Infrared Determination of Iodochlorhydroxyquin in Pharmaceutical Preparations: Analysis of Creams, Inserts, Lotions, and Ointments

High-Performance Liquid Chromatographic Analysis of Iodochlorohydroxyquin and Hydrocortisone in Ointments and Creams

“…As can be seen in Fig. 1, the peaks for I, 11, and internal standard are well separated. Optimum extraction of I was obtained with the mobile phase (pH 2.8).…”

“…These results were compared with the same ratios for the standard I, 11, and internal standard. No differences were found when comparing the respective ratios, indicating that constituents in the bases that may have been extracted did not interfere with the analyses of the desired compounds.…”

Determination of Iodochlorhydroxyquin and Corticosteroids in Pharmaceutical Formulations

“…tions Sulfacetamide sodium solutions have been shown titration method used for sulfacetamide sodium ophthalmic solution in USP XVIII (6) does not distinguish between sulfacetamide and sulfanilamide to undergo hydrolysis to sulfanilamide and sodium acetate and oxidative discoloration (1)(2)(3)(4)(5). It affords an average recovery of 100.9% of added sodium liquid chromatography-assay of sulfacetamide ophthalmic solusulfacetamide with a relative standard deviation of 1.9%.…”

“…IR methods specific for I in pharmaceutical products were described (4,5 ) , but these procedures are difficult to use due to the volatility and odor of the carbon disulfide and the small volumes required in the extraction step. NF XI11 (3) requires the same IR technique to deter-mine I in creams, lotions, and ointments containing I plus hydrocortisone and uses the blue tetrazolium method for the corticosteroid.…”