Infrared nanoimaging of nanoscale sliding dislocation of collagen fibrils

Qiao, Zhi; Xue, Mengfei; Zhao, Yongqian; Huang, Yindong; Zhang, Ming; Chang, Chao; Chen, Jianing

doi:10.1007/s12274-021-3721-4

Cited by 14 publications

(2 citation statements)

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“…For biomedical applications, revealing chemical species can help to review hidden information previously unobservable through topography images. As an example, a recent study investigates the sliding dislocation of collagen fibrils, whose arrangement defects can play an important role in many common diseases such as bone fracture and fibrosis [ 91 ]. Using the scattering-type SNOM techniques as shown in Figure 6 , two distinct collagen fibril arrangements are reviewed, which helps to establish a deeper understanding of collagen-related diseases.…”

Section: Afm Molecular Species Characterizationmentioning

confidence: 99%

“… Scattering type SNOM image of collagen fibrils on a nerve section surface: ( a , b ) topography image of a section of the collagen fibrils, ( c ) third harmonic amplitude image at 1100 cm

Section: Figurementioning

confidence: 99%

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Review: Advanced Atomic Force Microscopy Modes for Biomedical Research

Xia

2022

Biosensors

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Visualization of biomedical samples in their native environments at the microscopic scale is crucial for studying fundamental principles and discovering biomedical systems with complex interaction. The study of dynamic biological processes requires a microscope system with multiple modalities, high spatial/temporal resolution, large imaging ranges, versatile imaging environments and ideally in-situ manipulation capabilities. Recent development of new Atomic Force Microscopy (AFM) capabilities has made it such a powerful tool for biological and biomedical research. This review introduces novel AFM functionalities including high-speed imaging for dynamic process visualization, mechanobiology with force spectroscopy, molecular species characterization, and AFM nano-manipulation. These capabilities enable many new possibilities for novel scientific research and allow scientists to observe and explore processes at the nanoscale like never before. Selected application examples from recent studies are provided to demonstrate the effectiveness of these AFM techniques.

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Section: Afm Molecular Species Characterizationmentioning

confidence: 99%

“… Scattering type SNOM image of collagen fibrils on a nerve section surface: ( a , b ) topography image of a section of the collagen fibrils, ( c ) third harmonic amplitude image at 1100 cm

Section: Figurementioning

confidence: 99%