Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy

COVID-19 Vaccines and the Virus: Impact on Drug Metabolism and Pharmacokinetics

“…They are also commonly associated with other vaccines and are caused by the production and release of cytokines into the circulation (2011; Herve et al, 2019). While several reports have described interactions between drugs with narrow therapeutic windows and influenza vaccines (Raaska et al, 2001;Robertson, 2002;Carroll and Carroll, 2009), these results have not been able to be fully replicated in controlled clinical trials (Stults and Hashisaki, 1983;Gomolin et al, 1985;Soontornpun et al, 2020) which suggests that patient specific characteristics such as altered drug clearance prior to immunization may also be required for notable observation of changes in CYP soon after immunization (Meredith et al, 1985). To date, the impact of boosting doses of a vaccine has not been investigated in the clinic nor in animal models of drug metabolism.…”