1999
DOI: 10.1080/10426509908039585
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Infrared Microspectroscopic Imaging of Biomineralized Tissues using a Mercury-Cadmium-Telluride Focal-Plane Array Detector

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Cited by 26 publications
(5 citation statements)
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“…Specifically, age-and site-dependent changes in relative mineral content, as well as relative crystal maturity, are demonstrated in the whole incisors. FTIRI as an analytical imaging method has been used to obtain qualitative and quantitative information on both mineral and matrix of bone (Marcott et al, 1999;Mendelsohn et al, 1999;Boskey et al, 2002b), calcifying cartilage cultures (Boskey et al, 2002a), and cartilage (Bhargava and Levin, 2001;Camacho et al, 2001), with a spatial resolution of ~ 7 m. The two spectroscopic parameters, mineral:matrix ratio and crystallinity, were selected for dentin analysis because, as ratios, they are independent of sectioning artifacts, and they represent important properties. The mineral:matrix ratio is linearly related to the chemically measured ash weight (Pienkowski et al, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…Specifically, age-and site-dependent changes in relative mineral content, as well as relative crystal maturity, are demonstrated in the whole incisors. FTIRI as an analytical imaging method has been used to obtain qualitative and quantitative information on both mineral and matrix of bone (Marcott et al, 1999;Mendelsohn et al, 1999;Boskey et al, 2002b), calcifying cartilage cultures (Boskey et al, 2002a), and cartilage (Bhargava and Levin, 2001;Camacho et al, 2001), with a spatial resolution of ~ 7 m. The two spectroscopic parameters, mineral:matrix ratio and crystallinity, were selected for dentin analysis because, as ratios, they are independent of sectioning artifacts, and they represent important properties. The mineral:matrix ratio is linearly related to the chemically measured ash weight (Pienkowski et al, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…Water vapor and PMMA spectral interferences were corrected for as published elsewhere. (18) Parameters calculated were (1) mineral crystal maturity/crystallinity, expressed as absorbance ratio at two specific wavelengths (1030 and 1020 cm −1 ) (18) ; and (2) relative ratio of pyridinium and deH-DHLNL collagen cross-links, also expressed as the absorbance ratio at two specific wavelengths (1660 and 1690 cm −1 ). (20) For each section analyzed, absorbance ratios were expressed as color-coded images (using the same scale for all data; Origin 6.0, Microcal Software, Northampton, MA, USA) to depict spatial distribution of outcomes.…”
Section: Ftiri Data Acquisition and Spectral Image Analysismentioning
confidence: 99%
“…Analysis focused on trabecular bone to determine the effect of treatment on mineral maturity/crystallinity and collagen cross-links as a function of trabecular surface metabolic activity or tissue age (forming versus resorbing surfaces). FTIRI is a validated spectroscopic technique that allows the determination of mineral maturity/crystallinity (apatite stoichiometry, ionic lattice substitutions, mineral crystallite size), and the ratio of pyridinium (nonreducible) to dehydro-dihydroxylysinonorleucine (deDHLNL; reducible) collagen cross-links in mineralized sections of bone at the microscopic level, with a spatial resolution of ∼6.3 m. (18)(19)(20) It has been previously used to study differences between normal and osteoporotic bone. (21)(22)(23)(24)(25) It has been also used to examine effects of other antiresorptive (ibandronate, cyclic hormonal replacement [HRT]) and anabolic (PTH) agents on bone material properties in trabeculae devoid of resorbing surfaces.…”
Section: Introductionmentioning
confidence: 99%
“…(53) More recently, Fourier transform infrared microspectroscopy (FTIRM) and infrared imaging (FTIRI) have demonstrated variations in both mineral content and mineral crystal size, with the most mature mineral having the largest, more perfect crystals. (54)(55)(56)(57) Since mineral content contributes to the material component of bone's biomechanical performance, (2) it is likely that crystal properties also make a contribution. FTIRM and FTIRI also reveal differences in collagen maturity throughout normal trabeculae that are not detected in osteoporotic trabeculae.…”
Section: Bone Ultrastructure and Bone Strengthmentioning
confidence: 99%