Infrared and Raman Spectroscopic Studies of Molecular Disorders in Skin Cancer

Study of the Development of Carotid Artery Atherosclerosis upon Oxidative Stress using Infrared Spectroscopy and Scanning Electron Microscopy

“…In spectra b and c (see Figure 1), the intensities of absorption bands for v as CH 2 and v s CH 2 in the spectra of the patients were quite prominent, while the intensities for the bands of v as CH 3 and v s CH 3 decreased considerably. This suggested that the lipophilic environment had a higher conformational order and rigidity [18][19][20][21][22][23][24]. The high-intensity band seen at 1,734 cm -1 was assigned to the aldehyde group vCHO resulting from lipid and protein peroxidation.…”

“…The FT-IR spectra provide a wealth of information not only about the changes that take place inside the molecular structures but also about the changes happening in the environment of biomolecules within the cell. The FT-IR spectra are very characteristic of the molecules and structures in the specimen, in addition to the "fingerprint region" that marks the characteristic changes induced to these biological molecules during disease progression [21][22][23][24]. Based on midinfrared spectra in the region spanning 4,000-400 cm -1 and results from the literature on normal and malignant tissues, it is clear that the FT-IR spectra can be used for clinical trials and in the diagnosis of cancer and other diseases [25,26].…”

“…In the present study, we used FT-IR spectroscopy [18][19][20][21][22][23][24][25][26][27][28][29] in combination with scanning electron microscopy (SEM) [1,21,28] to study the mechanism of carotid artery mineralization and atheromatic plaque formation.…”

Discrimination of melanoma cell lines with Fourier Transform Infrared (FTIR) spectroscopy

“…Furthermore, the amide II band shifted to a lower wavenumber in metastatic cells. This is likely a result of conformational alterations occurring in the secondary structures of proteins [23].…”

The role of oxidative stress on molybdenum enzymes and ischemic reperfusion injury in hyperuricaemic patients. An infrared spectroscopic study

“…The individual spectral bands are the "fingerprint" not only of the chemical components of the tissues, such as proteins, phospholipids, DNA, but also of the disease [10][11][12][13][14][15][16][17]. By using FT-IR spectroscopy it is easy to elucidate structural features of proteins' secondary structure, such as protein folding, which could be used as "marker bands" for the diagnosis and the progression of the diseases [10][11][12][13][14][15][16]. Although a biological sample is complex, there are only a few main features that dominate the infrared spectrum, and it is essential to understand the origin of such absorption bands of the functional groups.…”