Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours

Yu, Huapeng; Chen, Liping; Lei, Huiyang; Pi, Guilin; Xiong, Rui; Jiang, Tao; Wu, Dongqin; Sun, Fengrui; Gao, Yang; Li, Yuanhao; Peng, Weiming; Huang, Bingyu; Song, Guangsen; Wang, Xin; Lv, Jingru; Jin, Zetao; Ke, Dan; Yang, Ying; Wang, Jian-Zhi

doi:10.1038/s41467-022-33139-6

Cited by 19 publications

(12 citation statements)

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“…Our data showed that activation of the DP/DTT increased anxiety-like behavior in the OFT and EPM. A considerable body of work implicates the rodent mPFC in the regulation of anxiety-like behavior [7,13,[22][23][24][25][26][27][28][29]86,[14][15][16][17][18][19][20][21], with contradictory findings supporting anxiogenic [18][19][20][21][22][23][53][54][55] or anxiolytic [24][25][26][27] roles. Manipulations selective to the vmPFC/IL also see conflicting effects on EPM and open field performance [21,24,26,60].…”

Section: Discussionmentioning

confidence: 99%

“…The medial prefrontal cortex (mPFC) is a key brain region involved in high-order functions such as attention [1,2], decision making [3,4], working memory [5,6], social behavior [7][8][9][10], mood [11,12] and anxiety [7,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. The mPFC integrates inputs from cortical sensory and motor systems, as well as subcortical brain structures [31][32][33][34][35][36] toward top-down control of output structures such as the amygdala, thalamus, hypothalamus and bed nucleus of the stria terminalis (BNST) [31,34,[36][37][38].…”

Section: Introductionmentioning

confidence: 99%

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Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice

Botterill

Khlaifia

Appings

et al. 2023

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The medial prefrontal cortex (mPFC) is critically involved in cognitive and emotional function and underlies many neuropsychiatric disorders, including mood, fear and anxiety disorders. In rodents, disruption of mPFC activity affects anxiety- and depression-like behavior, with evidence supporting specialized contributions from its subdivisions. The rodent mPFC is often subdivided into the anterior cingular cortex (ACC), prelimbic cortex (PL), and the infralimbic cortex (IL), and broken down into the dorsomedial prefrontal cortex (dmPFC), spanning ACC and dorsal PL, and the ventromedial prefrontal cortex (vmPFC), which includes the ventral PL, IL, and in some studies the dorsal peduncular cortex (DP) and dorsal tenia tecta (DTT). The DP/DTT have recently been implicated in the regulation of stress-induced sympathetic responses via projections to the hypothalamus. While many studies implicate the PL and IL in anxiety-, depression-like and fear behavior, the contribution of the DP/DTT to affective and emotional behavior remains unknown. Here, we used chemogenetics to bidirectionally modulate DP/DTT activity and examine its effects on affective behaviors, cognition and stress responses in naive male and female C57BL/6J mice. We found that acute chemogenetic activation of DP/DTT neurons caused a significant increase in anxiety-like behavior in the open field and elevated plus maze tests, as well as in passive coping in the tail suspension test. In contrast, chemogenetic inhibition of the DP/DTT had no effect on affective behavior, but facilitated auditory fear memory acquisition without affecting memory retrieval. Additionally, DP/DTT activation led to an increase in plasma corticosterone levels. These findings point to the DP/DTT as a new regulator of affective behavior in mice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice

Botterill

Khlaifia

Appings

et al. 2023

Preprint

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“…In addition, the mPFC has been shown to suppress depression-induced amygdala-mediated hyperactive affective responses by recruiting BLA inhibitory interneurons (Rosenkranz and Grace, 2001 ; Bertholomey et al, 2022 ). Evidence has shown that the activation of Ventromedial prefrontal cortex (vmPFC)–pBLA inputs diminishes chronic unpredictable mild stress- (CUMS-) induced depression- and anxiety-like behaviors via activation of the pBLA Calb1 neuron (Yu et al, 2022 ). These results suggest that mPFC–BLA innervation regulates affective disorders in a BLA inhibition-dependent manner and that depression-like behavior may be associated with a circuit.…”

Section: Introductionmentioning

confidence: 99%

Decreased phase information transfer from the mPFC to the BLA: During exploratory behavior in CUMS rats

et al. 2023

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IntroductionDepression is a mental disorder characterized by aberrant exploratory behavior. Environmental factors, such as chronic stress, are commonly used to induce depression-like behavior in rodent models. The medial prefrontal cortex (mPFC) and the basolateral amygdala (BLA) are crucial sites in subjects with chronic stress-induced depression. The transmission of amplitude information from the mPFC to the BLA was abated during exploratory behavior in depressive rats; however, the nature of the phase interaction between these two sites remains unknown.MethodsWe used chronic unpredictable mild stress (CUMS) to model depression in rats and acquired local field potentials (LFPs) via multiple electrodes implanted in the mPFC and the BLA while rats (both the control and CUMS groups, respectively) were allowed to explore freely in an open field. The weighted phase lag index (WPLI) within the mPFC and the BLA and phase transfer entropy (PTE) from the mPFC to BLA were computed for two groups of rats (control and CUMS rats) to quantify the phase information transmission.ResultsRats subjected to CUMS showed a decrease in exploratory behavior. The WPLI within the mPFC and the BLA showed strikingly higher phase synchrony at theta frequencies (4–12 Hz) than other frequency bands during exploratory behavior in both the control and CUMS groups. The results of theta PTE from the mPFC to BLA showed that PTE was significantly decreased in the CUMS group compared with the control group.DiscussionsThese findings demonstrated that attenuated phase information transfer might restrain exploratory behavior in CUMS rats.

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“…The COVID-19 pandemic resulted in a significant increase in depression and anxiety cases within a year 2 . Chronic stress is the principal environmental factor that triggers a decline in mood, leading to depression and anxiety 3 .…”

Section: Introductionmentioning

confidence: 99%

Levy statistics define anxiety and depression in mice subjected to chronic stress

Li¹,

Nie

Zhang³

et al. 2023

Preprint

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Anxiety and depression are considered coping mechanisms organisms adopt in response to external stressors. We employed Levy statistics to investigate the movement patterns of rodent models subjected to stress and compared them to non-stressed controls. Our analysis revealed that stressed mice exhibited heavy-tailed distributions in open fields, consistent with the Levy flights utilized by animal predators in search of scarce food sources. In contrast, non-stressed mice demonstrated a normal distribution of speed. We used the two-dimensional Kolmogorov-Smirnov test to identify significant differences in the γ and μ parameters derived from Levy flight between anxiety, depression, and control mice. Additionally, we employed the support vector machine algorithm to determine the optimal separation of each group. Furthermore, our mathematical model demonstrated the therapeutic effects of fluoxetine. These findings have the potential to contribute to the development of more precise definitions of anxiety and depression, as well as facilitate the evaluation of pharmaceutical developments.

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Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours

Cited by 19 publications

References 71 publications

Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice

Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice

Decreased phase information transfer from the mPFC to the BLA: During exploratory behavior in CUMS rats

Levy statistics define anxiety and depression in mice subjected to chronic stress

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