Infusion of docosahexaenoic acid protects against myocardial infarction

Richard, Daniel; Oszust, Floriane; Guillaume, Christine; Millart, Hervé; Laurent-Maquin, Dominique; Brou, Christel; Bausero, Pedro; Visioli, Francesco

doi:10.1016/j.plefa.2014.01.001

Cited by 25 publications

(14 citation statements)

References 21 publications

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“…Indeed, several reports have recently yielded beneficial effects of Omega-3. Thus, the administration of DHA before IR and/or before/after induction of IR in perfused isolated heart protects from ischemic damage (34). Similarly, two intraperitoneal injections of Omega-3 emulsion performed just after reperfusion and 60 min.…”

Section: Discussionmentioning

confidence: 98%

An Intravenous Bolus of Epa

Burban

Meyer

Olland

et al. 2016

Shock

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Section: Discussionmentioning

confidence: 98%

An Intravenous Bolus of Epa

Burban

Meyer

Olland

et al. 2016

Shock

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“…19 Other investigations also reported that DHA suppressed arrhythmia induced by ischemia, inhibited thromboxanelike vasoconstrictor responses, and curtailed hypertension in spontaneously hypertensive rats, 20 but the mechanism remains speculative. Some groups report that DHA and EPA can be beneficial for the mitochondria by enhancing the resistance to mitochondrial permeability transition.…”

Section: Discussionmentioning

confidence: 99%

Resolvin D1 Reduces Infarct Size Through a Phosphoinositide 3-Kinase/Protein Kinase B Mechanism

Kim

Bernier

Bourque-Riel

et al. 2015

Journal of Cardiovascular Pharmacology

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This study was designed to determine if Resolvin D1 (RvD1), a pro-resolution metabolite of the omega-3 polyunsaturated fatty acid docosahexaenoic acid, could decrease myocardial infarct size with delivered at the onset of ischemia. Male Sprague Dawley rats underwent 40 minutes of myocardial ischemia followed by reperfusion. These animals received 1 intraventricular injection of RvD1 (0.01, 0.1, or 0.3 μg RvD1) or vehicle (saline) before coronary occlusion. Infarct size and neutrophil accumulation were evaluated 24 hours after the onset of reperfusion. Caspase-3, caspase-8, protein kinase B (Akt) activities were evaluated 30 minutes after the reperfusion. Rats receiving 0.1 or 0.3 μg RvD1 showed a significant decrease of infarct size and caspase-3 and caspase-8 activities compared with the vehicle controls. Neutrophil accumulations were reduced in rats administered RvD1 compared with vehicle, independently of dose level. Akt activation was increased only in animals receiving 0.1 or 0.3 μg, whereas no change was observed in the 0.01 μg group. When they were treated with LY-294002, a phosphoinositide 3-kinase (PI3K)/Akt inhibitor, cardioprotection by RvD1 was abrogated. RvD1 treatment at the onset of ischemia decreases infarct size by a mechanism involving the PI3K/Akt pathway.

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“…Of the commonly used natural health products consumed regularly, omega-3 fatty acid, coenzyme Q10, ginseng products, resveratrol and other polyphenols appear to have most notable cardiovascular protective properties [50][51][52][53][54][55][56][57]. These products may act either directly or indirectly to enhance the protective effect of adenosine and ATP by moderating their uptake and/or metabolism.…”

Section: Natural Health Products For Cardioprotectionmentioning

confidence: 99%