PaO2 in hypoxemic rabbits was raised 30 min after intravenous administration of urea-hydrogen peroxide (U-H2O2). Peak levels appeared 2 h after administration of the drug and the effect continued up to 4 h. The treatment was effective and no side effects in the rabbits were observed.A new technique is described to produce hypoxemia in rabbits using a special mask. In contrast to previously described techniques the rabbits in this study could be kept alive with a stable hypoxemia for at least 4–5 h. This model may be useful for future studies requiring similar hypoxemic conditions in experimental animals.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.