Infrared Neural Stimulation of Thalamocortical Brain Slices

Cayce, Jonathan M.; Kao, Chris; Malphrus, Jonathan D.; Konrad, Peter E.; Mahadevan‐Jansen, Anita; Jansen, E.

doi:10.1109/jstqe.2009.2032424

Cited by 43 publications

(60 citation statements)

References 39 publications

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“…The possible reason relies on the different mechanisms, the current injection of electrical stimulation lead short term neural activation by activation of voltage-gated ion channels of neurons abruptly [1], but the optical stimulation needs to create a temporally and spatially mediated temperature gradient to activate the neurons [9]. The effects of pulse duration and stimulation intensity on neural response were explored in vestibular [18] and thalamocortical brain slices [17], the latency and amplitude of N1 varied with pulse duration and stimulation intensity may manifest the optical-induced inhibition [17].…”

Section: Resultsmentioning

confidence: 99%

“…Recently, optical stimulation has been introduced to stimulate CNS, and the excited and inhibited neural responses have been recorded in thalamocortical brain slices [17] and somatosensory cortex [16], respectively.…”

mentioning

confidence: 99%

“…In the reported experiments, infrared laser has been widely explored for the optical neural stimulation [6]- [11], [17], however, the feasibility of neural stimulation with visible light has never been attempted. This work is to test whether the optical stimulation with LED 620-nm red light can activate the cortical neural activity in vivo.…”

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confidence: 99%

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Optical stimulation of visual cortex with pulsed 620-nm red light

Hou

Mou

Shi

et al. 2011

2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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To explore the optical neural stimulation with visible light, 620-nm red light pulse emitted by LED was used to stimulate the left primary visual cortex of adult rat. The neural response in right primary visual cortex was recorded with a flexible microelectrode. By synchronized averaging the raw signal, optical evoked potentials (OEPs) were observed a negative wave and positive wave after optical stimuli. Furthermore, the amplitude and occurrence of the negative and positive wave were modulated by the strength and pulse width of the optical stimulus. The preliminary experiment suggested that, beyond the infrared laser, the pulse of visible light (e.g. red light) can modulate the neural activity in central nervous system.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Optical stimulation of visual cortex with pulsed 620-nm red light

Hou

Mou

Shi

et al. 2011

2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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“…They further showed that penetration depth of a few hundred microns was found to be ideal (close to the first two absorption peaks and in the valleys at longer wavelengths) and the energy thresholds were ∼0.3 J∕cm 2 , deposited in a pulse ranging from 0.25 to a few milliseconds. 8,11 [The selection of wavelengths has been limited by availability of light sources of sufficient power, but today some choices include the holmium-YAG laser (2.12 microns), thulium fiber lasers (tunable around 2 microns), and high-power semiconductor lasers (particularly 1450, 1465, and 1875 nm). The necessary continuous wave (CW) power ranges from a fraction of a watt to a few watts, depending on the wavelength and experimental setup.]…”

Section: Mechanism Of Ins Actionmentioning

confidence: 99%

Infrared neural stimulation: a new stimulation tool for central nervous system applications

Chernov

Roe

2014

Neurophoton

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Abstract. The traditional approach to modulating brain function (in both clinical and basic science applications) is to tap into the neural circuitry using electrical currents applied via implanted electrodes. However, it suffers from a number of problems, including the risk of tissue trauma, poor spatial specificity, and the inability to selectively stimulate neuronal subtypes. About a decade ago, optical alternatives to electrical stimulation started to emerge in order to address the shortcomings of electrical stimulation. We describe the use of one optical stimulation technique, infrared neural stimulation (INS), during which short (of the order of a millisecond) pulses of infrared light are delivered to the neural tissue. Very focal stimulation is achieved via a thermal mechanism and stimulation location can be quickly adjusted by redirecting the light. After describing some of the work done in the peripheral nervous system, we focus on the use of INS in the central nervous system to investigate functional connectivity in the visual and somatosensory areas, target specific functional domains, and influence behavior of an awake nonhuman primate. We conclude with a positive outlook for INS as a tool for safe and precise targeted brain stimulation.

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“…Furthermore, it has been demonstrated that NIS can successfully alter the electrophysiological characteristics in cultured cortical neurons and in thalamo-cortical brain slices. 8,9 Recently, Cayce et al 10 reported that pulsed infrared light with a wavelength of 1.876 μm and a pulse width of 250 μs, with a repetition rate of 50-200 Hz, can stimulate the somatosensory cortex of anesthetized rats and induce inhibitory responses. They found that the degree of neuronal modulation induced by NIS was dependent on the light stimulation energy.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared stimulation on globus pallidus and subthalamus

et al. 2013

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Abstract. Near-infrared stimulation (NIS) is an emerging technique used to evoke action potentials in nervous systems. Its efficacy of evoking action potentials has been demonstrated in different nerve tissues. However, few studies have been performed using NIS to stimulate the deep brain structures, such as globus pallidus (GP) and subthalamic nucleus (STN). Male Sprague-Dawley rats were randomly divided into GP stimulation group (n ¼ 11) and STN stimulation group (n ¼ 6). After introducing optrodes stereotaxically into the GP or STN, we stimulated neural tissue for 2 min with continuous near-infrared light of 808 nm while varying the radiant exposure from 40 to 10 mW. The effects were investigated with extracellular recordings and the temperature rises at the stimulation site were also measured. NIS was found to elicit excitatory responses in eight out of 11 cases (73%) and inhibitory responses in three cases in the GP stimulation group, whereas it predominantly evoked inhibitory responses in seven out of eight cases (87.5%) and an excitatory response in one case in STN stimulation group. Only radiation above 20 mW, accompanying temperature increases of more than 2°C, elicited a statistically significant neural response (p < 0.05). The responsiveness to NIS was linearly dependent on the power of radiation exposure. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Infrared Neural Stimulation of Thalamocortical Brain Slices

Cited by 43 publications

References 39 publications

Optical stimulation of visual cortex with pulsed 620-nm red light

Optical stimulation of visual cortex with pulsed 620-nm red light

Infrared neural stimulation: a new stimulation tool for central nervous system applications

Near-infrared stimulation on globus pallidus and subthalamus

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