that can be used as catalysts to facilitate polymerization reactions. Their chemical and structural diversity make them effective for various reactions compared to traditional catalysts. MOFs have been applied in gas storage and separation, ion-exchange, drug delivery, luminescence, sensing, nanofilters, water purification, and catalysis. The review focuses on MOF-enabled heterogeneous catalysis for value-added compound production, including alcohol oxidation, olefin oligomerization, and polymerization reactions. MOFs offer tunable porosity, high spatial density, and single-crystal XRD control over catalyst properties. In this review, MOFs were focused on reactions of CO 2 fixation, CO 2 reduction, and photoelectrochemical water splitting. Overall, MOFs have great potential as versatile catalysts for diverse applications in the future.

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“…Therefore, these interactions are a powerful tool for engineering nanomaterials as “gatekeepers,” which can modulate controlled drug delivery. For example, Shirani et al [ 252 ] created a nanocarrier for drug delivery and bioimaging. The nanocarrier traits are conferred by the mesoporous silica and luminescent CDs [ 252 ].…”

Section: Carbon Dot–silica Nanoparticle Synthesis and Applicationsmentioning

confidence: 99%

“…For example, Shirani et al [ 252 ] created a nanocarrier for drug delivery and bioimaging. The nanocarrier traits are conferred by the mesoporous silica and luminescent CDs [ 252 ]. In brief, the synthesis was performed by using the pyrolysis route to obtain CDs from glucose and L-aspartic acid.…”

Section: Carbon Dot–silica Nanoparticle Synthesis and Applicationsmentioning

confidence: 99%

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A Brief Review of Carbon Dots–Silica Nanoparticles Synthesis and their Potential Use as Biosensing and Theragnostic Applications

Ornelas-Hernández¹,

Garduno-Robles²,

Zepeda‐Moreno

2022

Nanoscale Res Lett

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Carbon dots (CDs) are carbon nanoparticles with sizes below 10 nm and have attracted attention due to their relatively low toxicity, great biocompatibility, water solubility, facile synthesis, and exceptional photoluminescence properties. Accordingly, CDs have been widely exploited in different sensing and biomedical applications, for example, metal sensing, catalysis, biosensing, bioimaging, drug and gene delivery, and theragnostic applications. Similarly, the well-known properties of silica, such as facile surface functionalization, good biocompatibility, high surface area, and tunable pore volume, have allowed the loading of diverse inorganic and organic moieties and nanoparticles, creating complex hybrid nanostructures that exploit distinct properties (optical, magnetic, metallic, mesoporous, etc.) for sensing, biosensing, bioimaging, diagnosis, and gene and drug delivery. In this context, CDs have been successfully grafted into diverse silica nanostructures through various synthesis methods (e.g., solgel chemistry, inverse microemulsion, surfactant templating, and molecular imprinting technology (MIT)), imparting hybrid nanostructures with multimodal properties for distinct objectives. This review discusses the recently employed synthesis methods for CDs and silica nanoparticles and their typical applications. Then, we focus on combined synthesis techniques of CD–silica nanostructures and their promising biosensing operations. Finally, we overview the most recent potential applications of these materials as innovative smart hybrid nanocarriers and theragnostic agents for the nanomedical field. Graphical abstract

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Ingenious pH-sensitive etoposide loaded folic acid decorated mesoporous silica-carbon dot with carboxymethyl-βcyclodextrin gatekeeper for targeted drug delivery and imaging

Cited by 28 publications

References 51 publications

A Valid Bisphosphonate Modified Calcium Phosphate-Based Gene Delivery System: Increased Stability and Enhanced Transfection Efficiency In Vitro and In Vivo

A Valid Bisphosphonate Modified Calcium Phosphate-Based Gene Delivery System: Increased Stability and Enhanced Transfection Efficiency In Vitro and In Vivo

MOFs as Versatile Catalysts: Synthesis Strategies and Applications in Value-Added Compound Production

A Brief Review of Carbon Dots–Silica Nanoparticles Synthesis and their Potential Use as Biosensing and Theragnostic Applications

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