Influenza vaccination acceptance among health-care workers: A nationwide survey

Maltezou, Helen C.; Maragos, Antonios; Katerelos, Panos; Paisi, Antigoni; Karageorgou, K; Papadimitriou, T; Pierroutsakos, Ioannis N.

doi:10.1016/j.vaccine.2008.01.049

Cited by 78 publications

(48 citation statements)

References 15 publications

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“…Although seasonal vaccination programmes are in place principally to afford protection to patients [1,2], the primary justification of health care workers for receiving seasonal vaccine is often selfish and to protect themselves, rather than their patients [8, 10,11,14]. Consistent with this observation is our finding that acceptance of pre-pandemic vaccine is strongly associated with the belief that seasonal vaccine provides protection to the individual.…”

Section: Discussionsupporting

confidence: 72%

“…Many individuals would not accept prepandemic vaccine as they are unconcerned about the risk of pandemic influenza; this is consistent with observations that the belief of seasonal influenza as a mild infection is associated with non-uptake of seasonal vaccine [8,14,23]. Despite studies showing that influenza vaccines are well-tolerated, concerns over adverse effects remain a substantial barrier to pre-pandemic and seasonal influenza vaccination [8,10,11,20].…”

Section: Discussionsupporting

confidence: 60%

“…Once a healthcare worker has been vaccinated against seasonal influenza, this is a strong predictor of seasonal vaccine uptake in subsequent years [8][9][10][11][18][19][20][21]. This study shows that the receipt of previous seasonal vaccine is also strongly associated with a willingness to accept pre-pandemic vaccine.…”

Section: Discussionmentioning

confidence: 92%

“…As healthcare workers are recognised to be both introducers and reservoirs of influenza virus in the hospital setting, their vaccination is an important strategy to reduce the frequency and mortality of nosocomial outbreaks [2][3][4]. Although vaccination of healthcare workers also reduces rates of influenza-related illness and absenteeism among recipients [5,6], seasonal vaccine uptake among healthcare workers in the UK [3,7,8] and elsewhere [7,[9][10][11][12][13] is often low. Barriers to increasing coverage of seasonal influenza vaccination include inconvenience to obtain vaccine, belief that influenza is a mild illness, and concerns over vaccine efficacy or adverse reactions [1,8,9,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Willingness of healthcare workers to accept voluntary stockpiled H5N1 vaccine in advance of pandemic activity

Pareek

Clark

Dillon

et al. 2009

Vaccine

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Frontline healthcare workers will be at increased risk of infection during the next influenza pandemic. Proactive priming with pre-pandemic vaccine may protect staff and reduce nosocomial transmission. Despite campaigns to increase seasonal influenza vaccine coverage, uptake rates among healthcare workers are generally low, so it is uncertain whether they would participate in voluntary pre-pandemic vaccine programmes. We conducted a cross-sectional questionnaire survey of healthcare workers in a large UK teaching hospital during, and six months after, a period of intense media reporting of an H5N1 outbreak at a commercial UK poultry farm. A total of 520 questionnaires were returned, representing 20% of the frontline workforce. More respondents were willing to accept pre-pandemic vaccine during the period of heightened media attention than after (166/262, 63.4% versus 134/258, 51.9%; p=0.009). Following multivariate analysis, factors associated with willingness to accept pre-pandemic vaccine were: receipt of previous seasonal influenza vaccine (odds ratio 5.1, p<0.0001), belief that seasonal vaccine benefits themselves (OR 1.9, p=0.003), pandemic risk is high (OR 35.6, p=0.001) and that healthcare workers are threatened by a pandemic (OR 2.6, p<0.0001). Those who would not accept prepandemic vaccine (220 of 520 respondents, 42.7%) do not perceive pandemic influenza as a serious threat, and have concerns regarding vaccine safety. A majority of healthcare workers are amenable to accepting pre-pandemic vaccination if offered.Improving coverage of seasonal vaccine would increase pre-pandemic vaccine uptake if a proactive priming strategy was implemented.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Willingness of healthcare workers to accept voluntary stockpiled H5N1 vaccine in advance of pandemic activity

Pareek

Clark

Dillon

et al. 2009

Vaccine

View full text Add to dashboard Cite

show abstract

“…In the case of the smallpox vaccine, cytokines are linked not only with vaccine efficacy but also with adverse events 6. A frequently cited rationale for avoiding annual influenza vaccines is concern about experiencing side effects 7, 8, 9, 10, 11. Public concerns about vaccine side effects can undermine immunization programs, including national or statewide seasonal influenza vaccine campaigns 12, 13.…”

Section: Introductionmentioning

confidence: 99%

Rapid changes in serum cytokines and chemokines in response to inactivated influenza vaccination

Talaat

Halsey

Cox

et al. 2018

Influenza Resp Viruses

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BackgroundThe timing of host cytokine responses to influenza vaccination is poorly understood.ObjectivesWe examined serum cytokine kinetics following inactivated trivalent influenza vaccine (TIV) to better understand potential relationships between markers of inflammation and TIV‐related side effects.Patients/MethodsTwenty healthy adult subjects received TIV. Cytokines/chemokines were assessed in intervals from 3 hours to 14 days. Antibody titers were measured at baseline and Day 14.ResultsSerum cytokine responses to TIV were evident as early as 3 hours post‐immunization. Compared to baseline, IFN‐γ and IP‐10 were significantly elevated 7 hours after TIV administration. Both remained elevated and peaked between 16 and 24 hours before returning to baseline by 44 hours post‐vaccination. Although IL‐8 levels were variable between subjects during the first 24 hours after TIV, by 44 hours, IL‐8 was significantly lower compared to baseline. Interestingly, IL‐8 levels remained significantly lower for up to 2 weeks after receiving TIV. Fifteen of 20 subjects reported mild adverse events. The one subject who reported moderate myalgias and injection site pain after vaccination displayed a distinctive, early cytokine response profile which included IL‐6, IL‐2, IL‐8, IP‐10, MCP‐1, TNF‐α, TARC, and MCP‐4.ConclusionsSerum cytokines changed rapidly following TIV and generally peaked at 24 hours. Trivalent influenza vaccine‐induced reductions in IL‐8 occurred later (44 hours) and were sustained for 2 weeks. An outlier response coincided with the only moderate side effects to the vaccine. These data suggest that early cytokine/chemokine responses may provide additional insight into the pathogenesis of adverse events and immune reactivity to vaccination.

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Vaccination Coverage Against Seasonal Influenza of Workers in the Primary Health Care Units in the Prefecture of Chania

Maragkaki¹,

Matalliotakis²

2021

Applied Modeling Techniques and Data Analysis 2

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Influenza vaccination acceptance among health-care workers: A nationwide survey

Cited by 78 publications

References 15 publications

Willingness of healthcare workers to accept voluntary stockpiled H5N1 vaccine in advance of pandemic activity

Willingness of healthcare workers to accept voluntary stockpiled H5N1 vaccine in advance of pandemic activity

Rapid changes in serum cytokines and chemokines in response to inactivated influenza vaccination

Vaccination Coverage Against Seasonal Influenza of Workers in the Primary Health Care Units in the Prefecture of Chania

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