Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study

Kofi, Boniface; Mossoro-Kpinde, Christian Diamant; Bouassa, Ralph-Sydney Mboumba; Péré, Hélène; Robin, Leman; Grésenguet, Gérard; Bélec, Laurent

doi:10.1186/s13027-019-0225-x

Cited by 9 publications

(9 citation statements)

References 13 publications

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“…This is more or less the same observation that has been made in some African countries. For example, HPV was found in 6.3% of HNC cases in a study in South Africa; [24] 0.74% in Central Africa for Kofi et al [25]; and like our case, it could not be detected in studies in Mozambique [26] and Nigeria [27]. These results are different from what has been reported in other parts of the world.…”

Section: Discussioncontrasting

confidence: 86%

Study of Epidemiology and Human Papilloma Virus Prevalence in Oral Cavity Cancers

2021

Mol Genet Res Open

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Oral cavity cancers (OCC) are the most common malignancies in the subcategory of head and neck cancers, and represent the 6th most common cancer in the world. These cancers have become more frequent in individuals without a history of alcohol-tobacco abuse, which are the major risk factors. Other factors have been suggested, such as viral infections, but especially genetic alterations. This work establishes the epidemiological profile and researches the presence of viral DNA in OCCs. The epidemiology was highlighted with 105 patients using the Epi Info software. HPV DNA was sought in 50 samples of diseased tissue and blood by attempting to amplify its L1 region by PCR. At the epidemiological level, the results show a mean age of 53.2 years, a sex ratio of 0.8 and a low consumption of tobacco (16.2%) and alcohol (4.8%). HPV was not detected in any of the samples. Thus, the epidemiological profile of OCCs in Senegal is different from that in other countries, and HPV is not associated with its occurrence.

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Section: Discussioncontrasting

confidence: 86%

Study of Epidemiology and Human Papilloma Virus Prevalence in Oral Cavity Cancers

2021

Mol Genet Res Open

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“…Similarly, no HPV DNA was detected in 51 FFPE samples from oral tongue and oropharynx squamous cell carcinomas tested using HPV16 specific PCR for the oncogenes E6 and E7 and p16 immunostaining in Mozambique . In a recent study from the Central African Republic, HPV16 was detected in only one of 135 HNSCCs screened for HPV …”

Section: Discussionmentioning

confidence: 98%

“…23 In a recent study from the Central African Republic, HPV16 was detected in only one of 135 HNSCCs screened for HPV. 24 The few other reports from South Africa have had small patient numbers and conflicting results. 8 HPV DNA has previously been largely detected in carcinomas of the oropharynx.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus DNA in head and neck squamous cell carcinomas in the Free State, South Africa

Bulane

Goedhals

Seedat

et al. 2019

Journal of Medical Virology

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Human papillomaviruses (HPVs) have been associated with a subset of head and neck squamous cell carcinomas (HNSCCs). The aim of this study was to determine the prevalence of HPV DNA in archived formalin‐fixed paraffin‐embedded tissue from patients with histologically confirmed HNSCCs in a South African cohort. A nested PCR was used for the detection of HPV DNA targeting the L1 gene. Positive samples were confirmed using an in‐house hemi‐nested PCR targeting the E6 gene and genotyped by sequence determination of amplicons. HPV DNA was detected in 57/780 (7.3%) samples, with the highest prevalence being in the sinonasal tract (16.0%) and oropharynx (10.8%). HPV16 was the most frequently detected type, being found in 26/57 (45.6%) positive samples. The prevalence of HPV DNA in HNSCCs found in this study was lower than that found in developed countries

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“…There are few studies from Africa, and Nigeria in particular on the role of Human papilloma virus in OPC. In a retrospective study in the Central African Republic [ 11 ] where 135 head and neck cancer specimens from 2009-2017 were reviewed, the prevalence of HPV in head and neck cancer was found to be 0.74%. This low value was attributed to their storage protocol and the fact that their specimens were only from the oral cavity and the larynx.…”

Section: Discussionmentioning

confidence: 99%

Characterization of high risk human papilloma virus (HPV) genotypes associated with oropharyngeal cancers in a Nigerian population

Akhiwu¹,

Akhiwu²,

Afolaranmi³

et al. 2021

Pan Afr Med J

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Introduction head and neck cancers have essentially been a disease of the elderly but recent studies are beginning to demonstrate their increasing incidence in young people with infections such as human papilloma virus (HPV). This study was carried out to determine the prevalence of high risk Human papilloma virus (hrHPV) related oropharyngeal carcinoma and its prevalent genotypes as well as their strength of association with HIV in adult Nigerian subjects. Methods this was a cross-sectional study of 41 patients with oropharyngeal carcinomas seen over a 2-year period. Patients had incisional and/or excisional biopsy done under anesthesia. A portion of the specimen from which the DNA was extracted was placed in Digene HC2 DNA collection device while the 2 nd portion for histopathological analysis was fixed using 10% Neutral Buffered Formalin (NBF) and embedded in paraffin blocks. Oropharyngeal cancer HPV genotyping was done using HPV genotypes 14 real-tm quant kit (SACACE, Italy). The data was analyzed using SPSS version 23. Results prevalence of HPV was 17.1% with a male to female ratio of 2.7: 1. The identified genotypes were 16, 33, 35 and 52 with 28.6% of patients having more than one genotype. Most of the age groups studied were affected. Squamous cell carcinoma and ameloblastic carcinoma were the cancers associated with HPV. HPV was not identified in the HIV positive patients. Conclusion high-risk human papilloma virus genotypes 16, 33, 35 and 52 are associated with oropharyngeal carcinoma in Nigeria but were not found in HIV patients. This finding provides a strong evidence for the use of the 9-valent prophylactic vaccine for the prevention of oropharyngeal cancer in Nigeria. Public awareness and HPV prevention strategies should reduce significantly the incidence of oropharyngeal carcinomas in our environment.

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Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study

Cited by 9 publications

References 13 publications

Study of Epidemiology and Human Papilloma Virus Prevalence in Oral Cavity Cancers

Study of Epidemiology and Human Papilloma Virus Prevalence in Oral Cavity Cancers

Human papillomavirus DNA in head and neck squamous cell carcinomas in the Free State, South Africa

Characterization of high risk human papilloma virus (HPV) genotypes associated with oropharyngeal cancers in a Nigerian population

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