Infrared spectroscopy in pharmacy

Kalinkova, G.N.

doi:10.1016/s0924-2031(99)00017-x

Cited by 28 publications

(10 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A logical way to estimate the biochemical behaviour is by the evaluation of the structural energies and dipole moment values in different solvent media. Recently, much attention has been paid to seek a correlation between the dipolar moments of compounds, in particular drugs, and their biological activities [21][22][23] which has simulated the search for such a correlation between electron density distribution in a molecule of a given compound and its activity [11]. In this section, we report a survey of biological stability as well as polarities of two considered ligands of GABA receptor in different solvents.…”

Section: Solvent Effects On the Structural Stability And Structural Pmentioning

confidence: 99%

DFT outlook of solvent effect on function of nano bioorganic drugs

Моллаамин

Monajjemi

2012

Physics and Chemistry of Liquids

View full text Add to dashboard Cite

The different physicochemical properties including energies as well as NQR parameters of -carboline and of its synthetic benzodiazepine receptor, N-ethyl-3-carbamoyl--carboline have been explained in terms of the optimised structure of the solvated molecules at the B3LYP/6-311þþG** level of theory within the Onsager self-consistent reaction field solvation model. Apart from most of the gas phase calculations published on -carbolines, in this work, we have included solvation effects in order to predict the relative physicochemical properties of these compounds. It often means that the gas phase calculations are insufficient and therefore the inclusion of these solvation effects is necessary. In order to gain insight into typical solvent-ligand interactions, their total and relative energies as well as dipole moments have been determined in different solvents of variable polarity. To analyse the electrostatic interactions of particular bioactive atoms in both considered ligands with different solvents, the 14 N-NQR parameters have been determined for individual nitrogen atoms of the compounds considered. Our finding leads us to wonder that the physiological function of the two considered ligands of GABA receptor involves alertness and other related attributes of any consistency embedded in solvation effects.

show abstract

Section: Solvent Effects On the Structural Stability And Structural Pmentioning

confidence: 99%

DFT outlook of solvent effect on function of nano bioorganic drugs

Моллаамин

Monajjemi

2012

Physics and Chemistry of Liquids

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, this is the first time that attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy has been used for the direct quantification of the drug-load of nanoparticles. FTIR spectroscopy is a well-established technique within the pharmaceutical industry with applications ranging from qualitative to quantitative analyses [ 32 , 33 , 34 , 35 , 36 , 37 ]. In the latter, its major advantage over UV-visible spectroscopy is that practically all compounds absorb IR light and can thus be analyzed.…”

Section: Introductionmentioning

confidence: 99%

Direct Quantification of Drug Loading Content in Polymeric Nanoparticles by Infrared Spectroscopy

et al. 2020

View full text Add to dashboard Cite

Nanotechnology has enabled the development of novel therapeutic strategies such as targeted nanodrug delivery systems, control and stimulus-responsive release mechanisms, and the production of theranostic agents. As a prerequisite for the use of nanoparticles as drug delivery systems, the amount of loaded drug must be precisely quantified, a task for which two approaches are currently used. However, both approaches suffer from the inefficiencies of drug extraction and of the solid-liquid separation process, as well as from dilution errors. This work describes a new, reliable, and simple method for direct drug quantification in polymeric nanoparticles using attenuated total reflection Fourier transform infrared spectroscopy, which can be adapted for a wide variety of drug delivery systems. Silk fibroin nanoparticles and naringenin were used as model polymeric nanoparticle carrier and drug, respectively. The specificity, linearity, detection limit, precision, and accuracy of the spectroscopic approach were determined in order to validate the method. A good linear relation was observed within 0.00 to 7.89% of naringenin relative mass with an R2 of 0.973. The accuracy was determined by the spike and recovery method. The results showed an average 104% recovery. The limit of detection and limit of quantification of the drug loading content were determined to be 0.3 and 1.0%, respectively. The method’s robustness is demonstrated by the notable similarities between the calibrations carried out using two different equipment setups at two different institutions.

show abstract

“…5,6 Several authors have reported on the stability of isoniazid [7][8][9][10] and its compatibility with drugs [11][12][13] and pharmaceutical excipients. 14 Given the above, the development of dosage forms containing isoniazid should be judicious.…”

Section: Introductionmentioning

confidence: 99%

Compatibility Study Between Isoniazid and Pharmaceutical Excipients Used in Solid Dosage Forms

Tibola¹,

Rodrigues²

2017

Int. Res. J. Pharm.

View full text Add to dashboard Cite

The compatibility between isoniazid (INH) and pharmaceutical excipients was studied using thermal analysis (DSC and TG/DTG) and vibrational spectroscopy (FTIR). Modifications in the peak shape, peak onset or peak maximum were verified using thermal analysis, especially DSC, in the physical mixtures. FTIR spectra showed good correlation between INH and most of excipients. Lactose and sodium metabisulfite were found to exhibit interactions with isoniazid.

show abstract

Infrared spectroscopy in pharmacy

Cited by 28 publications

References 33 publications

DFT outlook of solvent effect on function of nano bioorganic drugs

DFT outlook of solvent effect on function of nano bioorganic drugs

Direct Quantification of Drug Loading Content in Polymeric Nanoparticles by Infrared Spectroscopy

Compatibility Study Between Isoniazid and Pharmaceutical Excipients Used in Solid Dosage Forms

Contact Info

Product

Resources

About