Influenzal Pneumonia : The Intravenous Injection of Hydrogen Peroxide.

Oliver, T. H.; Murphy, D.M.

doi:10.1016/s0140-6736(01)11118-9

Cited by 29 publications

(19 citation statements)

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“…In 1920, Oliver and Murphy (27) gave H202 by vein to patients who appeared to be dying of pneumonia in an attempt to generate oxygen through the catalatic decomposition of H202 in the bloodstream. The dramatic recovery of some of their patients encouraged other investigators to use parenteral H202 to increase the oxygen tension in tumors during radiotherapy (29,32,(38)(39)(40)(41) or chemotherapy (34,35,37,38).…”

Section: Discussionmentioning

confidence: 99%

Antitumor effects of hydrogen peroxide in vivo

Nathan¹,

Cohn²

1981

The Journal of Experimental Medicine

122

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Glucose oxidase, covalently coupled to polystyrene microspheres (GOL), produced H(2)0(2) at an average rate of 3.6 nmol/min per 10(9) beads under standard assay conditions. Injection of 1.3 × 10(10) to 1.1 × 10(11) GOL i.p. prolonged the survival of mice by 27 percent after injection of 10(6) P388 lymphoma cells in the same site, consistent with destruction of 97.6 percent of the tumor cells. Placing mice for several hours in 100 percent O(2), the probable rate-limiting substrate for GOL, afforded a 42 percent prolongation of survival from P388 lymphoma, consistent with destruction of 99.6 percent of the tumor cells. When the P388 inoculum was 10(5), 10(4), or 10(3) cells, GOL led to long-term survival (presumed cure) of 23 percent, 77 percent, and 92 percent of the mice, respectively, consistent with reduction of the injected tumor dose to less than 10 cells. Subcutaneous growth of 10(5) P388 cells (approximately 300 lethal dose to 50 percent of mice) was suppressed in 83 percent of mice by admixture of GOL with the tumor cell inoculum. GOL alone had no effect against a more peroxide-resistant tumor, P815 mastocytoma. However, P815 cell glutathione reductase could be inhibited in vivo by well-tolerated doses of the antitumor agent, 1,3-bis(2-chloroethyl)- 1-nitrosourea (BCNU). BCNU alone cured few mice with P815. Together, BCNU and GOL apparently cured 86 percent of mice injected with 10(6) P815 cells i.p. The protective effect of GOL was abolished by boiling it to inactivate the enzyme, by co-injection of catalase coupled to latex beads, or by delaying the injection of tumor cells for 3 h, by which time the beads had formed aggregates. Soluble glucose oxidase, in doses threefold higher than that bound to GOL, had no detectable antitumor effect. A single injection of preformed H(2)0(2) readily killed P388 cells in the peritoneal cavity, but only at doses nearly lethal to the mice. In contrast, GOL had very little toxicity, as judged by the normal appearance of the mice for over 400 d, gross and microscopic findings at autopsy, and various blood tests. GOL injected i.p. remained in the peritoneal cavity, where it was gradually organized into granulomata by macrophages, without generalized inflammation. Thus, an H(2)0(2)-generating system confined to the tumor bed exerted clear- cut antitumor effects with little toxicity to the host.

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Section: Discussionmentioning

confidence: 99%

Antitumor effects of hydrogen peroxide in vivo

Nathan¹,

Cohn²

1981

The Journal of Experimental Medicine

122

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“…In 1888, the first medical use of H 2 O 2 was described by Love as efficacious in treating numerous diseases, including scarlet fever, diphtheria, nasal catarrh, acute coryza, whooping cough, asthma hay fever and tonsillitis (Love, 1888). Similarly, Oliver and collaborators reported that intravenous injection of H 2 O 2 was efficacious in treating influenza pneumonia in the epidemic following World War I (Oliver et al ., 1920). Despite its beneficial effects, in the 1940s medical interest in further research on H 2 O 2 was slowed down by the emerging development of new prescription medicines.…”

Section: Historical Notesmentioning

confidence: 95%

Therapeutic potential of targeting hydrogen peroxide metabolism in the treatment of brain ischaemia

Armogida

Nisticò

Mercuri

2012

British J Pharmacology

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For many years after its discovery, hydrogen peroxide (H2O2) was viewed as a toxic molecule to human tissues; however, in light of recent findings, it is being recognized as an ubiquitous endogenous molecule of life as its biological role has been better elucidated. Indeed, increasing evidence suggests that H2O2 may act as a second messenger with a pro-survival role in several physiological processes. In addition, our group has recently demonstrated neuroprotective effects of H2O2 on in vitro and in vivo ischaemic models through a catalase (CAT) enzyme-mediated mechanism. Therefore, the present review summarizes experimental data supporting a neuroprotective potential of H2O2 in ischaemic stroke that has been principally achieved by means of pharmacological and genetic strategies that modify either the activity or the expression of the superoxide dismutase (SOD), glutathione peroxidase (GPx) and CAT enzymes, which are key regulators of H2O2 metabolism. It also critically discusses a translational impact concerning the role played by H2O2 in ischaemic stroke. Based on these data, we hope that further research will be done in order to better understand the mechanisms underlying H2O2 functions and to promote successful H2O2 signalling based therapy in ischaemic stroke. Abbreviations3-AT, 3-amino-1,2,4-triazole; ACSF, artificial cerebral spinal fluid; BSO, buthionine sulfoximine; CAT, catalase; DA, dopamine; DHE, dihydroethidium; fEPSP, field excitatory postsynaptic potential; GPx, glutathione peroxidase; HIF, hypoxia-inducible factor; IPC, ischaemic preconditioning; IR, ischaemia-reperfusion; KATP, ATP-sensitive K + channel; MCAo, middle cerebral artery occlusion; MCS, mercaptosuccinate; mTOR, mammalian target of rapamycin; NF, nuclear factor; NOS, nitric oxide synthase; O2, molecular oxygen; · O2 -, superoxide anion; OGD, oxygen/glucose-deprivation; •OH, hydroxyl radical; PGC1a, PPARg coactivator1a; PI3K, phosphatidylinositol 3-kinase; PPARg, peroxisome proliferator-activated receptorg; Prx, peroxiredoxin; ROS, reactive oxygen species; SNc, substantia nigra pars compacta; SOD, superoxide dismutase; TDP, thiolate-dependent phosphatase; Tg(CAT), transgenic mouse over-expressing catalase; TRP, transient receptor potential; WT, wild-type NomenclatureThe drug/molecular target nomenclature used in this review conforms to the British Journal of Pharmacology's Guide to Receptors and Channels (Alexander et al., 2011), where applicable. Historical notesThe history of H2O2 began in 1818 when it was discovered by Thénard who named it eau oxygénée (Thénard, 1818). Since the mid-1800s, H2O2 has been marketed for a wide variety of uses, including non-polluting bleaching, oxidizing agent, BJP British Journal of Pharmacology DOI:10.1111DOI:10. /j.1476DOI:10. -5381.2012 (Wolffenstein, 1894). In 1888, the first medical use of H2O2 was described by Love as efficacious in treating numerous diseases, including scarlet fever, diphtheria, nasal catarrh, acute coryza, whooping cough, asthma hay fever and tonsillitis (Love, 1888). Similar...

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“…This quickly forms O2 molecules and this could supply O2 to correct hypoxemia. This was re ported in 1920 by Oliver et al [1] in cases of critically ill patients with influenza pneumonia, and decreased mortality was the result. This mode of therapy was not, however, reported subsequently.…”

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confidence: 85%

Effect of Urea-Hydrogen Peroxide on Hypoxia in Rabbits

Wu¹

1985

Respiration

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PaO₂ in hypoxemic rabbits was raised 30 min after intravenous administration of urea-hydrogen peroxide (U-H₂O₂). Peak levels appeared 2 h after administration of the drug and the effect continued up to 4 h. The treatment was effective and no side effects in the rabbits were observed.A new technique is described to produce hypoxemia in rabbits using a special mask. In contrast to previously described techniques the rabbits in this study could be kept alive with a stable hypoxemia for at least 4–5 h. This model may be useful for future studies requiring similar hypoxemic conditions in experimental animals.

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Influenzal Pneumonia : The Intravenous Injection of Hydrogen Peroxide.

Cited by 29 publications

References 0 publications

Antitumor effects of hydrogen peroxide in vivo

Antitumor effects of hydrogen peroxide in vivo

Therapeutic potential of targeting hydrogen peroxide metabolism in the treatment of brain ischaemia

Effect of Urea-Hydrogen Peroxide on Hypoxia in Rabbits

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