Hodgkin disease with subsequent transformation to CD30 positive non-Hodgkin lymphoma in six patients

Mori, Naoyoshi; Watanabe, Kazuko; Yamashita, Yoshihisa; Nakayama, Atsuo; Yatabe, Yasushi; Narita, Masahiko; Kobayashi, Tetsuhiko; Hasegawa, Yuuichi; Kojima, Hiroshi; Nagasawa, Toshiro

doi:10.1002/(sici)1097-0142(19990215)85:4<970::aid-cncr27>3.0.co;2-l

Cited by 7 publications

(2 citation statements)

References 43 publications

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“…Studies have shown that patients with HL have an increased risk of developing second histologically unrelated malignancies 4. Non‐Hodgkin lymphoma (NHL) following treatment for HL has been reported with considerable variations in incidence 4, 5. However, vaginal involvement by NHL occurring subsequent to treatment for CHL is extremely rare, with only one case reported in the English literature 1.…”

Section: Discussionmentioning

confidence: 99%

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B‐cell lymphoma of the vagina occurring after treatment for classic Hodgkin lymphoma: A case report and literature review

Chen

Hamele‐Bena

Chow

et al. 2011

Diagnostic Cytopathology

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Section: Discussionmentioning

confidence: 99%

“…Second lymphoid malignant neoplasms occurring in patients treated for Hodgkin lymphoma (HL) are well documented 4–6. However, uterine involvement by DLBCL occurring after treatment for classic Hodgkin lymphoma (CHL) is extremely rare 1, 7.…”

mentioning

confidence: 99%

B‐cell lymphoma of the vagina occurring after treatment for classic Hodgkin lymphoma: A case report and literature review

Chen

Hamele‐Bena

Chow

et al. 2011

Diagnostic Cytopathology

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Blessing or curse? Proteomics in granzyme research

Joeckel

Bird

2014

Proteomics Clinical Apps

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Granzymes (gzms) are a group of serine proteases that play an important role in innate and adaptive immunity, blood coagulation, apoptosis, and inflammation, but are also connected to atherosclerosis, diabetes, cardiovascular and inflammatory lung diseases, cancer, and sepsis. Humans have five gzms (gzms A, B, H, K, and M), which differ in their substrate specificity. It is widely accepted that they are delivered from cytotoxic lymphocytes via perforin into the cytoplasm of target cells where they initiate cell death, modulate cytokine signaling, or inactivate pathogen proteins. However, more recent evidence indicates gzms also act extracellularly in noncytotoxic processes. Proteomic approaches are directed at mapping gzm cleavage specificity, identifying substrates, and unraveling the (patho-) physiological role of these proteases. These studies have refined our understanding of gzm species specificity, and collectively uncovered an enormous number of new substrates. However, with the exception of a very few human gzmB substrates supported by independent data (Bid, DNA-PK, PARP, ICAD, and procaspase 7), it is presently unclear which are physiologically relevant. This review aims to summarize and analyze the different proteomic approaches used and discuss both their convincing and controversial outcomes.

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Lymph nodes

2011

Rosai and Ackerman's Surgical Pathology

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Hodgkin disease with subsequent transformation to CD30 positive non-Hodgkin lymphoma in six patients

Cited by 7 publications

References 43 publications

B‐cell lymphoma of the vagina occurring after treatment for classic Hodgkin lymphoma: A case report and literature review

B‐cell lymphoma of the vagina occurring after treatment for classic Hodgkin lymphoma: A case report and literature review

Blessing or curse? Proteomics in granzyme research

Lymph nodes

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