Human papillomavirus DNA in head and neck squamous cell carcinomas in the Free State, South Africa

Bulane, Atang; Goedhals, Dominique; Seedat, Riaz Y.; Goedhals, Jacqueline; Burt, Felicity J.

doi:10.1002/jmv.25556

Cited by 18 publications

(19 citation statements)

References 25 publications

(70 reference statements)

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“…South African studies on HPV prevalence in the mouth and oropharynx are limited to 14. Of these, only 2 were conducted from oral rinse and gargle samples [22,23], 6 used oral brushes to collect samples [18,20,[32][33][34][35], and 6 were performed on formalin-fixed paraffin-embedded SCC samples [19,21,[36][37][38][39]. is highlights the importance for data on HPV infection in the head and neck region of South Africans.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Prevalence in Oral and Oropharyngeal Rinse and Gargle Specimens of Dental Patients and of an HIV-Positive Cohort from Pretoria, South Africa

Wood

Makua

Lebelo

et al. 2020

Advances in Virology

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Introduction. Studies on HPV prevalence in the head and neck region of South Africans are sparse. Of the available reports in the literature, there were no studies on the association between HPV-DNA presence in the mouth and oropharynx in relation to high-risk behaviours such as oral sex practice or tobacco and alcohol use. Materials and Methods. Following ethical clearance and informed consent, patients attending a regional HIV-management clinic and patients attending a dental hospital were recruited to this study. The participants completed an interview-based questionnaire obtaining demographic information, data on HIV serostatus, and behavioural data including sexual practices and tobacco and alcohol use, and a rinse-and-gargle specimen was taken. Specimens were analysed for HPV DNA on 3 separate PCR/qPCR platforms. Statistical analyses were performed for associations between the study group and categorical variables, HPV status, and data from the questionnaires. Results. Of 221 participants, 149 were from a general population and 72 from the HIV-management clinic. Smokers comprised 29.4% of the sample, and 45.2% of participants reported to have ever used alcohol. Open mouth kissing during teenage years was confirmed by 64.7% of participants, 40.3% have given oral sex with their mouth, and 44.8% confirmed to have received oral sex from their partner’s mouth. Seven participants (3.2%) had detectable α-HPV DNA, and 1 (0.4%) had detectable β-HPV DNA in their rinse-and-gargle specimens. Two participants were from the HIV-management clinic and 6 from the general dental population (overall 3.6%). Conclusion. Five high-risk HPV, 2 low-risk HPV, and one β-HPV types were detected. The low prevalence of 3.6% compares well to similar studies in different cohorts studied in South Africa and falls within the global oral/oropharyngeal prevalence spectrum. Only 4 participants, all from the HIV-management clinic, had palatine tonsils. No significant relationships were found between HPV presence and demographic data or sexual, oral sexual, tobacco use, or alcohol use, and no associations were seen with numbers of sexual and oral-sex partners.

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Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Prevalence in Oral and Oropharyngeal Rinse and Gargle Specimens of Dental Patients and of an HIV-Positive Cohort from Pretoria, South Africa

Wood

Makua

Lebelo

et al. 2020

Advances in Virology

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“…The findings of this study contribute knowledge regarding HPV18 isolates associated with HNSCCs ( 10 , 11 ) and lay the groundwork for future research into HPV-associated HNSCC genomic characterization in South Africa.…”

Section: Announcementmentioning

confidence: 68%

Whole-Genome Sequence and Comparative Analysis of Human Papillomavirus Type 18 Isolated from a Nasopharyngeal Carcinoma from South Africa

Munsamy

Seedat

Sekee

et al. 2021

Microbiol Resour Announc

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Section: Resultsmentioning

confidence: 96%

“…15 Likewise, a study of the South-African cohort found HPV DNA in 57/780 (7.3%) samples, with the highest prevalence being in the sinonasal tract (16.0%) and oropharynx (10.8%). 16 HPV16 was the most commonly detected type, being found in 26/57 (45.6%) positive samples. 16 The Human Papillomavirus (HPV) Known for its ability to infect and replicate in epithelial cells in the skin and mucosal regions, HPVs constitute a large family of non-enveloped double-stranded DNA viruses, with over 220 types having been identified.…”

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confidence: 96%

Human Papillomavirus-Associated Head and Neck Cancers. Where are We Now? A Systematic Review

Pinkiewicz¹,

Dorobisz²,

Zatoński³

2022

CMAR

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Background Human papillomavirus targets the skin and mucous membranes, producing benign hyperplastic lesions and precancerous and cancerous lesions. An increasing number of head and neck cancersin particular, oropharyngeal squamous cell carcinoma, laryngeal squamous cell carcinoma, and oral squamous cell carcinoma, are attributable to HPV infection. HPV-induced HNCs typically affect younger, nonsmoking patients with no prior history of heavy alcohol use, more extensive sexual history, and higher socioeconomic status. Aim The purpose of the review is to present the most recent and well-established findings concerning HPV-induced head and neck cancers and consequently to provide medical specialists with essential information regarding the epidemiology, the role of HPV in HNC cancerogenesis, prevention, diagnosis, and treatment. Material and Methods All authors independently have searched The EMbase, Medline/Pubmed, and Cochrane databases by using the following keywords “head and neck cancer”, “human papillomavirus”, “HPV”, “HPV biology”, “oropharyngeal squamous cell carcinoma”, “carcinogenesis”, “transoral surgery”, “robotic surgery”. The last search was conducted in March 2022. The references of the publications of interest were also screened for relevant papers. There were no limitations in regard to the publication date. Conclusion Aiming to avoid the epidemic of HPV-induced HNC, it is paramount to improve the access to vaccination as well as resolve parental concerns regarding vaccine safety. Physicians should rely on reduced-dose radiation and aim to reduce the overall treatment time. Thanks to a more elaborate understanding of the genomic background of HPV-induced HNC, precision medicine could become a relevant part of patients’ management. In comparison to traditional techniques and non-operative treatment, transoral robotic surgery (TORS) offers similar oncologic and functional outcomes, with a possible benefit on long-term quality of life. However, more research is needed to establish clear guidelines indicating when TORS resections should be supported with adjuvant therapy.

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Human papillomavirus DNA in head and neck squamous cell carcinomas in the Free State, South Africa

Cited by 18 publications

References 25 publications

Human Papillomavirus Prevalence in Oral and Oropharyngeal Rinse and Gargle Specimens of Dental Patients and of an HIV-Positive Cohort from Pretoria, South Africa

Human Papillomavirus Prevalence in Oral and Oropharyngeal Rinse and Gargle Specimens of Dental Patients and of an HIV-Positive Cohort from Pretoria, South Africa

Whole-Genome Sequence and Comparative Analysis of Human Papillomavirus Type 18 Isolated from a Nasopharyngeal Carcinoma from South Africa

Human Papillomavirus-Associated Head and Neck Cancers. Where are We Now? A Systematic Review

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