Infrequent Association of Epstein-Barr Virus with CD30-Positive Anaplastic Large Cell Lymphomas from American and Asian Patients

Epstein–Barr virus in CD30+ anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea

“…15 A low rate of immunoreactivity for EBV-associated LMP-1 has been reported in EBER-positive cases. 11 In our study, however, the results of EBER in situ hybridization were largely consistent with those of LMP-1 immunostaining. All EBV-positive cases demonstrated a considerable number of cells that were positive for both EBER in situ hybridization and LMP-1 immunostaining.…”

“…The frequency of EBV in T-cell tumors is reportedly higher in Asian populations than in Western populations. 17,18 In a study by Lopategui et al ., 11 the few cases of CD30 + ALCL positive for EBV were from Hong Kong, whereas only one of 20 American cases was associated with EBV. In Korea, a high incidence of EBV was observed in peripheral T-cell lymphoma, with a predilection for angiocentric lymphomas and extranodal presentations, especially involving the nose, skin, and gastrointestinal tract.…”

“…However, the majority do not support this association because EBV has not been found in either CD30 + ALCL or LyP. 2,[8][9][10][11][12][13] Therefore, the association of CD30 + lymphoproliferative disorders with EBV still remains unclear.…”

CD30-Positive Cutaneous Large Cell Lymphomas:A Comparative Study of Clinicopathologic and Molecular Features of 16 Cases

“…The detection of herpes viridae sequences by PCR technique may be due to the presence of EBV or CMV infected nontumoral cells. 40 These findings are in agreement with those of De Bruin and colleagues 16 and Lopategui and associates 41 who did not detect EBER sequences using ISH in tumoral cells of PCLCL. The one EBV-associated CD30-positive lymphoma differed by its clinical and phenotypic profiles.…”

Hodgkin disease with subsequent transformation to CD30 positive non-Hodgkin lymphoma in six patients

“…52,53 Similarly, EBER-1 positivity was seen in 13 of 19 of our patients with Hodgkin disease. Several previous studies 54,55 have indicated that ALCLs may occasionally express EBER-1.…”